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[21]CHERRY E M,ABBOTT D,AMAYA M,et al. Venetoclax [33]CORTES J E,TALLMAN M S,SCHILLER G J,et al.
and azacitidine compared with induction chemotherapy Phase 2b study of 2 dosing regimens of quizartinib mono⁃
for newly diagnosed patients with acute myeloid leuke⁃ therapy in FLT3 ⁃ ITD ⁃ mutated,relapsed or refractory
mia[J]. Blood Adv,2021,5(24):5565-5573 AML[J]. Blood,2018,132(6):598-607
[22]TARLOCK K,LAMBLE A J,WANG Y C,et al. CEBPA⁃ [34]CORTES J E,KHALED S,MARTINELLI G,et al. Quizar⁃
bZip mutations are associated with favorable prognosis in tinib versus salvage chemotherapy in relapsed or refractory
de novo AML:a report from the Children’s Oncology FLT3 ⁃ ITD acute myeloid leukaemia(QuANTUM ⁃ R):a
Group[J]. Blood,2021,138(13):1137-1147 multicentre,randomised,controlled,open⁃label,phase 3
[23] TAUBE F,GEORGI J A,KRAMER M,et al. CEBPA trial[J]. Lancet Oncol,2019,20(7):984-997
mutations in 4708 patients with acute myeloid leukemia: [35]CORTES J,PERL A E,DÖHNER H,et al. Quizartinib,
differential impact of bZIP and TAD mutations on out⁃ an FLT3 inhibitor,as monotherapy in patients with relapsed
come[J]. Blood,2022,139(1):87-103 or refractory acute myeloid leukaemia:an open ⁃ label,
[24]WAKITA S,SAKAGUCHI M,OH I,et al. Prognostic im⁃ multicentre,single⁃arm,phase 2 trial[J]. Lancet Oncol,
pact of CEBPA bZIP domain mutation in acute myeloid 2018,19(7):889-903
leukemia[J]. Blood Adv,2022,6(1):238-247 [36]WANG E S,GOLDBERG A D,WALTER R B,et al. Long⁃
[25]AWADA H,DURMAZ A,GURNARI C,et al.Machine term results of a phase 2 trial of crenolanib combined with
learning integrates genomic signatures for subclassifica⁃ 7+3 chemotherapy in adults with newly diagnosed FLT3
tion beyond primary and secondary acute myeloid leuke⁃ mutant AML[J]. J Clinic Oncol,2022,40(16):7007
mia[J]. Blood,2021,138(19):1885-1895 [37]SALLMAN D A,DEZERN A E,GARCIA⁃MANERO G,
[26]BERNARD E,TUECHLER H,GREENBERG P L,et al. et al. Eprenetapopt(APR⁃246)and azacitidine in TP53⁃
Molecular international prognostic scoring system for my⁃ mutant myelodysplastic syndromes[J]. J Clin Oncol,
elodys ⁃ plastic syndromes[J]. NEJM Evidence,2022,1 2021,39(14):1584-1594
(7):2200008 [38]CLUZEAU T,SEBERT M,RAHMÉ R,et al. Epreneta⁃
[27]CARAVELLA J A,LIN J,DIEBOLD R B,et al. Structure⁃ popt plus azacitidine in TP53 ⁃ mutated myelodysplastic
based design and identification of FT ⁃ 2102(Olutas⁃ syndromes and acute myeloid leukemia:a phase Ⅱ study
idenib),a potent mutant⁃selective IDH1 inhibitor[J]. J by the groupe francophone des myélodysplasies(GFM)[J].
Med Chem,2020,63(4):1612-1623 J Clin Oncol,2021,39(14):1575-1583
[28]CORTES J E,FENAUX P,YEE K,et al. Oluta⁃sidenib [39]MISHRA A,TAMARI R,DEZERN A E,et al. Epreneta⁃
(FT⁃2102)induces durable complete remissions in patients popt plus azacitidine after allogeneic hematopoietic stem⁃
with relapsed/refractory mIDH1 acute myeloid leukemia. cell transplantation for TP53⁃mutant acute myeloid leuke⁃
Results from a planned interim analysis of a phase 2 piv⁃ mia and myelodysplastic syndromes[J]. J Clin Oncol,
otal clinical trial[J].Blood,2022,140(1):6193-6196 2022,40(34):3985-3993
[29]LACHOWIEZ C A,GARCIA J S,BORTHAKUR G,et al. [40]ISSA G C,ALDOSS I,DIPERSIO J F,et al. The menin in⁃
A phase Ⅰb/Ⅱ study of ivosidenib with venetoclax +/- hibitor SNDX⁃5613(revumenib)leads to durable respons⁃
azacitidine in IDH1⁃mutated hematologic malignancies[J]. es in patients(Pts)with KMT2A⁃rearranged or NPM1 mu⁃
J Clinic Oncol,2022,40(16):7018 tant AML:updated results of a phase(Ph)1 study[J].
[30]DÖHNER H,WEBER D,KRZYKALLA J,et al. Midostau⁃ Blood,2022,140(1):150-152
rin plus intensive chemotherapy for younger and older pa⁃ [41]ERBA H P,FATHI A T,ISSA G C,et al. Update on a
tients with AML and FLT3 internal tandem duplications[J]. phase 1/2 first ⁃ in ⁃ human study of the menin ⁃ KMT2A
Blood Adv,2022,6(18):5345-5355 (MLL)inhibitor ziftomenib(KO⁃539)in patients with re⁃
[31]DÖHNER K,THIEDE C,JAHN N,et al. Impact of NPM1/ lapsed or refractory acute myeloid leukemia[J]. Blood,
FLT3⁃ITD genotypes defined by the 2017 European Leu⁃ 2022,140(1):153-156
kemiaNet in patients with acute myeloid leukemia[J]. [42]ISSA G C,CUGLIEVAN B,STEIN E,et al. Outcomes af⁃
Blood,2020,135(5):371-380 ter transplant in relapsed/refractory KMT2Ar(MLLr)and
[32]MAZIARZ R T,LEVIS M,PATNAIK M M,et al. Mi⁃ mNPM1(NPM1c)leukemia patients achieving remissions
dostaurin after allogeneic stem cell transplant in patients after menin inhibition:SNDX⁃5613(revumenib)Ph1 expe⁃
with FLT3⁃internal tandem duplication⁃positive acute my⁃ rience[J]. Blood,2022,140(1):914-916
eloid leukemia[J]. Bone Marrow Transplant,2021,56 [收稿日期] 2024-07-13
(5):1180-1189 (本文编辑:唐 震)

