Page 138 - 南京医科大学学报自然科学版
P. 138
第42卷第6期
·890 · 南 京 医 科 大 学 学 报 2022年6月
cin⁃induced cell apoptosis in pancreatic cancer by inhibit⁃ [31] ZHANG Y,XIE C,WANG H,et al. Irisin exerts dual
ing the PI3K/AKT/NF⁃ κB pathway[J]. Med Sci Monit, effects on browning and adipogenesis of human white adi⁃
2019,25:6085-6096 pocytes[J]. Am J Physiol Endocrinol Metab,2016,311
[18] DIMITRIADIS G,MARATOU E,KOUNTOURI A,et al. (2):E530-541
Regulation of postabsorptive and postprandial glucose me⁃ [32] LI H,ZHANG Y,WANG F,et al. Effects of irisin on the
tabolism by insulin ⁃ dependent and insulin ⁃ independent differentiation and browning of human visceral white adi⁃
mechanisms:an integrative approach [J]. Nutrients, pocytes[J]. Am J Transl Res,2019,11(12):7410-7421
2021,13(1):159 [33] TSAI Y C,WANG C W,WEN B Y,et al. Involvement of
[19] EDGERTON D S,MOORE M C,GREGORY J M,et al. the p62/Nrf2/HO⁃1 pathway in the browning effect of
Importance of the route of insulin delivery to its control of irisin in 3T3 ⁃ L1 adipocytes[J]. Mol Cell Endocrinol,
glucose metabolism[J]. Am J Physiol Endocrinol Metab, 2020,514:110915
2021,320(5):E891-E897 [34] LIU T Y,SHI C X,GAO R,et al. Irisin inhibits hepatic
[20] HAN H S,KANG G,KIM J S,et al. Regulation of glucose gluconeogenesis and increases glycogen synthesis via the
metabolism from a liver⁃centric perspective[J]. Exp Mol PI3K/Akt pathway in type 2 diabetic mice and hepatocytes
Med,2016,48:e218 [J]. Clin Sci(Lond),2015,129(10):839-850
[21] TUPS A,BENZLER J,SERGI D,et al. Central regulation [35] MO L,SHEN J,LIU Q,et al. Irisin is regulated by CAR
of glucose homeostasis[J]. Compr Physiol,2017,7(2): in liver and is a mediator of hepatic glucose and lipid me⁃
741-764 tabolism[J]. Mol Endocrinol,2016,30(5):533-542
[22] PANG Y,ZHU H,XU J,et al. β⁃arrestin⁃2 is involved in [36] CHOE S S,CHOI A H,LEE J W,et al. Chronic activation
irisin induced glucose metabolism in type 2 diabetes via of liver X receptor induces beta⁃cell apoptosis through hy⁃
p38 MAPK signaling[J]. Exp Cell Res,2017,360(2): peractivation of lipogenesis:liver X receptor⁃mediated li⁃
199-204 potoxicity in pancreatic beta⁃cells[J]. Diabetes,2007,56
[23] NATALICCHIO A,MARRANO N,BIONDI G,et al. The (6):1534-1543
+
myokine irisin is released in response to saturated fatty [37] LI D J,SUN S J,FU J T,et al. NAD ⁃boosting therapy
acids and promotes pancreatic β⁃cell survival and insulin alleviates nonalcoholic fatty liver disease via stimulating
secretion[J]. Diabetes,2017,66(11):2849-2856 a novel exerkine Fndc5/irisin[J]. Theranostics,2021,11
[24] HOLLOSZY J O. Regulation of mitochondrial biogenesis (9):4381-4402
and GLUT4 expression by exercise[J]. Compr Physiol, [38] LIU T Y,XIONG X Q,REN X S,et al. FNDC5 alleviates
2011,1(2):921-940 hepatosteatosis by restoring AMPK/mTOR ⁃ mediated au⁃
[25] HUH J Y,MOUGIOS V,KABASAKALIS A,et al. Exer⁃ tophagy,fatty acid oxidation,and lipogenesis in mice[J].
cise⁃induced irisin secretion is independent of age or fit⁃ Diabetes,2016,65(11):3262-3275
ness level and increased irisin may directly modulate mus⁃ [39] SO W Y,LEUNG P S. Irisin ameliorates hepatic glucose/
cle metabolism through AMPK activation[J]. J Clin Endo⁃ lipid metabolism and enhances cell survival in insulin⁃re⁃
crinol Metab,2014,99(11):E2154-E2161 sistant human HepG2 cells through adenosine monophos⁃
[26] YE X,SHEN Y,NI C,et al. Irisin reverses insulin resis⁃ phate ⁃ activated protein kinase signaling[J]. Int J Bio⁃
tance in C2C12 cells via the p38⁃MAPK⁃PGC⁃1α pathway chem Cell Biol,2016,78:237-247
[J]. Peptides,2019,119:170120 [40] TANG H,YU R,LIU S,et al. Irisin inhibits hepatic cho⁃
[27] KIM N,LEE J O,LEE H J,et al. AMPK,a metabolic sen⁃ lesterol synthesis via AMPK⁃SREBP2 signaling[J]. EBio⁃
sor,is involved in isoeugenol⁃induced glucose uptake in Medicine,2016,6:139-148
muscle cells[J]. J Endocrinol,2016,228(2):105-114 [41] ZHANG D,XIE T,LEUNG P S. Irisin ameliorates glucoli⁃
[28] LEEH J,LEEJO,KIM N,et al. Irisin,a novel myokine,regu⁃ potoxicity⁃associated β⁃cell dysfunction and apoptosis via
lates glucose uptake in skeletal muscle cells via AMPK AMPK signaling and anti⁃inflammatory actions[J]. Cell
[J]. Mol Endocrinol,2015,29(6):873-881 Physiol Biochem,2018,51(2):924-937
[29] HANKIR M,KLINGENSPOR M. Brown adipocyte glu⁃ [42] LI D J,HUANG F,LU W J,et al. Metformin promotes iri⁃
cose metabolism:a heated subject[J]. EMBO Rep,2018, sin release from murine skeletal muscle independently of
19(9):e46404 AMP⁃activated protein kinase activation[J]. Acta Physiol
[30] 刘碧莲,刘 峰. 白色脂肪米色化及其在代谢平衡中的 (Oxf),2015,213(3):711-721
调控作用[J]. 南京医科大学学报(自然科学版),2016, [收稿日期] 2021-11-17
36(1):8-11 (本文编辑:陈汐敏)

