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呼吸暂停或低通气后更有可能出现 SpO2 下降，因 2.10 其他指标
此，MOS评分异常合并其他疾病的儿童是否有OSA 除上述指标以外，还有一些IH评估指标也被报
还有待确认 。 道，但临床相关研究及应用较少（表1）。
［38］

表1 其他IH相关评估指标
Table 1 Other IH⁃related assessment indicators
Clinical indicator Clinical application and characteristic
SIT Integrating the time and degree of desaturation below a certain level and calculating the area under the desatu⁃
［41］
ration curve，which is the SIT . The SIT correlates well with T90 and T80 and may indirectly reflect the severity
of nocturnal hypoxia in patients ［41］ . However，to date，the literature on this indicator is limited，resulting in in⁃
sufficient progress in related areas.
The magnitude of SpO 2 decline，which is mainly used to assess the severity of OSA，discusses apnea and
Decrease in SpO2
hypoventilation separately，suggesting that we may need to consider the weighting of the two when assessing
the adverse consequences of OSA，and that we should not generalize ［42］ .
SpO2 ApEn ApEn is an indicator of the variability of the data，and in the field of sleep，SpO2 ApEn has been used to study
the connection between respiratory changes and functional brain activity during different sleep stages ［43］ . In
other studies，it is commonly used to analyze electroencephalogram（EEG）signals in normal people with epi⁃
［44］ ［45］
lepsy and Alzheimer’s patients . Different stages of disease or different states of the body may reflect
changes in EEG，and ApEn，if it can capture such changes，may be able to serve as a basis for the diagnosis
and identification of disease.
［46］
ODR and ORR ODR and ORR can describe the rate of change of oxygen saturation per second during hypoxia⁃reoxygenation .
Studies have shown that ODR and ORR correlate with blood pressure in patients with OSA ［45］ and that ODR is
［47］
an EDS predictor. However，since ODR values can only be calculated in a closed system，the coverage of
this index is not comprehensive enough.
ΔIx ΔIx，which represents the change between successive oxygen saturation（SaO2）data measured at constant time
intervals，has a high sensitivity for diagnosing OSA and can therefore be used to exclude the diagnosis of OSA，
but has a poor specificity，and is therefore currently recommended only as an adjunct to screening in the clinical
setting ［48］ .
［33-34］
DesDur DesDur is independently associated with CVD outcomes ，and is the best independent predictor of mortality
［49］
and indirectly to assess myocardial injury in patients with heart failure combined with OSA . However，Des⁃
Dur does not account for 3% oxygen desaturation and tends to overlook mild OSA.
DesSev DesSev is associated with daytime somnolence ［49］ ，risk of impaired alertness ［35］ ，diabetes mellitus ［50］ and myo⁃
cardial damage ［49］ . However，as with DesDur，DesSev tends to ignore mild OSA，and because DesSev can also
capture hypoxia induced by other non⁃OSA conditions（cardiovascular or respiratory comorbidities），this leads
to an overestimation of the associated desaturated area.
［51］
REDTA REDTA defined as the sum of the areas between the SpO 2 trace and the 100% oxygen desaturation baseline
for all artificially scored respiratory events divided by 3 600，and primarily quantifies the duration and
depth of oxygen desaturation associated with respiratory events and the number of respiratory events，and
therefore can be used to measure nocturnal hypoxic injury. Chazal et al. ［51］ suggested that REDTA could pre⁃
dict CVD，but there have been fewer subsequent related studies.
［33］
AHDI ADHI is the sum of the percentage of apnea，hypoventilation，and oxygen desaturation time in total sleep
time，and unlike the AHI，it takes the duration of oxygen desaturation into account，which distinguishes well
between healthy individuals and patients with OSA. However，the degree of oxygen desaturation is not elaborated
in the AHDI，and the literature on the AHDI is limited to date，with a lack of further research progress reported in
this area.

SIT：saturation impairment time；SpO2 ApEn：approximate entropy of oxygen saturation；ODR：oxygen desaturation rate；ORR：oxygen resaturation
rate；ΔIx：oxygen saturation variability index；DesDur：desaturation duration；DesSev：desaturation severity；REDTA：the respiratory event desaturation
transient area；AHDI：apnea⁃hypopnea desaturation index.