Page 157 - 南京医科大学自然版
P. 157

第44卷第12期                崔代迅,杨小慧,冯振卿. 呼吸道合胞病毒疫苗及中和抗体研究进展[J].
                 2024年12月                    南京医科大学学报(自然科学版),2024,44(12):1763-1772                      ·1771 ·


                    syncytial virus infection occurring after receipt of live,  trial[J]. Lancet Respir Med,2021,9(10):1111-1120
                    attenuated,respiratory syncytial virus vaccines[J]. Vac⁃  [54]A phase Ⅲ double⁃blind study to assess safety and effica⁃
                    cine,2007,25(42):7372-7378                         cy of an RSV maternal unadjuvanted vaccine,in pregnant
               [43]KARRON R A,LUONGO C,THUMAR B,et al. A gene          women and infants born to vaccinated mothers[EB/OL].
                    deletion that up⁃regulates viral gene expression yields an  (2020⁃11⁃20)[2022⁃4⁃12]. https://clinicaltrials. gov/ct2/
                    attenuated RSV vaccine with improved antibody responses  show/NCT04605159
                    in children[J]. Sci Transl Med,2015,7(312):312ra175  [55]PAPI A,ISON M G,LANGLEY J M,et al. Respiratory
               [44]MCFARLAND E J,KARRON R A,MURESAN P,et al.           syncytial virus prefusion F protein vaccine in older
                    Live⁃attenuated respiratory syncytial virus vaccine candi⁃  adults[J]. N Engl J Med,2023,388(7):595-608
                    date with deletion of RNA synthesis regulatory protein M2  [56]GUIÑAZÚ J R,TICA J,ANDREWS C P,et al. 121. A re⁃
                    ⁃ 2 is highly immunogenic in children[J]. J Infect Dis,  spiratory syncytial virus prefusion F protein(RSVPreF3)
                    2018,217(9):1347-1355                              candidate vaccine administered in older adults in a phase
               [45]BUCHHOLZ U J,CUNNINGHAM C K,MURESAN P,et            Ⅰ/Ⅱ randomized clinical trial is immunogenic[J]. Open
                    al. Live respiratory syncytial virus(RSV)vaccine candi⁃  Forum Infect Dis,2020,7(Supple 1):S188-S189
                    date containing stabilized temperature ⁃ sensitivity muta⁃  [57]GSK presents positive clinical data on maternal and older
                    tions is highly attenuated in RSV⁃seronegative infants and  adults RSV candidate vaccines[EB/OL].(2020⁃10⁃21)
                    children[J]. J Infect Dis,2018,217(9):1338-1346   [2022⁃04⁃12]. https://www. gsk. com/en⁃gb/media/press⁃
               [46]MCFARLAND E J,KARRON R A,MURESAN P,et al.           releases/gsk⁃presents⁃positive⁃clinical⁃data⁃on⁃maternal⁃
                    Live ⁃ attenuated respiratory syncytial virus vaccine with  and⁃older⁃adults⁃rsv⁃candidate⁃vaccines
                    M2⁃2 deletion and with small hydrophobic noncoding re⁃  [58]FELDMAN R G,ANTONELLI⁃INCALZI R,STEENACK⁃
                    gion is highly immunogenic in children[J]. J Infect Dis,  ERS K,et al. Respiratory syncytial virus prefusion F pro⁃
                    2020,221(12):2050-2059                             tein vaccine is efficacious in older adults with underlying
               [47]ROE M K,PEREZ M A,HSIAO H M,et al. An RSV live⁃     medical conditions[J]. Clin Infect Dis,2024,78(1):
                    Attenuated vaccine candidate lacking G protein mucin do⁃  202-209
                    mains is attenuated,immunogenic,and effective in pre⁃  [59]A study of a RSV vaccine when given together with TDap
                    venting RSV in BALB/c mice[J]. J Infect Dis,2022,227  in healthy nonpregnant women aged between 18 to 49
                   (1):50-60                                           years[EB/OL].(2019⁃08⁃26)[2022⁃04⁃12]. https://clini⁃
               [48]TOPALIDOU X,KALERGIS A M,PAPAZISIS G. Respi⁃        caltrials. gov/ct2/show/NCT04071158
                    ratory syncytial virus vaccines:a review of the candidates  [60]WALSH E E,PÉREZ MARC G,ZAREBA A M,et al. Ef⁃
                    and the approved vaccines[J]. Pathogens,2023,12(10):  ficacy and safety of a bivalent RSV prefusion F vaccine in
                    1259                                               older adults[J]. N Engl J Med,2023,388(16):1465-1477
               [49]KARRON R A,LUONGO C,MATEO J S,et al. Safety   [61]Safety and efficacy of ARS13 in the elderly[EB/OL].
                    and immunogenicity of the respiratory syncytial virus vac⁃  (2020⁃12⁃23)[2022⁃04⁃12]. https://clinicaltrials. gov/
                    cine RSV/ΔNS2/Δ1313/I1314L in RSV⁃seronegative chil⁃  ct2/show/NCT04681833
                    dren[J]. J Infect Dis,2020,222(1):82-91      [62]TORREY H L,KALIAPERUMAL V,BRAMHECHA Y,
               [50]MALKIN E,YOGEV R,ABUGHALI N,et al. Safety and       et al. Evaluation of the protective potential of antibody
                    immunogenicity of a live attenuated RSV vaccine in healthy  and T cell responses elicited by a novel preventative vac⁃
                    RSV ⁃ seronegative children 5 to 24 months of age[J].  cine towards respiratory syncytial virus small hydrophobic
                    PLoS One,2013,8(10):e77104                         protein[J]. Hum Vaccin Immunother,2020,16(9):
               [51]CHIRKOVA T,HA B,RIMAWI B H,et al. In vitro model    2007-2017
                    for the assessment of human immune responses to subunit  [63]Study of VN⁃0200 in apanese healthy adults and elderly
                    RSV vaccines[J]. PLoS One,2020,15(3):e0229660      subjects[EB/OL].(2021⁃06⁃04)[2022⁃04⁃12]. https://
               [52]CRANK M C,RUCKWARDT T J,CHEN M,et al. A proof       clinicaltrials. gov/ct2/show/NCT04914520
                    of concept for structure ⁃ based vaccine design targeting  [64]FALSEY A R,WILLIAMS K,GYMNOPOULOU E,et al.
                    RSV in humans[J]. Science,2019,365(6452):505-509   Efficacy and safety of an Ad26. RSV. preF⁃RSV preF pro⁃
               [53]RUCKWARDT T J,MORABITO K M,PHUNG E,et al.           tein vaccine in older adults[J]. N Engl J Med,2023,388
                    Safety,tolerability,and immunogenicity of the respiratory  (7):609-620
                    syncytial virus prefusion F subunit vaccine DS ⁃ Cav1:a  [65]GROOTHUIS J R,SIMOES E A,LEVIN M J,et al. Pro⁃
                    phase 1,randomised,open⁃label,dose⁃escalation clinical  phylactic administration of respiratory syncytial virus im⁃
   152   153   154   155   156   157   158   159   160   161   162