Page 137 - 南京医科大学学报自然科学版

第42卷第9期 周 滢，娄宇轩，孙 伟，等. 线粒体离子通道在心血管疾病中的研究进展［J］.
2022年9月 南京医科大学学报（自然科学版），2022，42（09）：1322-1334 ·1331 ·

cardiomyopathy：roles and mechanisms［J］. Front Cell regulates the molecular composition of the mitochondrial
Dev Biol，2021，9：750382 calcium uniporter channel to limit mitochondrial calcium
［81］ DILLMANN W H. Diabetic cardiomyopathy［J］. Circ Res， overload during stress［J］. Circulation，2019，140（21）：
2019，124（8）：1160-1162 1720-1733
［82］ DIAZ J，SUAREZ J，CIVIDINI F，et al. Expression of the ［94］ HAUSENLOY D J，MADDOCK H L，BAXTER G F，et al.
mitochondrial calcium uniporter in cardiac myocytes im⁃ Inhibiting mitochondrial permeability transition pore
proves impaired mitochondrial calcium handling and me⁃ opening：a new paradigm for myocardial preconditioning?
tabolism in simulated hyperglycemia［J］. Am J Physiol ［J］. Cardiovasc Res，2002，55（3）：534-543
Cell Physiol，2016，311（6）：1005-1013 ［95］ ARGAUD L，GATEAU ⁃ ROESCH O，RAISKY O，et al.
［83］ SUAREZ J，CIVIDINI F，SCOTT B T，et al. Restoring mi⁃ Postconditioning inhibits mitochondrial permeability tran⁃
tochondrial calcium uniporter expression in diabetic sition［J］. Circulation，2005，111（2）：194-197
mouse heart improves mitochondrial calcium handling ［96］ CALDERONE V，TESTAI L，MARTELLI A，et al. Anti⁃
and cardiac function［J］. J Biol Chem，2018，293（21）： ischemic properties of a new spiro⁃cyclic benzopyran acti⁃
8182-8195 vator of the cardiac mito ⁃ KATP channel［J］. Biochem
［84］ JI L，LIU F，JING Z，et al. MICU1 alleviates diabetic car⁃ Pharmacol，2010，79（1）：39-47
diomyopathy through mitochondrial Ca（2 +）⁃ dependent ［97］ CHEN X Y，WANG J Q，CHENG S J，et al. Diazoxide post
antioxidant response［J］. Diabetes，2017，66（6）：1586- ⁃conditioning activates the HIF⁃1/HRE pathway to induce
1600 myocardial protection in hypoxic/reoxygenated cardiomyo⁃
［85］ ANDERSON E J，RODRIGUEZ E，ANDERSON C A，et cytes［J］. Front Cardiovasc Med，2021，8：711465
al. Increased propensity for cell death in diabetic human ［98］ LI J，ZHOU W，CHEN W，et al. Mechanism of the hypoxia
heart is mediated by mitochondrial ⁃ dependent pathways inducible factor 1/hypoxic response element pathway in
［J］. Am J Physiol Heart Circ Physiol，2011，300（1）： rat myocardial ischemia/diazoxide postconditioning［J］.
H118-124 Mol Med Rep，2020，21（3）：1527-1536
2+
［86］ FANCHER I S，DICK G M，HOLLANDER J M. Diabetes ［99］ SATO T，SAITO T，SAEGUSA N，et al. Mitochondrial Ca
+
mellitus reduces the function and expression of ATP⁃de⁃ ⁃activated K channels in cardiac myocytes：a mechanism
pendent K（+）channels in cardiac mitochondria［J］. Life of the cardioprotective effect and modulation by protein
Sci，2013，92（11）：664-668 kinase A［J］. Circulation，2005，111（2）：198-203
2+
［87］ LU T，YE D，HE T，et al. Impaired Ca ⁃dependent activa⁃ ［100］FUKASAWA M，NISHIDA H，SATO T，et al. 6⁃［4⁃（1⁃Cy⁃
+
2 +
tion of large⁃conductance Ca ⁃activated K channels in clohexyl⁃1H⁃tetrazol⁃5⁃yl）butoxy］⁃3，4⁃dihydro⁃2⁃（1H）
the coronary artery smooth muscle cells of Zucker diabet⁃ quinolinone（cilostazol），a phosphodiesterase type 3 in⁃
ic fatty rats［J］. Biophys J，2008，95（11）：5165-5177 hibitor，reduces infarct size via activation of mitochondri⁃
+
2+
［88］ LESNEFSKY E J，CHEN Q，TANDLER B，et al. Mito⁃ al Ca ⁃activated K channels in rabbit hearts［J］. J Phar⁃
chondrial dysfunction and myocardial ischemia ⁃ reperfu⁃ macol Exp Ther，2008，326（1）：100-104
sion：implications for novel therapies［J］. Annu Rev Phar⁃ ［101］XU Y，TUTEJA D，ZHANG Z，et al. Molecular identifica⁃
2+ +
macol Toxicol，2017，57：535-565 tion and functional roles of a Ca ⁃activated K channel in
［89］ MORCIANO G，GIORGI C，BONORA M，et al. Molecular human and mouse hearts［J］. J Biol Chem，2003，278
identity of the mitochondrial permeability transition pore （49）：49085-49094
2 +
and its role in ischemia⁃reperfusion injury［J］. J Mol Cell ［102］WANG X，YIN C，XI L，et al. Opening of Ca ⁃activated
+
Cardiol，2015，78：142-153 K channels triggers early and delayed preconditioning
［90］ PIOT C，CROISILLE P，STAAT P，et al. Effect of cyclo⁃ against I/R injury independent of NOS in mice［J］. Am J
sporine on reperfusion injury in acute myocardial infarc⁃ Physiol Heart Circ Physiol，2004，287（5）：2070-2077
tion［J］. N Engl J Med，2008，359（5）：473-481 ［103］BENTZEN B H ，NARDI A，CALLOE K，et al. The small
［91］ CUNG TT，MOREL O，CAYLA G，et al. Cyclosporine be⁃ molecule NS11021 is a potent and specific activator of
+
2+
fore PCI in patients with acute myocardial infarction［J］. Ca ⁃activated big⁃conductance K channels［J］. Mol Phar⁃
N Engl J Med，2015，373（11）：1021-1031 macol，2007，72（4）：1033-1044
［92］ HUO J，LU S，KWONG J Q，et al. MCUb induction pro⁃ ［104］AON M A，CORTASSA S，WEI A C，et al. Energetic per⁃
+
tects the heart from postischemic remodeling［J］. Circ formance is improved by specific activation of K fluxes
Res，2020，127（3）：379-390 through K（Ca）channels in heart mitochondria［J］. Bio⁃
［93］ LAMBERT J P，LUONGO T S，TOMAR D，et al. MCUB chim Biophys Acta，2010，1797（1）：71-80