Page 159 - 南京医科大学自然版

第45卷第12期 严舒桐，刘 琪. 机器学习在类风湿性关节炎诊疗及并发症预测中的研究进展［J］.
2025年12月 南京医科大学学报（自然科学版），2025，45（12）：1834-1844 ·1841 ·

利益冲突声明： ［10］TANAKA M，AKIYAMA Y，MORI K，et al. Machine learn⁃
所有作者声明无利益冲突。 ing⁃based analyses of contributing factors for the develop⁃
Conflict of Interests： ment of hypertension：a comparative study［J］. Clin Exp
All authors declare no conflict of interests. Hypertens，2025，47（1）：2449613
作者贡献声明： ［11］SARKER I H. Machine learning：algorithms，real ⁃ world
严舒桐负责文献检索、论文初稿撰写；刘琪负责选题指 applications and research directions［J］. SN Comput Sci，
导、论文检查审核修订。 2021，2（3）：160
Author’s Contributions： ［12］HU X L，LIU X M，XU Y，et al. Machine learning⁃based
YAN Shutong was responsible for literature search，initial prediction model integrating ultrasound scores and clini⁃
draft writing of paper；LIU Qi was responsible for topic selec⁃ cal features for the progression to rheumatoid arthritis in
tion guidance，paper inspection，review and revision. patients with undifferentiated arthritis［J］. Clin Rheuma⁃
tol，2025，44（2）：649-659
［参考文献］
［13］HE X L，WANG M，ZHAO C Y，et al. Deep learning ⁃
［1］ DONG Q，WU J Y，ZHANG H G，et al. Deciphering im⁃
based automatic scoring models for the disease activity of
munometabolic landscape in rheumatoid arthritis：integra⁃
rheumatoid arthritis based on multimodal ultrasound ima⁃
tive multiomics，explainable machine learning and experi⁃
ges［J］. Rheumatology（Oxford），2024，63（3）：866-873
mental validation［J］. J Inflamm Res，2025，18：637-652
［14］SAITO R，FUJII T，MURATA K，et al. Prediction models
［2］ YANG F H，LV J Q，HUANG Y L，et al. A supramolecu⁃
incorporating second metacarpal cortical index for osteo⁃
lar assembly strategy for the treatment of rheumatoid ar⁃ porosis in rheumatoid arthritis：externally validated ma⁃
thritis with ultrasound⁃augmented inflammatory microen⁃ chine learning models developed using data from the
vironment reprograming［J］. Biomaterials，2025，316： KURAMA cohort［J］. Int J Rheum Dis，2024，27（10）：

123006 e15358
［3］ AO Y，LAN Q，YU T H，et al. Cellular senescence⁃associ⁃ ［15］MCDERMOTT G C，HAYASHI K，YOSHIDA K，et al.
ated genes in rheumatoid arthritis：Identification and func⁃ Rheumatoid arthritis，quantitative parenchymal lung fea⁃
tional analysis［J］. PLoS One，2025，20（1）：e0317364 tures and mortality among smokers［J］. Rheumatology
［4］ SAWAN S，KUMARI A，MAJIE A，et al. siRNA ⁃ based （Oxford），2025，64（1）：133-142
nanotherapeutic approaches for targeted delivery in rheu⁃ ［16］朱巧英，丁 炎，宣 旻，等. 类风湿性关节炎超声评分
matoid arthritis［J］. Biomater Adv，2025，168：214120 与 DAS⁃28 评分的相关性研究［J］. 南京医科大学学报
［5］ MAJITHIA V，GERACI S A. Rheumatoid arthritis：diag⁃ （自然科学版），2019，39（1）：90-93
nosis and management［J］. Am J Med，2007，120（11）： ZHU Q Y，DING Y，XUAN W，et al. Study on the correla⁃

936⁃939 tion between ultrasound score and DAS⁃28 score in rheu⁃
［6］ VITTECOQ O，BREVET P，GERARD B，et al. On difficul⁃ matoid arthritis［J］. Journal of Nanjing Medical University
ties to define prognostic factors for clinical practice in （Natural Sciences），2019，39（1）：90-93
rheumatoid arthritis［J］. RMD Open，2024，10（3）： ［17］ZHOU W Y，YANG Y Y，SU L. Development and valida⁃
e004472 tion of predictive factors influencing rheumatoid arthritis
［7］ PARK S H，JEON H L，KIM S C，et al. Utilization of tar⁃ associated with interstitial lung disease［J］. Clin Rheuma⁃
geted disease⁃modifying anti⁃rheumatic drugs（DMARDs） tol，2025，44（2）：601-613
for managing rheumatoid arthritis in the last decade：a two⁃ ［18］RAJPURKAR P，IRVIN J，BALL R L，et al. Deep learn⁃
country comparison［J］. Int J Clin Pharmacol Ther，2021， ing for chest radiograph diagnosis：a retrospective compar⁃
59（10）：639-644 ison of the CheXNeXt algorithm to practicing radiolo⁃
［8］ COX N，MALLEN C D，SCOTT I C. Pharmacological pain gists［J］. PLoS Med，2018，15（11）：e1002686
management in patients with rheumatoid arthritis：a narra⁃ ［19］O’NEIL L J，SPICER V，SMOLIK I，et al. Association of
tive literature review［J］. BMC Med，2025，23（1）：54 a serum protein signature with rheumatoid arthritis develop⁃
［9］ KERSCHBAUMER A，SEPRIANO A，SMOLEN J S，et al. ment［J］. Arthritis Rheumatol，2021，73（1）：78-88
Efficacy of pharmacological treatment in rheumatoid ［20］PRATT A G，SWAN D C，RICHARDSON S，et al. A CD4
arthritis：a systematic literature research informing the T cell gene signature for early rheumatoid arthritis impli⁃
2019 update of the EULAR recommendations for manage⁃ cates interleukin 6⁃mediated STAT3 signalling，particu⁃
ment of rheumatoid arthritis［J］. Ann Rheum Dis，2020， larly in anti⁃citrullinated peptide antibody⁃negative dis⁃
79（6）：744-759 ease［J］. Ann Rheum Dis，2012，71（8）：1374-1381