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第46卷第9期
               ·1346 ·                           南 京    医 科 大 学 学         报                        2026年9月


                             表3 369例老年持续性AF患者射频消融术后1年复发的单、多因素Logistic回归分析
              Table 3  Unvariated and multivariate logistic regression analysis of 1⁃year recurrence after radiofrequency ablation in 369
                      elderly patients with persistent AF

                                                      Univariate analysis              Multivariate analysis
                           Variable
                                                   OR(95%CI)           P            OR(95%CI)           P
                 Sex(male)                      1.814(1.098-2.997)    0.020
                 No alcohol                     0.438(0.207-0.925)    0.030
                 Duration of AF                 1.023(1.014-1.031)   <0.001      1.021(1.012-1.030)   <0.001
                 f⁃wave amplitude in lead Ⅲ     0.960(0.947-0.972)   <0.001
                 f⁃wave amplitude in lead avF(mV)  0.951(0.937-0.965)  <0.001    0.965(0.949-0.981)   <0.001
                 f⁃wave amplitude in lead V2(mV)  0.968(0.957-0.979)  <0.001     0.978(0.966-0.991)    0.001
                 LAD                            1.069(1.007-1.135)    0.028
                 RAD                            1.053(0.984-1.127)    0.138


                                                                    利益冲突声明:
                      1.0
                                                                    所有作者均声明无利益冲突。
                      0.8                                           Conflict of Interests:
                                                                    All authors declare no conflict of interests.
                      Sensitivity                                   作者贡献声明:
                      0.6
                                                                    颜清负责数据整理、统计分析及撰写文章初稿。王世
                      0.4
                                                                新、李新收集数据和统计分析。王林林、陈红武、陈明龙提出
                                                                并设计研究方案,对文章进行修改和审核。
                                      avF AUC=0.775
                      0.2
                                      V2  AUC=0.733                 Author’s Contributions:
                                      Duration AUC=0.668
                        0                                           YAN Qing was responsible for data organization,statistical
                                                                analysis and writing the manuscript. WANG Shixin and LI Xin
                          0    0.2  0.4  0.6  0.8   1.0
                                   1-Specificity                collected data and conducted statistical analysis. WANG Linlin,
              图 2  病程、avF 导联及 V2 导联 f 波振幅诊断射频消融术后               CHEN Hongwu,and CHEN Minglong proposed and designed
                   AF复发的ROC曲线                                   the research plan,and revised the manuscript.
              Figure 2  ROC curves for diagnosing recurrence after
                                                                [参考文献]
                        radiofrequency ablation based on the duration
                        of AF and f⁃wave amplitudes in leads avF and  [1] PACKER D L,PICCINI J P,MONAHAN K H,et al. Abla⁃
                                                                     tion versus drug therapy for atrial fibrillation in heart fail⁃
                        V2
                                                                     ure:results from the CABANA trial[J]. Circulation,
              映 AF 患者的电重构及结构重构的程度。f 波振幅
                                                                     2021,143(14):1377-1390
              低,说明心房电活动更加复杂、碎裂,相应的预后也
                                                                [2] TURAGAM M K,MUSIKANTOW D,WHANG W,et al.
              更差  [26] 。本研究亦表明f波振幅低的患者术后复发                           Assessment of catheter ablation or antiarrhythmic drugs
              率更高,通过f波的振幅可预测AF消融的效果。且                                for first⁃line therapy of atrial fibrillation:a meta⁃analysis
              体表心电图易于获取,结果易于解读,相比复杂的                                 of randomized clinical trials[J]. JAMA Cardiol,2021,6
              机器学习算法,也更便于临床应用。                                      (6):697-705
                  本研究仍存在一些局限性。本研究为单中心                           [3] CHEW D S,LI Y H,COWPER P A,et al. Cost⁃effective⁃
              研究,纳入对象为老年持续性AF患者,研究范围较                                ness of catheter ablation versus antiarrhythmic drug thera⁃
                                                                     py in atrial fibrillation:the CABANA randomized clinical
              窄,故而作患者数量相对较少。此外,为回顾性分
                                                                     trial[J]. Circulation,2022,146(7):535-547
              析,随访资料的完整性受到限制,需要大样本的前
                                                                [4] KUCK K H,LEBEDEV D S,MIKHAYLOV E N,et al.
              瞻性研究进一步验证结果。
                                                                     Catheter ablation or medical therapy to delay progression
                  综上,心电图及病程可评估老年持续性AF患者                              of atrial fibrillation:the randomized controlled atrial fibril⁃
              射频消融手术效果。avF导联、V2导联f波振幅越高,                             lation progression trial(ATTEST)[J]. Europace,2021,23
              术后复发率越低;AF病程越长,术后复发率越高。                               (3):362-369
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