Page 141 - 南京医科大学学报自然科学版
P. 141
第41卷第12期 曹 杨,舒 磊,冯旰珠. 呼吸道及肠道菌群在慢性阻塞性肺病发病机制中的研究进展[J].
2021年12月 南京医科大学学报(自然科学版),2021,41(12):1843-1849 ·1847 ·
2(nucleotide binding oligo domain protein 2,NOD2)等 (4):634-650
模式识别受体(pattern recognition receptoers,PRR), [7] KAHN F W,JONES J M. Diagnosing bacterial respiratory
TLR在固有免疫中起着至关重要的作用。业已证实 infection by bronchoalveolar lavage[J]. J Infect Dis,
益生菌含有 TLR 配体,参与固有免疫系统的激活, 1987,155(5):862-869
[8] GARCIA⁃CLEMENTE M,DE LA ROSA D,MAIZ L,et
补充益生菌可增强机体固有免疫能力,从而对呼吸
al. Impact of pseudomonas aeruginosa infection on pa⁃
道感染发挥抑制效应 [61,66-68] 。
tients with chronic inflammatory airway diseases[J]. J
6 总 结 Clin Med,2020,9(12):3800
[9] BUDDEN K F,GELLATLY S L,WOOD D L,et al. Emerg⁃
综上所述,COPD 患者呼吸道及肠道菌群多样 ing pathogenic links between microbiota and the gut⁃lung
性下降,有益菌群减少,致病性变形菌门增多;香烟 axis[J]. Nat Rev Microbiol,2017,15(1):55-63
烟雾暴露影响了肺部免疫,降低呼吸道、肠道菌群 [10] GILL S R,POP M,DEBOY R T,et al. Metagenomic anal⁃
多样性及有益菌群丰度,抑制SCFA的产生;减少香 ysis of the human distal gut microbiome[J]. Science,
烟烟雾暴露可减少 COPD 发病,改善预后。高膳食 2006,312(5778):1355-1359
[11] TURNBAUGH P J,LEY R E,HAMADY M,et al. The hu⁃
纤维饮食及肠道益生菌制剂(如乳杆菌、双歧杆菌)
man microbiome project[J]. Nature,2007,449(7164):
有利于促进宿主免疫反应提高,在抑制呼吸道感
804-810
染、减轻 COPD 炎症方面发挥积极效应。随着分子
[12] DICKSON R P,ERB⁃DOWNWARD J R,FREEMAN C
检测技术的不断成熟和生物信息学手段的日臻完 M,et al. Bacterial topography of the healthy human lower
善,有关 COPD 菌群特征的相关研究将会越来越深 respiratory tract[J]. mBio,2017,8(1):e02287-16
入。减少 COPD 患者下呼吸道“关键物种”病原菌、 [13] BADOR J,NICOLAS B,CHAPUIS A,et al. 16S rRNA
增加膳食纤维及肠道益生菌的摄入有利于改善呼 PCR on clinical specimens:impact on diagnosis and ther⁃
吸系统免疫功能,这已成为一个新兴的临床研究视 apeutic management[J]. Med Mal Infect,2020,50(1):
角,必将为COPD的治疗带来新的思路。 63-73
[14] MENDEZ R,BANERJEE S,BHATTACHARYA S K,et
[参考文献]
al. Lung inflammation and disease:a perspective on mi⁃
[1] DEVADOSS D,LONG C,LANGLEY R J,et al. Long non⁃ crobial homeostasis and metabolism[J]. IUBMB Life,
coding transcriptome in chronic obstructive pulmonary 2019,71(2):152-165
disease[J]. Am J Respir Cell Mol Biol,2019,61(6): [15] LEE S W,KUAN C S,WU L S,et al. Metagenome and
678-688 metatranscriptome profiling of moderate and severe
[2] EHTESHAMI⁃AFSHAR S,FITZGERALD J M,DOYLE⁃ COPD sputum in taiwanese han males[J]. PLoS One,
WATERS M M,et al. The global economic burden of asth⁃ 2016,11(7):e159066
ma and chronic obstructive pulmonary disease[J]. Int J [16] ALLALI I,ARNOLD J W,ROACH J,et al. A comparison
Tuberc Lung Dis,2016,20(1):11-23 of sequencing platforms and bioinformatics pipelines for
[3] SANA A,MEDA N,KAFANDO B,et al. Prevalence of compositional analysis of the gut microbiome[J]. BMC
COPD among women and relation with cooking fuel Microbiol,2017,17(1):194
choice in ouagadougou,burkina faso[J]. Int J Tuberc [17] WADE W G,PROSDOCIMI E M. Profiling of oral bacteri⁃
Lung Dis,2020,24(9):928-933 al communities[J]. J Dent Res,2020,99(6):621-629
[4] OLLOQUEQUI J,SILVA O R. Biomass smoke as a risk [18] HILTY M,BURKE C,PEDRO H,et al. Disordered micro⁃
factor for chronic obstructive pulmonary disease:effects bial communities in asthmatic airways[J]. PLoS One,
on innate immunity[J]. Innate Immun,2016,22(5): 2010,5(1):e8578
373-381 [19] LI X,SUN Y,AN Y,et al. Air pollution during the winter
[5] PATHAK U,GUPTA N C,SURI J C. Risk of COPD due period and respiratory tract microbial imbalance in a
to indoor air pollution from biomass cooking fuel:a sys⁃ healthy young population in Northeastern China[J]. Envi⁃
tematic review and meta ⁃ analysis[J]. Int J Environ ron Pollut,2019,246:972-979
Health Res,2020,30(1):75-88 [20] LEE S Y,MAC A M,FAM K D,et al. Airway microbiome
[6] LEUNG J M,TIEW P Y,MAC A M,et al. The role of composition correlates with lung function and arterial stiff⁃
acute and chronic respiratory colonization and infections ness in an age⁃dependent manner[J]. PLoS One,2019,14
in the pathogenesis of COPD[J]. Respirology,2017,22 (11):e225636