Page 153 - 南京医科大学学报自然科学版

第42卷第9期 魏 越，刘 阳，鲁 明. 脂质成分在帕金森病发生中的研究进展［J］.
2022年9月 南京医科大学学报（自然科学版），2022，42（09）：1341-1348 ·1347 ·

633-645 phys Acta，2015，1853：361-369
［15］ MAULIK M，MITRA S，BASMAYOR A M，et al. Genetic ［26］ FANG F，ZHAN Y，HAMMAR N，et al. Lipids，apolipo⁃
silencing of fatty acid desaturases modulates α⁃synuclein proteins，and the risk of Parkinson disease［J］. Circ Res，
toxicity and neuronal loss inparkinson⁃like models of C. 2019，125（6）：643-652
elegans［J］. Front Aging Neurosci，2019，11：207 ［27］ XICOY H，KLEMANN C J，DE WITTE W，et al. Shared
［16］ SHARON R，GOLDBER M S，BAR ⁃ JOSEF I，et al. α ⁃ genetic etiology between Parkinson’s disease and blood
Synuclein occurs in lipid⁃rich high molecular weight com⁃ levels of specific lipids［J］. NPJ Parkinsons Dis，2021，7
plexes，binds fatty acids，and shows homology to the fatty （1）：23
ˇ
·
acid⁃binding proteins［J］. Proc Natl Acad Sci USA，2001， ［28］ SCANSIZ D，ÜNALI，ÜSTÜNDAG Ü V，et al. Caprylic acid
98：9110-9115 ameliorates rotenone induced inflammation and oxidative
［17］ FECCHIO C，PALAZZI L，DE LAURETO P P. α⁃Synuclein stress in the gut⁃brain axis in Zebrafish［J］. Mol Biol Rep，
and polyunsaturated fatty acids：molecular basis of the in⁃ 2021，48（6）：5259-5273
teraction and implication in neurodegeneration［J］. Mole⁃ ［29］ FANNING S，HAQUE A，IMBERDIS T，et al. Lipidomic
cules，2018，23：1531 analysis of α ⁃ synuclein neurotoxicity Identifies stearoyl
［18］ LAMONTAGNE⁃PROULX J，COULOMBE K，DAHHANI coa desaturase as a target for parkinson treatment［J］.Mol
F，et al. Effect of docosahexaenoic acid（DHA）at the en⁃ Cell，2019，73（5）：1001-1014
teric level in a synucleinopathy mouse model［J］. Nutri⁃ ［30］ MORRIS G，MAES M，BERK M，et al. Nutritional ketosis
ents，2021，13（12）：4218 as an intervention to relieve astrogliosis：Possible thera⁃
［19］ BARROS A S，CRISPIM R Y G，CAVALCANTI J U，et peutic applications in the treatment of neurodegenerative
al. Impact of the chronic omega⁃3 fatty acids supplementa⁃ and neuroprogressive disorders［J］. Eur Psychiatry，2020，
tion in hemiparkinsonismmodelinduced by 6⁃Hydroxydo⁃ 63（1）：1-21
pamine in rats［J］. Basic Clin Pharmacol Toxicol，2017， ［31］ MUSILLE P M，KOHN J A，ORTLUND E A. Phospholipid⁃
120（6）：523-531 driven gene regulation［J］. FEBS Lett，2013，587：1238-
［20］ DELATTRE A M，CARABELLI B，MORI M A，et al. Ma⁃ 1246
ternal omega ⁃ 3 supplement improves dopaminergic sys⁃ ［32］ JIANG Z，HESS S K，HEINRICH F，et al. Molecular de⁃
tem in pre⁃ and postnatal inflammation⁃induced neurotox⁃ tails of α ⁃ Synuclein membrane association revealed by
icity in Parkinson’s disease model［J］. Neurobiol，2017， neutrons and photons［J］. PhysChemB，2015，119：4812-
54：2090-2106 4823
［21］ SHAMOTO⁃NAGAI M，HISAKA S，NAOI M，et al. Modi⁃ ［33］ MIZUNO S，SASAI H，KUME A，et al. Dioleoyl⁃phospha⁃
fication of α⁃synuclein by lipid peroxidation products de⁃ tidic acid selectively binds to α⁃synuclein and strongly in⁃
rived from polyunsaturated fatty acids promotes toxic duces its aggregation［J］. FEBS Lett，2017，591（5）：784-791
oligomerization：its relevance to Parkinson disease［J］. ［34］ SEYFRIED T N，CHOI H，CHEVALIER A，et al. Sex⁃re⁃
Clin Biochem Nutr，2018，62：207-212 lated abnormalities in substantia nigralipids in Parkinson’
［22］ DENG H，LI W. Monoacylglycerol lipase inhibitors：modu⁃ s disease［J］. ASN Neuro，2018，10：1-10
lators for lipid metabolism in cancer malignancy，neuro⁃ ［35］ WANG S，ZHANG S，XU C，et al. Chemical compensation
logical and metabolic disorders［J］. Acta Pharm Sin B， of mitochondrial phospholipid depletion in yeast and ani⁃
2020，10（4）：582-602 mal models of parkinson’s Disease［J］. PLoS One，2016，
［23］ NAVARRETE F，GARCIA⁃GUTIERREZ M S，ARACIL⁃ 11（10）：1-21
FERNANDEZ A，et al. Cannabinoid CB1 and CB2 Recep⁃ ［36］ KAY J G，GRINSTEIN S. Phosphatidylserine ⁃ mediated
tors，and monoacylglycerol lipase gene expression altera⁃ cellularsignaling［J］. Adv Exp Med Biol，2013，991：177-193
tions in the basal ganglia of patients with Parkinson’s Dis⁃ ［37］ BUTLER C A，POPESCU A S，KITCHENER E J A，et al.
ease［J］. Neurotherapeutics，2018，15（2）：459-469 Microglial phagocytosis of neurons in neurodegeneration，
［24］ WOOD P L，TIPPIREDDY S，FERIANTE J，et al. Aug⁃ and its regulation［J］. J Neurochem，2021，158（3）：621-639
mented frontal cortex diacylglycerol levels in Parkinson’s ［38］ ALMANDOZ⁃GIL L，LINDSTROM V，SIGVARDSON J，
disease and Lewy body disease［J］. PLoS One，2018，13 et al. Mapping of surface⁃exposed epitopes of in vitro and
（3）：1-15 in vivo aggregated species of alpha ⁃ synuclein［J］. Cell
［25］ TSUCHIYA R，TANAKA T，HOZUMI Y，et al. Downregu⁃ Mol Neurobiol，2017，37（7）：1217-1226
lation of diacylglycerol kinase ζ enhances activation of cy⁃ ［39］ LOU X，KIM J，HAWK B J，et al. α⁃Synuclein may cross⁃
tokine⁃induced NF⁃κB signaling pathway［J］. BiochimBio⁃ bridge v ⁃ SNARE and acidic phospholipids to facilitate