Page 119 - 南京医科大学学报自然科学版

第44卷第1期 李 磊，孙秀兰. 代谢重编程对小胶质细胞功能的调节作用［J］.
2024年1月 南京医科大学学报（自然科学版），2024，44（01）：105-114 ·113 ·

RODRÍGUEZ F，et al. Brain lipidomics as a rising field from mechanisms to translation［J］. Nat Med，2011，17
in neurodegenerative contexts：perspectives with machine （7）：796-808
learning approaches［J］. Front Neuroendocrinol，2021， ［59］ GIMENO⁃BAYÓN J，LÓPEZ⁃LÓPEZ A，RODRÍGUEZ M
61：100899 J，et al. Glucose pathways adaptation supports acquisition
［45］ GAO Y Q，VIDAL⁃ITRIAGO A，KALSBEEK M，et al. Li⁃ of activated microglia phenotype［J］. J Neurosci Res，
poprotein lipase maintains microglial innate immunity in 2014，92（6）：723-731
obesity［J］. Cell Rep，2017，20（13）：3034-3042 ［60］ LAURO C，CHECE G，MONACO L，et al. Fractalkine
［46］ ZHOU X，ZHAO R，LV M F，et al. ACSL4 promotes mi⁃ modulates microglia metabolism in brain ischemia［J］.
croglia ⁃ mediated neuroinflammation by regulating lipid Front Cell Neurosci，2019，13：414
metabolism and VGLL4 expression［J］. Brain Behav Im⁃ ［61］ REN Z，CHEN L，WANG Y，et al. Activation of the Ome⁃
mun，2023，109：331-343 ga⁃3 fatty acid receptor GPR120 protects against focal ce⁃
［47］ NADJAR A. Role of metabolic programming in the modu⁃ rebral ischemic injury by preventing inflammation and
lation of microglia phagocytosis by lipids［J］. Prostaglan⁃ apoptosis in mice［J］. J Immunol，2019，202（3）：747-759
dins Leukot Essent Fat Acids，2018，135：63-73 ［62］ LIAO B Y，GENG L L，ZHANG F，et al. Adipocyte fatty
［48］ CHEN S，ZHANG H Y，PU H J，et al. N⁃3 PUFA supple⁃ acid⁃binding protein exacerbates cerebral ischaemia inju⁃
mentation benefits microglial responses to myelin patholo⁃ ry by disrupting the blood⁃brain barrier［J］. Eur Heart J，
gy［J］. Sci Rep，2014，4：7458 2020，41（33）：3169-3180
［49］ NAKAJIMA K，KANAMATSU T，TAKEZAWA Y，et al. Up⁃ ［63］ SONG S S，YU L，HASAN M N，et al. Elevated microglial
regulation of glutamine synthesis in microglia activated oxidative phosphorylation and phagocytosis stimulate post⁃
with endotoxin［J］. Neurosci Lett，2015，591：99-104 stroke brain remodeling and cognitive function recovery
［50］ LANGE R A，CIGARROA R G，WELLS P J，et al. in mice［J］. Commun Biol，2022，5（1）：35
Influence of anterograde flow in the infarct artery on the ［64］ SCHELTENS P，BLENNOW K，BRETELER K，et al. Al⁃
incidence of late potentials after acute myocardial infarc⁃ zheimer’s disease［J］. Lancet，2016，388（10043）：505-
tion［J］. Am J Cardiol，1990，65（9）：554-558 517
［51］ JHA A K，HUANG S C C，SERGUSHICHEV A，et al. Net⁃ ［65］ CAI Y L，LIU J L，WANG B，et al. Microglia in the neuro⁃
work integration of parallel metabolic and transcriptional inflammatory pathogenesis of Alzheimer’s disease and
data reveals metabolic modules that regulate macrophage related therapeutic targets［J］. Front Immunol，2022，13：
polarization［J］. Immunity，2015，42（3）：419-430 856376
［52］ CALABRESE C，POPPLETON H，KOCAK M，et al. A ［66］ MATTSON M P，ARUMUGAM T V. Hallmarks of brain
perivascular niche for brain tumor stem cells［J］. Cancer aging：adaptive and pathological modification by metabolic
Cell，2007，11（1）：69-82 states［J］. Cell Metab，2018，27（6）：1176-1199
［53］ LI L，CHENG S Q，YU J B，et al. Resolvin D1 reprograms ［67］ BAIK S H，KANG S，LEE W，et al. A breakdown in meta⁃
energy metabolism to promote microglia to phagocytize bolic reprogramming causes microglia dysfunction in Al⁃
neutrophils after ischemic stroke［J］. Cell Rep，2023，42 zheimer’s disease［J］. Cell Metab，2019，30（3）：493-507
（6）：112617 ［68］ MCINTOSH A，MELA V，HARTY C，et al. Iron accumula⁃
［54］ WU S M，WU B，LIU M，et al. Stroke in China：advances tion in microglia triggers a cascade of events that leads to
and challenges in epidemiology，prevention，and manage⁃ altered metabolism and compromised function in APP/
ment［J］. Lancet Neurol，2019，18（4）：394-405 PS1 mice［J］. Brain Pathol Zurich Switz，2019，29（5）：
［55］ MOSCONI M G，PACIARONI M. Treatments in ischemic 606-621
stroke：current and future［J］. Eur Neurol，2022，85（5）： ［69］ LU J，ZHOU W，DOU F F，et al. TRPV1 sustains microglial
349-366 metabolic reprogramming in Alzheimer’s disease［J］.
［56］ HU X M，LEAK R K，SHI Y J，et al. Microglial and mac⁃ EMBO Rep，2021，22（6）：e52013
rophage polarization ⁃ new prospects for brain repair［J］. ［70］ LAMBERT J C，IBRAHIM⁃VERBAAS C A，HAROLD D，
Nat Rev Neurol，2015，11（1）：56-64 et al. Meta⁃analysis of 74，046 individuals identifies 11
［57］ GAIRE B P. Microglia as the critical regulators of neuro⁃ new susceptibility loci for Alzheimer’s disease［J］. Nat
protection and functional recovery in cerebral ischemia Genet，2013，45（12）：1452-1458
［J］. Cell Mol Neurobiol，2022，42（8）：2505-2525 ［71］ YEH F L，WANG Y Y，TOM I，et al. TREM2 binds to apo⁃
［58］ IADECOLA C，ANRATHER J. The immunology of stroke： lipoproteins，including APOE and CLU/APOJ，and there⁃