Page 168 - 《南京医科大学学报》2026年第1期
P. 168
第46卷第1期
· 162 · 南 京 医 科 大 学 学 报 2026年1月
1858(7):519-528 [65]RAGHUBEER S,NAGIAH S,PHULUKDAREE A,et al.
[54]VENKATESH S,LI M,SAITO T,et al. Mitochondrial The phytoalexin resveratrol ameliorates ochratoxin a toxic⁃
LONP1 protects cardiomyocytes from ischemia/reperfu⁃ ity in human embryonic kidney(HEK293)cells[J]. J Cell
sion injury in vivo[J]. J Mol Cell Cardiol,2019,128:38- Biochem,2015,116(12):2947-2955
50 [66]KIM J E,PARK H,KIM T H,et al. LONP1 regulates mi⁃
[55]ONAT U I,YILDIRIM A D,TUFANLI Ö,et al. Intercept⁃ tochondrial accumulations of HMGB1 and Caspase⁃ 3 in
ing the lipid⁃induced integrated stress response reduces CA1 and PV neurons following status epilepticus[J]. Int
atherosclerosis[J]. J Am Coll Cardiol,2019,73(10): J Mol Sci,2021,22(5):2275
1149-1169 [67]WANG W Z,MA X P,BHATTA S,et al. Intraneuronal β⁃
[56]HOSHINO A,OKAWA Y,ARIYOSHI M,et al. Oxidative amyloid impaired mitochondrial proteostasis through the
post⁃translational modifications develop LONP1 dysfunc⁃ impact on LONP1[J]. Proc Natl Acad Sci U S A,2023,
tion in pressure overload heart failure[J]. Circ Heart Fail, 120(51):e2316823120
2014,7(3):500-509 [68]XU D,ZHANG Z,ZHU Z,et al. Decreased LONP1 ex⁃
[57]LI M K,ZHANG W K,ZHANG M H,et al. LONP1 facili⁃ pression exacerbates MASH⁃induced liver fibrosis via ele⁃
tates pulmonary artery smooth muscle cell glycolytic re⁃ vated orotic acid levels[J]. J Hepatol,2025,8:0168⁃8278
programming by degrading MPC1 in pulmonary hyperten⁃ (25)02379-7
sion[J]. Clin Sci(Lond),2025,139(10):479-501 [69]WU M C,WU J,LIU K,et al. LONP1 ameliorates liver in⁃
[58]XU Z S,FU T T,GUO Q Q,et al. Disuse⁃associated loss jury and improves gluconeogenesis dysfunction in acute⁃
of the protease LONP1 in muscle impairs mitochondrial on⁃chronic liver failure[J]. Chin Med J(Engl),2024,137
function and causes reduced skeletal muscle mass and (2):190-199
strength[J]. Nat Commun,2022,13(1):894 [70]HOU Q,CHENG S,LI Z,et al. Peste des petits ruminants
[59]HUANG S Y,WANG X N,YU J L,et al. LonP1 regulates virus(PPRV)induces ferroptosis via LONP1 ⁃ mediated
mitochondrial network remodeling through the PINK1/ mitochondrial GPX4 degradation in cell culture[J]. J Vi⁃
Parkin pathway during myoblast differentiation[J]. Am J rol,2025,99(5):e0231024
Physiol Cell Physiol,2020,319(6):C1020-c1028 [71]LI J,DENG Y,GASSER M,et al. LONP1 regulation of mi⁃
[60]KNUTH C M,AUGER C,JESCHKE M G. Burn⁃induced tochondrial protein folding provides insight into beta cell
hypermetabolism and skeletal muscle dysfunction[J]. failure in type 2 diabetes[J]. Nat Metab,2025,7(8):
Am J Physiol Cell Physiol,2021,321(1):C58-C71 1570-1592
[61]HE Y Z,DING Q H,CHEN W L,et al. LONP1 downregu⁃ [72]FAN J,XU X,LI Y,et al. A novel 3⁃phenylglutaric acid
lation with ageing contributes to osteoarthritis via mito⁃ derivative(84 ⁃ B10)alleviates cisplatin ⁃ induced acute
chondrial dysfunction[J]. Free Radic Biol Med,2022, kidney injury by inhibiting mitochondrial oxidative stress⁃
191:176-190 mediated ferroptosis[J]. Free Radic Biol Med,2023,194:
[62]GONG W,SONG J Y,LIANG J,et al. Reduced Lon prote⁃ 84-98
ase 1 expression in podocytes contributes to the pathogen⁃ [73]XU X Y,ZHU W P,MIAO M Q,et al. Activation of
esis of podocytopathy[J]. Kidney Int,2021,99(4):854- LONP1 by 84⁃B10 alleviates aristolochic acid nephropa⁃
869 thy via re⁃establishing mitochondrial and peroxisomal ho⁃
[63]BAI M,WU M,JIANG M,et al. LONP1 targets HMGCS2 meostasis[J]. Chin J Nat Med,2024,22:808-821
to protect mitochondrial function and attenuate chronic [74]SU M,LIU X R,ZHAO Y R,et al. In silico and in vivo
kidney disease[J]. EMBO Mol Med,2023,15(2):16581 pharmacokinetic evaluation of 84⁃B10,a novel drug can⁃
[64]ZHANG B Y,SHEN X L,LIANG R,et al. Protective role didate against acute kidney injury and chronic kidney dis⁃
of the mitochondrial LON protease 1 in ochratoxin A⁃in⁃ ease[J]. Molecules,2023,29(1):159
duced cytotoxicity in HEK293 cells[J]. J Proteomics, (收稿:2025-08-18;修回:2025-11-13;录用:2025-11-17)
2014,101:154-168 (本文编辑:唐 震)

