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表3 369例老年持续性AF患者射频消融术后1年复发的单、多因素Logistic回归分析
Table 3 Unvariated and multivariate logistic regression analysis of 1⁃year recurrence after radiofrequency ablation in 369
elderly patients with persistent AF
Univariate analysis Multivariate analysis
Variable
OR(95%CI) P OR(95%CI) P
Sex(male) 1.814(1.098-2.997) 0.020
No alcohol 0.438(0.207-0.925) 0.030
Duration of AF 1.023(1.014-1.031) <0.001 1.021(1.012-1.030) <0.001
f⁃wave amplitude in lead Ⅲ 0.960(0.947-0.972) <0.001
f⁃wave amplitude in lead avF(mV) 0.951(0.937-0.965) <0.001 0.965(0.949-0.981) <0.001
f⁃wave amplitude in lead V2(mV) 0.968(0.957-0.979) <0.001 0.978(0.966-0.991) 0.001
LAD 1.069(1.007-1.135) 0.028
RAD 1.053(0.984-1.127) 0.138
利益冲突声明:
1.0
所有作者均声明无利益冲突。
0.8 Conflict of Interests:
All authors declare no conflict of interests.
Sensitivity 作者贡献声明:
0.6
颜清负责数据整理、统计分析及撰写文章初稿。王世
0.4
新、李新收集数据和统计分析。王林林、陈红武、陈明龙提出
并设计研究方案,对文章进行修改和审核。
avF AUC=0.775
0.2
V2 AUC=0.733 Author’s Contributions:
Duration AUC=0.668
0 YAN Qing was responsible for data organization,statistical
analysis and writing the manuscript. WANG Shixin and LI Xin
0 0.2 0.4 0.6 0.8 1.0
1-Specificity collected data and conducted statistical analysis. WANG Linlin,
图 2 病程、avF 导联及 V2 导联 f 波振幅诊断射频消融术后 CHEN Hongwu,and CHEN Minglong proposed and designed
AF复发的ROC曲线 the research plan,and revised the manuscript.
Figure 2 ROC curves for diagnosing recurrence after
[参考文献]
radiofrequency ablation based on the duration
of AF and f⁃wave amplitudes in leads avF and [1] PACKER D L,PICCINI J P,MONAHAN K H,et al. Abla⁃
tion versus drug therapy for atrial fibrillation in heart fail⁃
V2
ure:results from the CABANA trial[J]. Circulation,
映 AF 患者的电重构及结构重构的程度。f 波振幅
2021,143(14):1377-1390
低,说明心房电活动更加复杂、碎裂,相应的预后也
[2] TURAGAM M K,MUSIKANTOW D,WHANG W,et al.
更差 [26] 。本研究亦表明f波振幅低的患者术后复发 Assessment of catheter ablation or antiarrhythmic drugs
率更高,通过f波的振幅可预测AF消融的效果。且 for first⁃line therapy of atrial fibrillation:a meta⁃analysis
体表心电图易于获取,结果易于解读,相比复杂的 of randomized clinical trials[J]. JAMA Cardiol,2021,6
机器学习算法,也更便于临床应用。 (6):697-705
本研究仍存在一些局限性。本研究为单中心 [3] CHEW D S,LI Y H,COWPER P A,et al. Cost⁃effective⁃
研究,纳入对象为老年持续性AF患者,研究范围较 ness of catheter ablation versus antiarrhythmic drug thera⁃
py in atrial fibrillation:the CABANA randomized clinical
窄,故而作患者数量相对较少。此外,为回顾性分
trial[J]. Circulation,2022,146(7):535-547
析,随访资料的完整性受到限制,需要大样本的前
[4] KUCK K H,LEBEDEV D S,MIKHAYLOV E N,et al.
瞻性研究进一步验证结果。
Catheter ablation or medical therapy to delay progression
综上,心电图及病程可评估老年持续性AF患者 of atrial fibrillation:the randomized controlled atrial fibril⁃
射频消融手术效果。avF导联、V2导联f波振幅越高, lation progression trial(ATTEST)[J]. Europace,2021,23
术后复发率越低;AF病程越长,术后复发率越高。 (3):362-369

