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?Effect and mechanism of homocysteine on Parkinson’s disease induced by 6-OHDA
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    Abstract:

    Objective: To study the effects and mechanism of homocysteine(Hcy) on Parkinson’s disease(PD) induced by 6-hydroxydopamine(6-OHDA) in vivo. Methods:Forty rats were divided into 4 groups. 6-OHDA or the solvent of 6-OHDA was focally administrated to induce PD, 2 h later Hcy or 0.9% sodium chloride was administrated in the ipsolateral substantial nigra(SN). We used behavioral testing, Immolunohistochemical techniques, biochemistry techniques to detect the injury of SN. Results:The rotary turns of PD rats induced by 6-OHDA showed significant increase after treatment with Hcy compared with the controls(P < 0.05). Also the numbers of tyrosine hydroxylase(TH)-stained neurons were decreased, and dendrites were fragmented and truncated. Free radicals were increased and antioxidant enzymes decreased. Conclusion:Focal infusion of Hcy into the SN increased the vulnerability of the dopaminergic neurons to 6-OHDA-induced degeneration, it seems that the endangering effect of Hcy is due to exacerbating oxidative stress.

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Hongxia Xing, Hai Peng, Xuebing Cao, Shenggang Sun.[J].南京医科大学学报(自然科学版),2008,28(1):12-17

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  • 收稿日期:2007-09-10
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