Page 167 - 南京医科大学自然版
P. 167
第45卷第10期 范 亮,肖心儒,张 倩. 乙酰化脯氨酸⁃甘氨酸⁃脯氨酸与肺部疾病[J].
2025年10月 南京医科大学学报(自然科学版),2025,45(10):1528-1536 ·1535 ·
of exposure in users of classic cigarettes,E ⁃ cigarettes, chronic obstructive pulmonary disease[J]. Am J Respir
and heated tobacco products⁃a narrative review[J]. Int J Crit Care Med,2015,192(8):934-942
Mol Sci,2025,26(5):1796 [31]O’REILLY P,JACKSON P L,NOERAGER B,et al. N⁃
[19]HARDISON M T,BROWN M D,SNELGROVE R J,et al. alpha⁃PGP and PGP,potential biomarkers and therapeutic
Cigarette smoke enhances chemotaxis via acetylation of targets for COPD[J]. Respir Res,2009,10(1):38
proline⁃glycine⁃proline[J]. Front Biosci(Elite Ed),2012, [32]SETLAKWE E L,LEMOS K R,LAVOIE⁃LAMOUREUX
4(7):2402-2409 A,et al. Airway collagen and elastic fiber content corre⁃
[20]JACKSON P L,NOERAGER B D,JABLONSKY M J,et lates with lung function in equine heaves[J]. Am J Physi⁃
al. A CXCL8 receptor antagonist based on the structure of ol Lung Cell Mol Physiol,2014,307(3):L252-L260
N⁃acetyl⁃proline⁃glycine⁃proline[J]. Eur J Pharmacol, [33] RÖHN T A,NUMAO S,OTTO H,et al. Drug discovery
2011,668(3):435-442 strategies for novel leukotriene A4 hydrolase inhibitors
[21]LAZENNEC G,RAJARATHNAM K,RICHMOND A. CX⁃ [J]. Expert Opin Drug Discov,2021,16(12):1483-1495
CR2 chemokine receptor⁃a master regulator in cancer and [34] SHARMA N S,LAL C V,LI J D,et al. The neutrophil
physiology[J]. Trends Mol Med,2024,30(1):37-55 chemoattractant peptide proline⁃glycine⁃proline is associ⁃
[22] XIE Y S,KUANG W B,WANG D W,et al. Expanding ated with acute respiratory distress syndrome[J]. Am J
role of CXCR2 and therapeutic potential of CXCR2 antag⁃ Physiol Lung Cell Mol Physiol,2018,315(5):L653-
onists in inflammatory diseases and cancers[J]. Eur J L661
Med Chem,2023,250:115175 [35] LI X H,XIE M D,LU C,et al. Design and synthesis of
[23]KIM S D,LEE H Y,SHIM J W,et al. Activation of CX⁃ leukotriene A4 hydrolase inhibitors to alleviate idiopathic
CR2 by extracellular matrix degradation product acetylated pulmonary fibrosis and acute lung injury[J]. Eur J Med
Pro⁃Gly⁃Pro has therapeutic effects against sepsis[J]. Am Chem,2020,203:112614
J Respir Crit Care Med,2011,184(2):243-251 [36]SUVEIZDYTE K,PATEL D F,PYLE C J,et al. OverZeal⁃
[24] KWON Y W,HEO S C,LEE T W,et al. N⁃acetylated ous degradation of collagen fragment Pro ⁃ Gly ⁃ Pro by
proline ⁃ glycine ⁃ proline accelerates cutaneous wound leukotriene A4 hydrolase(LTA4H)perpetuates fibrosis in
healing and neovascularization by human endothelial IPF[C]//Mechanisms of Lung Injury and Repair. Europe⁃
progenitor cells[J]. Sci Rep,2017,7:43057 an Respiratory Society,2022:127
[25]PATEL D F,PEIRÓ T,SHOEMARK A,et al. An extracel⁃ [37]PROBST C K,MONTESI S B,MEDOFF B D,et al. Vas⁃
lular matrix fragment drives epithelial remodeling and cular permeability in the fibrotic lung[J]. Eur Respir J,
airway hyperresponsiveness[J]. Sci Transl Med,2018,10 2020,56(1):1900100
(455):eaaq0693 [38]KREUTER M,LEDERER D J,MOLINA⁃MOLINA M,et
[26]RODA M A,XU X,ABDALLA T H,et al. Proline⁃glycine⁃ al. Association of angiotensin modulators with the course
proline peptides are critical in the development of smoke⁃ of idiopathic pulmonary fibrosis[J]. Chest,2019,156
induced emphysema[J]. Am J Respir Cell Mol Biol, (4):706-714
2019,61(5):560-566 [39]AWAJI M,SAXENA S,WU L Y,et al. CXCR2 signaling
[27] LIAO S X,WANG Y W,SUN P P,et al. Prospects of promotes secretory cancer ⁃ associated fibroblasts in
neutrophilic implications against pathobiology of chronic pancreatic ductal adenocarcinoma[J]. FASEB J,2020,34
obstructive pulmonary disease:pharmacological insights (7):9405-9418
and technological advances[J]. Int Immunopharmacol, [40] KIM H,JANG Y,RYU J,et al. The dipeptide gly ⁃ pro
2025,144:113634 (GP),derived from Hibiscus sabdariffa,exhibits potent
[28]CHRISTOPOULOU M E,PAPAKONSTANTINOU E, antifibrotic effects by regulating the TGF⁃ β 1⁃ATF4⁃
STOLZ D. Matrix metalloproteinases in chronic obstruc⁃ serine/glycine biosynthesis pathway[J]. Int J Mol Sci,
tive pulmonary disease[J]. Int J Mol Sci,2023,24(4):3786 2023,24(17):13616
[29]WELLS J M,XING D Q,VIERA L,et al. The matrikine [41]MCKELVEY M C,BROWN R,RYAN S,et al. Proteases,
acetyl ⁃ proline ⁃ glycine ⁃ proline and clinical features of mucus,and mucosal immunity in chronic lung disease[J].
COPD:findings from SPIROMICS[J]. Respir Res,2019, Int J Mol Sci,2021,22(9):5018
20(1):254 [42]CWILICHOWSKA N, SWIDERSKA K W,DOBRZYN A,
[30]WELLS J M,JACKSON P L,VIERA L,et al. A random⁃ et al.Diagnostic and therapeutic potential of protease
ized,placebo ⁃ controlled trial of roflumilast.effect on inhibition[J]. Mol Aspects Med,2022,88:101144
proline⁃glycine⁃proline and neutrophilic inflammation in [43]NICOLA T,WENGER N,XU X,et al. A lactobacilli ⁃

