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第42卷第5期 臧小栋，马思雨，胡擎晖，等. 长链非编码RNA在脑缺血再灌注损伤中调控神经元细胞自噬的
2022年5月 研究进展［J］. 南京医科大学学报（自然科学版），2022，42（05）：751-758 ·757 ·

Afadin ⁃ dependent oriented cell division［J］. Nat Com⁃ hypoxia⁃ischemia［J］. Autophagy，2010，6（3）：366-377
mun，2020，11（1）：3200 ［40］ ZHAO J，BRAULT J J，SCHILD A，et al. FoxO3 coordi⁃
［28］ HE T，LI W，SONG Y，et al. Sestrin2 regulates microglia nately activates protein degradation by the autophagic/ly⁃
polarization through mTOR ⁃ mediated autophagic flux to sosomal and proteasomal pathways in atrophying muscle
attenuate inflammation during experimental brain isch⁃ cells［J］. Cell Metab，2007，6（6）：472-483
emia［J］. J Neuroinflammation，2020，17（1）：329 ［41］ YU S，YU M，HE X，et al. KCNQ1OT1 promotes autopha⁃
［29］ DENG L，CHEN L，ZHAO L，et al. Ubiquitination of Rheb gy by regulating miR⁃200a/FOXO3/ATG7 pathway in ce⁃
governs growth factor ⁃ induced mTORC1 activation［J］. rebral ischemic stroke［J］. Aging cell，2019，18（3）：
Cell Res，2019，29：136-150 e12940
［30］ WANG W，LI J，TAN J，et al. Endonuclease G promotes ［42］ WU Y，HUANG Y，CAI J，et al. LncRNA SNHG12 im⁃
autophagy by suppressing mTOR signaling and activating proves cerebral ischemic⁃reperfusion injury by activating
the DNA damage response［J］. Nat Commun，2021，12 SIRT1/FOXO3a pathway through i nhibition of autophagy
（1）：476 and oxidative stress［J］. Curr Neurovasc Res，2020，17
［31］ HEI C，LIU P，YANG X，et al. Inhibition of mTOR signal⁃ （4）：394-401
ing confers protection against cerebral ischemic injury in ［43］ HUANG L，LIU Z，WANG L. Effects of ischemic post⁃con⁃
acute hyperglycemic rats［J］. Int J Biol Sci，2017，13： ditioning on the expressions of LC3⁃Ⅱ and Beclin⁃1 in
878-887 the hippocampus of rats after cerebral ischemia and reper⁃
［32］ WEI W，LU M，LAN X B，et al. Neuroprotective effects of fusion［J］. Open Life Sci，2019，14：179-190
oxymatrine on PI3K/Akt/mTOR pathway after hypoxic ⁃ ［44］ GUO D，MA J，YAN L，et al. Down⁃regulation of lncrna
ischemic brain damage in neonatal rats［J］. Front Pharma⁃ MALAT1 attenuates neuronal cell death through suppress⁃
col，2021，12：642415 ing beclin1⁃dependent autophagy by regulating mir⁃ 30a
［33］ YIN S，YANG S，PAN X，et al. MicroRNA155 promotes in cerebral ischemic stroke［J］. Cell Physiol Biochem，
oxLDLinduced autophagy in human umbilical vein endo⁃ 2017，43（1）：182-194
thelial cells by targeting the PI3K/Akt/mTOR pathway ［45］ MI Z，LIU H，ROSE M E，et al. Abolishing UCHL1's hy⁃
［J］. Mol Med Rep，2018，18（3）：2798-806 drolase activity exacerbates TBI ⁃ induced axonal injury
［34］ SHAO Y，YE M，LI Q，et al. LncRNA⁃RMRP promotes and neuronal death in mice［J］. Exp Neurol，2021，336：
carcinogenesis by acting as a miR⁃206 sponge and is used 113524
as a novel biomarker for gastric cancer［J］. Oncotarget， ［46］ KIM J，PIAO H L，KIM B J，et al. Long noncoding RNA
2016，7（25）：37812-37824 MALAT1 suppresses breast cancer metastasis［J］. Nat
［35］ MIYOSHI N，WAGATSUMA H，WAKANA S，et al. Iden⁃ Genet，2018，50（12）：1705-1715
tification of an imprinted gene，Meg3/Gtl2 and its human ［47］ TAN X，GUO W，PENG Z，et al. LncRNA⁃Malat1 down⁃
homologue MEG3，first mapped on mouse distal chromo⁃ regulates miR ⁃ 211 ⁃ 5p expression to promote neuronal
some 12 and human chromosome 14q［J］. Genes Cells， damage from cerebral ischemia reperfusion injury［J］. Bio⁃
2000，5（3）：211-220 chem Pharmacol，2021，192：114694
［36］ ZHAO H，WANG X，FENG X，et al. Long non ⁃ coding ［48］ ZHANG T，BEEHARRY M K，WANG Z，et al. YY1⁃mod⁃
RNA MEG3 regulates proliferation，apoptosis，and autoph⁃ ulated long non ⁃ coding RNA SNHG12 promotes gastric
agy and is associated with prognosis in glioma［J］. J Neu⁃ cancer metastasis by activating the miR⁃218⁃5p/YWHAZ
rooncol，2018，140（2）：281-288 axis［J］. Int J Biol Sci，2021，17（7）：1629-1643
［37］ GAO S，LI E，GAO H. Long non⁃coding RNA MEG3 at⁃ ［49］ WANG O，YANG F，LIU Y，et al. C⁃MYC⁃induced upreg⁃
tends to morphine ⁃ mediated autophagy of HT22 cells ulation of lncRNA SNHG12 regulates cell proliferation，
through modulating ERK pathway［J］. Pharm Biol，2019， apoptosis and migration in triple ⁃ negative breast cancer
57（1）：536-542 ［J］. Am J Transl Res，2017，9（2）：533-545
［38］ QIN N，TONG G F，SUN L W，et al. Long noncoding RNA ［50］ NICOLA A M，ALBUQUERQUE P，MARTINEZ L R，et
MEG3 suppresses glioma cell proliferation，migration， al. Macrophage autophagy in immunity to cryptococcus

and invasion by acting as a competing endogenous RNA neoformans and candida albicans［J］. Infec Immun，2012，
of miR⁃19a［J］. Oncol Res，2017，25（9）：1471-1478 80（9）：3065-3076
［39］ CARLONI S，GIRELLI S，SCOPA C，et al. Activation of ［51］ FISCHER S，RIJAL R，FROMMOLT P，et al. Functional
autophagy and Akt/CREB signaling play an equivalent characterization of ubiquitin⁃like core autophagy protein
role in the neuroprotective effect of rapamycin in neonatal ATG12 in dictyostelium discoideum］J］. Cells，2019，8