Page 67 - 南京医科大学自然版

第44卷第10期 南京医科大学学报（自然科学版）
2024年10月 Journal of Nanjing Medical University（Natural Sciences） ·1383 ·

·临床研究·

中性粒细胞/淋巴细胞比值在肺炎支原体肺炎预后中的预测价

值研究

蒋亚洲 ，刘 峰 1*
1，2
南京医科大学附属儿童医院呼吸科，江苏 南京 210008；徐州医科大学附属宿迁医院儿科，江苏 宿迁 223800
1 2

［摘 要］ 目的：探索中性粒细胞/淋巴细胞比值（neutrophil to lymphocyte ratio，NLR）在肺炎支原体肺炎（Mycoplasma pneu⁃
moniae pneumonia，MPP）预后中的评估价值。方法：纳入 2019 年 1 月—2023 年 12 月在徐州医科大学附属宿迁医院住院的
2 375例MPP患儿。根据病情将患儿分成重症肺炎支原体肺炎（severe Mycoplasma pneumoniae pneumonia，SMPP）组（n=125）和
非 SMPP 组（n=2 250）以及难治性肺炎支原体肺炎（refractory Mycoplasma pneumoniae pneumonia，RMPP）组（n=451）和非 RMPP
组（n=1 924）。收集患儿基本资料及临床信息，回顾性分析 NLR 在 SMPP 及 RMPP 预后中评估价值。结果：NLR 是独立预测
SMPP 的指标（OR=1.188，95%CI：1.123~1.299，P=0.033）。与低 NLR 组相比，高 NLR 组 SMPP 发生率更高（P < 0.001）。NLR 也
是独立预测RMPP的指标（OR=1.320，95%CI：1.145~1.432，P < 0.001）。高NLR组的SMPP发生率、RMPP发生率、ICU住院发生
率、总发热时间、住院天数以及住院费用高于低NLR 组（P < 0.001）。结论：NLR 可独立预测MPP患儿预后，为SMPP及RMPP
的早期诊疗提供指导。
［关键词］ 中性粒细胞/淋巴细胞比值；肺炎支原体肺炎；重症肺炎支原体肺炎；难治性肺炎支原体肺炎；预后
［中图分类号］ R563.15 ［文献标志码］ A ［文章编号］ 1007⁃4368（2024）10⁃1383⁃07
doi：10.7655/NYDXBNSN240506

The predictive value of neutrophil to lymphocyte ratio in the prognosis of Mycoplasma
pneumoniae pneumonia
1，2
JIANG Yazhou ，LIU Feng 1*
Department of Respiration，Children’s Hospital of Nanjing Medical University，Nanjing 210008；Department of
1 2
Pediatrics，Suqian Hospital Affiliated to Xuzhou Medical University，Suqian 223800，China

［Abstract］ Objective： To explore the evaluation value of neutrophil to lymphocyte ratio（NLR）in the prognosis of Mycoplasma
pneumoniae pneumonia（MPP）. Methods：A retrospective analysis was applied to 2 375 hospitalized children with MPP in Suqian
Hospital Affiliated to Xuzhou Medical University from January 2019 to December 2023. According to the severity of the condition，the
children were divided into severe MPP（SMPP）group（n=125）and non⁃SMPP group（n=2 250），or into refractory MPP（RMPP）group
（n=451）and non⁃RMPP group（n=1 924）. The basic information and clinical data of all pediatric patients were collected to assess the
prognostic value of NLR in SMPP and RMPP. Results：NLR was an independent predictor of SMPP（OR=1.188，95% CI：1.123-1.299，
P=0.033）. Compared with children with a low NLR，children with a high NLR had a higher incidence of SMPP（P < 0.001）. NLR was
also an independent predictor of RMPP（OR=1.320，95%CI：1.145-1.432，P < 0.001）. Children with a high NLR were more likely to
develop SMPP and RMPP as well as had higher ICU hospitalization rate，total fever duration，longer hospital stays，and higher
hospitalization costs，compared those with a low NLR（P < 0.001）. Conclusion：NLR may be used to independently predict the
prognosis of MPP and provide guidance for early treatment of SMPP and RMPP.
［Key words］ neutrophil to lymphocyte ratio；Mycoplasma pneumoniae pneumonia；severe Mycoplasma pneumoniae pneumonia；
refractory Mycoplasma pneumoniae pneumonia；prognosis
［J Nanjing Med Univ，2024，44（10）：1383⁃1389］

［基金项目］ 国家自然科学基金（82270008）；宿迁市科技局科技计划项目（K202118）
∗
通信作者（Corresponding author），E⁃mail： axsliu@163.com