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第46卷第9期 万丽娟,李金凯,苏国义,等. 基于临床及剂量学特征构建模型预测鼻咽癌放疗后颞叶损伤的研究[J].
                  2026年9月                     南京医科大学学报(自然科学版),2026,46(9):1348-1355                      ·1351 ·


                                            表1 365例鼻咽癌患者的一般资料及剂量体积参数
                        Table 1 General information and dose⁃volume parameters of 365 nasopharyngeal carcinoma patients
                                                                                                   [n(%),x ± s]
                                                                                          2
                           Characteristic           TLI group       Non⁃TLI group        χ /t/Z          P
                    Sex[n(%)]                                                           χ =0.410        0.522
                                                                                         2
                     Male                           33(78.6)        0.239(74.0)0.
                     Female                         09(21.4)         0.84(26.0).
                    Age(years,x ± s)                52.8 ± 9.8       53.0 ± 12.6        t=0.080         0.937
                    Chemotherapy regimen[n(%)]                                         Z=-0.602         0.547
                     Radiotherapy only               1(2.4)           10(3.1)
                     Concurrent chemoradiotherapy   22(52.4)         149(46.1)
                     Induction chemotherapy         19(45.2)         164(50.8)
                    Hypertension[n(%)]                                                  χ =0.126        0.722
                                                                                         2
                     Yes                            12(28.6)         0.84(26.0).
                     No                             30(71.4)        0.239(74.0)0.
                    Diabetes[n(%)]                                                      χ =0.333        0.564
                                                                                         2
                     Yes                             4(9.5)           30(9.3)
                     No                             38(90.5)         293(90.7)
                    Hyperlipidemia[n(%)]                                                χ =0.002        0.966
                                                                                         2
                     Yes                            07(16.7)         053(16.4)
                     No                             35(83.3)         270(83.6)
                    Clinical stages[n(%)]                                              Z=-1.058         0.290
                     Stage Ⅰ                         0(0)0.           02(0.6)
                     Stage Ⅱ                         1(2.4)          036(11.2)
                     Stage Ⅲ                        20(47.6)         138(42.7)
                     Stage Ⅳ                        21(50)0.         147(45.5)
                    T stage[n(%)]                                                      Z=-2.664         0.008
                     T1 stage                        3(7.1)          060(18.6)
                     T2 stage                        3(7.1)          069(21.4)
                     T3 stage                       19(45.2)         098(30.3)
                     T4 stage                       17(40.5)         096(29.7)
                    N stage[n(%)]                                                      Z=-1.029         0.304
                                                    06(14.3)         0.13(4.0)0.
                     N0
                                                    10(23.8)         111(34.4)
                     N1
                                                    21(50)0.         132(40.9)
                     N2
                                                    05(11.9)         067(20.7)
                     N3
                    M stage                                                            Z=-0.569         0.569
                                                    40(95.2)         313(96.9)
                     M0
                                                     2(4.8)           10(3.1)
                     M1
                    Radiotherapy modality[n(%)]                                        Z=-1.179         0.239
                     IMRT                           17(40.5)         162(50.2)
                     VMAT                           25(59.5)         161(49.8)
                    Total radiation dose(x ± s)     66.3 ± 5.9       64.5 ± 5.10        t=-2.149        0.032
                    D (Gy,x ± s)                    72.0 ± 5.3       65.9 ± 5.50        t=-6.650       <0.001
                     1 cm 3
                    Dmean (Gy,x ± s)                17.6 ± 4.6       15.2 ± 4.00        t=-3.596       <0.001
                    Dmax (Gy,x ± s)                 75.2 ± 4.6       71.0 ± 4.40        t=-5.767       <0.001
                    Dmin (Gy,x ± s)                 01.2 ± 0.4        1.1 ± 0.5         t=-0.227        0.821
                    V40 Gy (%,x ± s)                14.2 ± 5.4       10.9 ± 4.60        t=-4.276       <0.001
                    V70 Gy (%,x ± s)                03.0 ± 2.5        0.8 ± 1.4         t=-8.534       <0.001
                    D1% (Gy,x ± s)                  71.0 ± 6.1       65.8 ± 5.60        t=-5.610       <0.001
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