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第46卷第9期 万丽娟,李金凯,苏国义,等. 基于临床及剂量学特征构建模型预测鼻咽癌放疗后颞叶损伤的研究[J].
2026年9月 南京医科大学学报(自然科学版),2026,46(9):1348-1355 ·1351 ·
表1 365例鼻咽癌患者的一般资料及剂量体积参数
Table 1 General information and dose⁃volume parameters of 365 nasopharyngeal carcinoma patients
[n(%),x ± s]
2
Characteristic TLI group Non⁃TLI group χ /t/Z P
Sex[n(%)] χ =0.410 0.522
2
Male 33(78.6) 0.239(74.0)0.
Female 09(21.4) 0.84(26.0).
Age(years,x ± s) 52.8 ± 9.8 53.0 ± 12.6 t=0.080 0.937
Chemotherapy regimen[n(%)] Z=-0.602 0.547
Radiotherapy only 1(2.4) 10(3.1)
Concurrent chemoradiotherapy 22(52.4) 149(46.1)
Induction chemotherapy 19(45.2) 164(50.8)
Hypertension[n(%)] χ =0.126 0.722
2
Yes 12(28.6) 0.84(26.0).
No 30(71.4) 0.239(74.0)0.
Diabetes[n(%)] χ =0.333 0.564
2
Yes 4(9.5) 30(9.3)
No 38(90.5) 293(90.7)
Hyperlipidemia[n(%)] χ =0.002 0.966
2
Yes 07(16.7) 053(16.4)
No 35(83.3) 270(83.6)
Clinical stages[n(%)] Z=-1.058 0.290
Stage Ⅰ 0(0)0. 02(0.6)
Stage Ⅱ 1(2.4) 036(11.2)
Stage Ⅲ 20(47.6) 138(42.7)
Stage Ⅳ 21(50)0. 147(45.5)
T stage[n(%)] Z=-2.664 0.008
T1 stage 3(7.1) 060(18.6)
T2 stage 3(7.1) 069(21.4)
T3 stage 19(45.2) 098(30.3)
T4 stage 17(40.5) 096(29.7)
N stage[n(%)] Z=-1.029 0.304
06(14.3) 0.13(4.0)0.
N0
10(23.8) 111(34.4)
N1
21(50)0. 132(40.9)
N2
05(11.9) 067(20.7)
N3
M stage Z=-0.569 0.569
40(95.2) 313(96.9)
M0
2(4.8) 10(3.1)
M1
Radiotherapy modality[n(%)] Z=-1.179 0.239
IMRT 17(40.5) 162(50.2)
VMAT 25(59.5) 161(49.8)
Total radiation dose(x ± s) 66.3 ± 5.9 64.5 ± 5.10 t=-2.149 0.032
D (Gy,x ± s) 72.0 ± 5.3 65.9 ± 5.50 t=-6.650 <0.001
1 cm 3
Dmean (Gy,x ± s) 17.6 ± 4.6 15.2 ± 4.00 t=-3.596 <0.001
Dmax (Gy,x ± s) 75.2 ± 4.6 71.0 ± 4.40 t=-5.767 <0.001
Dmin (Gy,x ± s) 01.2 ± 0.4 1.1 ± 0.5 t=-0.227 0.821
V40 Gy (%,x ± s) 14.2 ± 5.4 10.9 ± 4.60 t=-4.276 <0.001
V70 Gy (%,x ± s) 03.0 ± 2.5 0.8 ± 1.4 t=-8.534 <0.001
D1% (Gy,x ± s) 71.0 ± 6.1 65.8 ± 5.60 t=-5.610 <0.001

