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第45卷第11期 马晓月,杨宇帆,陈永欣. GPX4在非酒精性脂肪肝病中的作用机制及中药提取物干预研究[J].
2025年11月 南京医科大学学报(自然科学版),2025,45(11):1678-1688 ·1687 ·
21 attenuates iron overload⁃induced liver injury and fibro⁃ tin⁃induced ferroptosis by suppressing system Xc[J]. Cell
sis by inhibiting ferroptosis[J]. Redox Biol,2021,46: Death Differ,2020,27(2):662-675
102131 [40]WANG D X,WEI Y Q,WANG T T,et al. Melatonin atten⁃
[29]LUO Y L,CHEN H J,LIU H,et al. Protective effects of uates(⁃)⁃epigallocatehin⁃3⁃gallate⁃triggered hepatotoxici⁃
ferroptosis inhibition on high fat diet⁃induced liver and re⁃ ty without compromising its downregulation of hepatic glu⁃
nal injury in mice[J]. Int J Clin Exp Pathol,2020,13 coneogenic and lipogenic genes in mice[J]. J Pineal Res,
(8):2041-2049 2015,59(4):497-507
[30]SUN X F,OU Z H,CHEN R C,et al. Activation of the p62⁃ [41]SHOROBI F M,NISA F Y,SAHA S,et al. Quercetin:a
Keap1⁃NRF2 pathway protects against ferroptosis in hepa⁃ functional food⁃flavonoid incredibly attenuates emerging
tocellular carcinoma cells[J]. Hepatology,2016,63(1): and re⁃emerging viral infections through immunomodula⁃
173-184 tory actions[J]. Molecules,2023,28(3):938
[31]BAI T,WANG S,ZHAO Y P,et al. Haloperidol,a sigma [42]QI W D,QI W X,XIONG D W,et al. Quercetin:its anti⁃
receptor 1 antagonist,promotes ferroptosis in hepatocellu⁃ oxidant mechanism,antibacterial properties and potential
lar carcinoma cells[J]. Biochem Biophys Res Commun, application in prevention and control of toxipathy[J]. Mol⁃
2017,491(4):919-925 ecules,2022,27(19):6545
[32]GUO J,XU S. Astragaloside Ⅳ suppresses histamine⁃in⁃ [43]LI N C,CUI C,XU J,et al. Quercetin intervention re⁃
duced inflammatory factors and mucin 5 subtype AC over⁃ duced hepatic fat deposition in patients with nonalcoholic
production in nasal epithelial cells via regulation of in⁃ fatty liver disease:a randomized,double⁃blind,placebo⁃
flammation ⁃ related genes[J]. Bioengineered,2021,12 controlled crossover clinical trial[J]. Am J Clin Nutr,
(1):6045-6056 2024,120(3):507-517
[33]LIANG X Y,HONG F F,YANG S L. Astragaloside Ⅳ [44]YANG D Y,WANG T C,LONG M,et al. Quercetin:its
alleviates liver inflammation,oxidative stress and apopto⁃ main pharmacological activity and potential application
sis to protect against experimental non⁃alcoholic fatty liver in clinical medicine[J]. Oxid Med Cell Longev,2020,
disease[J]. Diabetes Metab Syndr Obes,2021,14:1871- 2020:8825387
1883 [45]HUANG T W,ZHANG K,WANG J Q,et al. Quercetin
[34]WANG X M,WANG Y L,HUANG D M,et al. Astragalo⁃ alleviates acrylamide ⁃ induced liver injury by inhibiting
side Ⅳ regulates the ferroptosis signaling pathway via the autophagy⁃dependent ferroptosis[J]. J Agric Food Chem,
Nrf2/SLC7A11/GPX4 axis to inhibit PM 2.5⁃mediated lung 2023,71(19):7427-7439
injury in mice[J]. Int Immunopharmacol,2022,112: [46]YE Y R,JIANG M Z,HONG X Y,et al. Quercetin allevi⁃
109186 ates deoxynivalenol ⁃ induced intestinal damage by sup⁃
[35]LEGEAY S,RODIER M,FILLON L,et al. Epigallocate⁃ pressing inflammation and ferroptosis in mice[J]. J Agric
chin gallate:a review of its beneficial properties to pre⁃ Food Chem,2023,71(28):10761-10772
vent metabolic syndrome[J]. Nutrients,2015,7(7): [47]AN N,ZHANG G X,LI Y J,et al. Promising antioxidative
5443-5468 effect of berberine in cardiovascular diseases[J]. Front
[36]NAITO Y,USHIRODA C,MIZUSHIMA K,et al. Epigal⁃ Pharmacol,2022,13:865353
locatechin ⁃ 3 ⁃ gallate(EGCG)attenuates non ⁃ alcoholic [48]YANG S,CAO S J,LI C Y,et al. Berberrubine,a main
fatty liver disease via modulating the interaction between metabolite of berberine,alleviates non⁃alcoholic fatty liver
gut microbiota and bile acids[J]. J Clin Biochem Nutr, disease via modulating glucose and lipid metabolism and
2020,67(1):2-9 restoring gut microbiota[J]. Front Pharmacol,2022,13:
[37]HE H,WANG L,QIAO Y,et al. Epigallocatechin⁃3⁃gal⁃ 913378
late pretreatment alleviates doxorubicin⁃induced ferropto⁃ [49]CHANDIRASEGARAN G,ELANCHEZHIYAN C,GHOSH
sis and cardiotoxicity by upregulating AMPKα2 and acti⁃ K. Effects of berberine chloride on the liver of streptozoto⁃
vating adaptive autophagy[J]. Redox Biol,2021,48: cin ⁃ induced diabetes in albino Wistar rats[J]. Biomed
102185 Pharmacother,2018,99:227-236
[38]YANG C J,WU A M,TAN L Q,et al. Epigallocatechin⁃3⁃ [50]BAO L,JIN Y X,HAN J N,et al. Berberine regulates
gallate alleviates liver oxidative damage caused by iron GPX4 to inhibit ferroptosis of islet β cells[J]. Planta
overload in mice through inhibiting ferroptosis[J]. Nutri⁃ Med,2023,89(3):254-261
ents,2023,15(8):1993 [51]DENG Y J,TANG K R,CHEN R S,et al. Berberine atten⁃
[39]WANG L Y,LIU Y C,DU T T,et al. ATF3 promotes eras⁃ uates hepatic oxidative stress in rats with non ⁃ alcoholic

