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               ·1842 ·                           南 京    医 科 大 学 学         报                        2021年12月


                   cle to the arterial pole of the developing heart[J]. Dev Bi⁃  ty⁃related drug attrition:the use of in vitro pharmacologi⁃
                   ol,2005,281(1):78-90                              cal profiling[J]. Nat Rev Drug Discov,2012,11(12):
             [25] SPÄTER D,HANSSON E M,ZANGI L,et al. How to         909-922
                   make a cardiomyocyte[J]. Development,2014,141(23):  [38] LAVERTY H,BENSON C,CARTWRIGHT E,et al. How
                   4418-4431                                         can we improve our understanding of cardiovascular safe⁃
             [26] LEE J,SUTANI A,KANEKO R,et al. In vitro generation  ty liabilities to develop safer medicines?[J]. Br J Pharma⁃
                   of functional murine heart organoids via FGF4 and extra⁃  col,2011,163(4):675-693
                   cellular matrix[J]. Nat Commun,2020,11(1):42-63  [39]EWART L,DEHNE E M,FABRE K,et al. Application of
             [27] DRAKHLIS L,BISWANATH S,FARR C M,et al. Hu⁃         microphysiological systems to enhance safety assessment
                   man heart⁃forming organoids recapitulate early heart and  in drug discovery[J]. Annu Rev Pharmacol Toxicol,
                   foregut development[J]. Nat Biotechnol,2021,39(6):  2018,58(6):65-82

                   737-746                                      [40] LAL⁃NAG M,MCGEE L,GUHA R,et al. A high⁃through⁃
             [28] LAWLOR K T,VANSLAMBROUCK J M,HIGGINS J W,          put screening model of the tumor microenvironment for
                   et al. Cellular extrusion bioprinting improves kidney or⁃  ovarian cancer cell growth[J]. SLAS Discov,2017,22
                   ganoid reproducibility and conformation[J]. Nat Mater,  (5):494-506

                   2021,20(2):260-271                           [41] DOBROLECKI L E,AIRHART S D,ALFEREZ D G,et
             [29] NOOR N,SHAPIRA A,EDRI R,et al. 3D printing of per⁃  al. Patient⁃derived xenograft(PDX)models in basic and
                   sonalized thick and perfusable cardiac patches and hearts  translational breast cancer research[J]. Cancer Metasta⁃
                  [J]. Adv Sci(Weinh),2019,6(11):190-204             sis Rev,2016,35(4):547-573
             [30] LEE A,HUDSON A R,SHIWARSKI D J,et al. 3D bio⁃  [42] SKARDAL A,ALEMAN J,FORSYTHE S,et al. Drug
                   printing of collagen to rebuild components of the human  compound screening in single and integrated multi⁃organ⁃
                   heart[J]. Science,2019,365(6452):482-487          oid body⁃on⁃a⁃chip systems[J]. Biofabrication,2020,12
             [31] LINDSEY M L,DE CASTRO BRAS L E,DELEON⁃PEN⁃        (2):25-37
                   NELL K Y,et al. Reperfused vs. non⁃reperfused myocar⁃  [43] MILLS R J,PARKER B L,QUAIFE⁃RYAN G A,et al.
                   dial infarction:when to use which model[J]. Am J Physi⁃  Drug screening in human PSC⁃cardiac organoids identi⁃
                   ol Heart Circ Physiol,2021,31(12):157-169         fies pro⁃proliferative compounds acting via the mevalon⁃
             [32] ADAMS C P,BRANTNER V V. Spending on new drug de⁃   ate pathway[J]. Cell Stem Cell,2019,24(6):895-907
                   velopment1[J]. Health Econ,2010,19(2):130-141  [44] NIE Y Z,ZHENG Y W,OGAWA M,et al. Human liver
             [33] LAN F,LEE A S,LIANG P,et al. Abnormal calcium han⁃  organoids generated with single donor ⁃ derived multiple
                   dling properties underlie familial hypertrophic cardiomy⁃  cells rescue mice from acute liver failure[J]. Stem Cell
                   opathy pathology in patient ⁃ specific induced pluripotent  Res Ther,2018,9(1):51-65
                   stem cells[J]. Cell Stem Cell,2013,12(1):101-113  [45] GAO L,GREGORICH Z R,ZHU W,et al. Large cardiac
             [34] FILIPPO BUONO M,VON BOEHMER L,STRANG J,et          muscle patches engineered from human induced⁃pluripo⁃
                   al. Human cardiac organoids for modeling genetic cardio⁃  tent stem cell⁃derived cardiac cells improve recovery from
                   myopathy[J]. Cells,2020,9(7):178-190              myocardial infarction in swine[J]. Circulation,2018,137
             [35] TZATZALOS E,ABILEZ O J,SHUKLA P,et al. Engi⁃      (16):1712-1730
                   neered heart tissues and induced pluripotent stem cells:  [46] JABS J,ZICKGRAF F M,PARK J,et al. Screening drug
                   macro ⁃ and microstructures for disease modeling,drug  effects in patient⁃derived cancer cells links organoid re⁃
                   screening,and translational studies[J]. Adv Drug Deliv  sponses to genome alterations[J]. Mol Syst Biol,2017,13
                   Rev,2016,96(2):34-44                             (11):955-968
             [36] SHINNAWI R,SHAHEEN N,HUBER I,et al. Modeling  [47] SAKAGUCHI H,KADOSHIMA T,SOEN M,et al. Gener⁃
                   reentry in the short QT syndrome with human ⁃ induced  ation of functional hippocampal neurons from self⁃organiz⁃
                   pluripotent stem cell⁃derived cardiac cell sheets[J]. J Am  ing human embryonic stem cell⁃derived dorsomedial tel⁃
                   Coll Cardiol,2019,73(18):2310-2324                encephalic tissue[J]. Nat Commun,2015,6(8):88-96
             [37] BOWES J,BROWN A J,HAMON J,et al. Reducing safe⁃                         [收稿日期] 2021-07-19
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