Objective:To assess Nanjing inhabitants’ knowledge,attitudes,and practice (KAP) with respect to epilepsy in Nanjing. At the same time advertised and popularized the knowledge about epilepsy to inhabitants. Methods:The door to door survey was used to interview inhabitants who give an informed consent and nor ever had an epilepsy seizure with knowledge,attitudes,and practice (KAP) questionnaire by stratified cluster sampling. Results:A total of 3 147 participants completed the questionnaire,there were 99.5% of participants had heard about epilepsy,among whom,31.9% knew at least one patient with epilepsy,and 41.7% had seen at least one epileptic seizure. 58.2% of participants thought epilepsy is an untreatable condition,5.0% of the respondents thought that epilepsy was contagious,17.2% thought it was a form of insanity. With respect to attitudes,12.3% and 84.1% would object their children to associate or marry with epilepsy patients. The independent determinants of attitudes were the belief that epilepsy is a form of insanity or contagious or is untreatable,and being married. Conclusion:The level of understanding and related knowledge of epilepsy affects attitudes to the patients with epilepsy,health education intervention about epilepsy should be carried out actively in this population,though Nanjing residents have a high awareness of epilepsy.