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第45卷第2期 蔡清清，尤含笑，王 磊，等. NLR和SII对抗MDA5抗体阳性皮肌炎伴快速进展型肺炎的预后价值［J］.
2025年2月 南京医科大学学报（自然科学版），2025，45（2）：196-207 ·201 ·
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表2 anti⁃MDA5 DM患者发生RPILD独立危险因素的单因素和多因素分析
Table 2 Univariate and multivariate analysis of the independent risk factors of RPILD in anti⁃MDA5 DM patients
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Univariate Multivariate
Variable
P HR（95%CI） P HR（95%CI）
Age 0.022 00 000 001.03（1.01-1.06） 0.141 1.02（0.99-1.05）
Sex 0.364 00 000 001.35（0.71-2.58） - -
NLR <0.001 00 000 001.13（1.06-1.20） 0.003 1.11（1.03-1.18）
PLR 0.012 00 000 001.00（1.00-1.00） - -
LMR 0.037 00 000 000.66（0.44-0.98） - -
SII 0.003 00 000 001.00（1.00-1.00） - -
SIRI 0.003 00 000 001.21（1.07-1.36） - -
AISI 0.015 00 000 001.00（1.00-1.00） - -
Myasthenia 0.179 00 000 001.56（0.82-2.98） - -
Gottron’s sign 0.084 00 000 000.57（0.30-1.08） 0.146 0.62（0.32-1.18）
Heliotrope rash 0.068 00 000 000.54（0.28-1.05） 0.156 0.61（0.31-1.21）
V sign 0.658 00 000 000.86（0.43-1.70） - -
Shawl sign 0.220 00 000 000.58（0.24-1.39） - -
Skin erythema 0.369 00 000 000.78（0.35-1.48） - -
Raynaud’s phenomenon 0.716 00 000 000.69（0.10-5.04 - -
Periungual erythema 0.380 00 000 000.66（0.26-1.68） - -
Arthritis 0.442 00 000 000.76（0.35-1.58） - -
Mechanic’s hand 0.239 00 000 000.66（0.32-1.33） - -
Heterotopic calcification 0.998 00 000 000.00（0-Inf） - -
Skin ulcer 0.227 00 000 000.53（0.19-1.49） - -
Hypertension 0.534 00 000 001.26（0.61-2.60） - -
Diabetes 0.423 00 000 000.62（0.19-2.01） - -
Malignant tumor 0.996 00 000 000.00（0-Inf） - -
Cardiac involvement 0.234 00 000 000.30（0.04-2.18） - -
ILD 0.996 79 944 617.47（0-Inf） - -
Glu 0.202 00 000 001.55（0.79-3.05） - -
PLR：platelet⁃to⁃lymphocyte ratio；NLR：neutrophil⁃to⁃lymphocyte ratio；LMR：lymphocyte⁃to⁃monocyte ratio；SII：systemic immune⁃inflammation
index；SIRI：systemic inflammation response index；ILD：interstitial lung disease；Glu：glucose；Inf：infinity；CI：confidence interval.
3B）. the current study，we aimed to screen prognostic fac⁃
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tors affecting anti⁃MDA5 DM and highlight its poten⁃
3 Discussion
tial significance in clinical practice.
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Anti⁃MDA5 DM is frequently associated with in⁃ We found that the NLR was the most significant
terstitial lung disease，particularly RPILD which has prognostic biomarker for RPILD in patients with anti⁃
［1］ +
impressively high mortality . The interactions of pe⁃ MDA5 DM. According to previous studies，NLR was an
ripheral blood cells play a crucial role in regulating in⁃ important marker for evaluating the activity of RA ［41- 42］
flammation and immune responses. Neutrophils，lym⁃ and predicting the risk of death ［43］ . Additionally，NLR
phocytes，and platelets are vital effector cells in the was associated with the activity of leukoaraiosis syn⁃
［38- 40］ ［44- 45］ ［46- 47］
inflammatory response . Consequently，the derived drome and a predictor of psoriatic arthritis . It
inflammatory indices，such as NLR and SII，have has also been correlated with the activity of systemic
gained attention for their ability to comprehensively as⁃ lupus erythematosus and the prediction of lupus ne⁃
［48］
sess the inflammatory status in patients with systemic phritis . In cases of pulmonary fibrosis in ILD，fibro⁃
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autoimmune diseases，including anti⁃MDA5 DM . In blasts and myofibroblasts proliferate and deposit exces⁃
