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               ·890 ·                            南 京    医 科 大 学 学         报                        2022年6月


                   cin⁃induced cell apoptosis in pancreatic cancer by inhibit⁃  [31] ZHANG Y,XIE C,WANG H,et al. Irisin exerts dual
                   ing the PI3K/AKT/NF⁃ κB pathway[J]. Med Sci Monit,  effects on browning and adipogenesis of human white adi⁃

                   2019,25:6085-6096                                 pocytes[J]. Am J Physiol Endocrinol Metab,2016,311
             [18] DIMITRIADIS G,MARATOU E,KOUNTOURI A,et al.        (2):E530-541
                   Regulation of postabsorptive and postprandial glucose me⁃  [32] LI H,ZHANG Y,WANG F,et al. Effects of irisin on the
                   tabolism by insulin ⁃ dependent and insulin ⁃ independent  differentiation and browning of human visceral white adi⁃
                   mechanisms:an integrative approach [J]. Nutrients,  pocytes[J]. Am J Transl Res,2019,11(12):7410-7421
                   2021,13(1):159                               [33] TSAI Y C,WANG C W,WEN B Y,et al. Involvement of
             [19] EDGERTON D S,MOORE M C,GREGORY J M,et al.          the p62/Nrf2/HO⁃1 pathway in the browning effect of
                   Importance of the route of insulin delivery to its control of  irisin in 3T3 ⁃ L1 adipocytes[J]. Mol Cell Endocrinol,
                   glucose metabolism[J]. Am J Physiol Endocrinol Metab,  2020,514:110915
                   2021,320(5):E891-E897                        [34] LIU T Y,SHI C X,GAO R,et al. Irisin inhibits hepatic
             [20] HAN H S,KANG G,KIM J S,et al. Regulation of glucose  gluconeogenesis and increases glycogen synthesis via the
                   metabolism from a liver⁃centric perspective[J]. Exp Mol  PI3K/Akt pathway in type 2 diabetic mice and hepatocytes
                   Med,2016,48:e218                                 [J]. Clin Sci(Lond),2015,129(10):839-850
             [21] TUPS A,BENZLER J,SERGI D,et al. Central regulation  [35] MO L,SHEN J,LIU Q,et al. Irisin is regulated by CAR
                   of glucose homeostasis[J]. Compr Physiol,2017,7(2):  in liver and is a mediator of hepatic glucose and lipid me⁃
                   741-764                                           tabolism[J]. Mol Endocrinol,2016,30(5):533-542
             [22] PANG Y,ZHU H,XU J,et al. β⁃arrestin⁃2 is involved in  [36] CHOE S S,CHOI A H,LEE J W,et al. Chronic activation
                   irisin induced glucose metabolism in type 2 diabetes via  of liver X receptor induces beta⁃cell apoptosis through hy⁃
                   p38 MAPK signaling[J]. Exp Cell Res,2017,360(2):  peractivation of lipogenesis:liver X receptor⁃mediated li⁃
                   199-204                                           potoxicity in pancreatic beta⁃cells[J]. Diabetes,2007,56
             [23] NATALICCHIO A,MARRANO N,BIONDI G,et al. The       (6):1534-1543
                                                                                                 +
                   myokine irisin is released in response to saturated fatty  [37] LI D J,SUN S J,FU J T,et al. NAD ⁃boosting therapy
                   acids and promotes pancreatic β⁃cell survival and insulin  alleviates nonalcoholic fatty liver disease via stimulating
                   secretion[J]. Diabetes,2017,66(11):2849-2856      a novel exerkine Fndc5/irisin[J]. Theranostics,2021,11
             [24] HOLLOSZY J O. Regulation of mitochondrial biogenesis  (9):4381-4402
                   and GLUT4 expression by exercise[J]. Compr Physiol,  [38] LIU T Y,XIONG X Q,REN X S,et al. FNDC5 alleviates
                   2011,1(2):921-940                                 hepatosteatosis by restoring AMPK/mTOR ⁃ mediated au⁃
             [25] HUH J Y,MOUGIOS V,KABASAKALIS A,et al. Exer⁃       tophagy,fatty acid oxidation,and lipogenesis in mice[J].
                   cise⁃induced irisin secretion is independent of age or fit⁃  Diabetes,2016,65(11):3262-3275
                   ness level and increased irisin may directly modulate mus⁃  [39] SO W Y,LEUNG P S. Irisin ameliorates hepatic glucose/
                   cle metabolism through AMPK activation[J]. J Clin Endo⁃  lipid metabolism and enhances cell survival in insulin⁃re⁃
                   crinol Metab,2014,99(11):E2154-E2161              sistant human HepG2 cells through adenosine monophos⁃
             [26] YE X,SHEN Y,NI C,et al. Irisin reverses insulin resis⁃  phate ⁃ activated protein kinase signaling[J]. Int J Bio⁃
                   tance in C2C12 cells via the p38⁃MAPK⁃PGC⁃1α pathway  chem Cell Biol,2016,78:237-247
                  [J]. Peptides,2019,119:170120                 [40] TANG H,YU R,LIU S,et al. Irisin inhibits hepatic cho⁃
             [27] KIM N,LEE J O,LEE H J,et al. AMPK,a metabolic sen⁃  lesterol synthesis via AMPK⁃SREBP2 signaling[J]. EBio⁃
                   sor,is involved in isoeugenol⁃induced glucose uptake in  Medicine,2016,6:139-148
                   muscle cells[J]. J Endocrinol,2016,228(2):105-114  [41] ZHANG D,XIE T,LEUNG P S. Irisin ameliorates glucoli⁃
             [28] LEEH J,LEEJO,KIM N,et al. Irisin,a novel myokine,regu⁃  potoxicity⁃associated β⁃cell dysfunction and apoptosis via
                   lates glucose uptake in skeletal muscle cells via AMPK  AMPK signaling and anti⁃inflammatory actions[J]. Cell
                  [J]. Mol Endocrinol,2015,29(6):873-881             Physiol Biochem,2018,51(2):924-937
             [29] HANKIR M,KLINGENSPOR M. Brown adipocyte glu⁃  [42] LI D J,HUANG F,LU W J,et al. Metformin promotes iri⁃
                   cose metabolism:a heated subject[J]. EMBO Rep,2018,  sin release from murine skeletal muscle independently of
                   19(9):e46404                                     AMP⁃activated protein kinase activation[J]. Acta Physiol
             [30] 刘碧莲,刘      峰. 白色脂肪米色化及其在代谢平衡中的                   (Oxf),2015,213(3):711-721
                   调控作用[J]. 南京医科大学学报(自然科学版),2016,                                         [收稿日期] 2021-11-17
                   36(1):8-11                                                                  (本文编辑:陈汐敏)
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