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第45卷第2期
               ·192 ·                            南 京    医 科 大 学 学         报                        2025年2月


                                         0     10    20    30    40    50    60    70    80    90   100
                      Points
                      Intra & Peri⁃radscore
                                         0.1    0.2     0.3    0.4     0.5    0.6     0.7    0.8     0.9
                                          1
                      Lesion enhancement pattern
                                         0
                                                  1
                      Peritumoral edema
                                         0
                      Total points
                                         0   10   20   30  40   50   60  70   80  90   100  110  120  130
                      N2⁃3 stage ALN rate
                                                          0.1        0.5       0.9
                            Lesion enhancement pattern:0=mass,1=non⁃mass enhancement;Peritumoral edema:0=negative,1=positive.
                                                      图3 联合模型列线图
                                             Figure 3  Nomogram of the combined model



              A            Training datase                    B            Validation dataset
                 1.0                         Clinical AUC:0.770   1.0                         Clinical AUC:0.688
                                             (95%CI:0.707-0.833)                             (95%CI:0.588-0.788)
                                             Intra & Peri⁃model:0.911
                                                                                              Intra & Peri⁃model:0.858
                 0.8                         (95%CI:0.872-0.951)  0.8                        (95%CI:0.770-0.947)
                Sensitivity  0.6             (95%CI:0.885-0.962)  Sensitivity  0.6           (95%CI:0.828-0.955)
                                             Nocnogram AUC:0.923
                                                                                              Nocnogram AUC:0.892
                 0.4
                                                                  0.4
                 0.2                                              0.2
                  0                                                0
                   00   0.2  0.4  0.6  0.8  1.0                     00  0.2  0.4  0.6  0.8  1.0
                            1-Specifieity                                   1-Specifieity
              C                                               D
                 1.0                                              1.0
                 0.8                                              0.8
                Fraction of positives  0.6                       Fraction of positives  0.6


                 0.4
                                                                  0.4
                                                                                 Clinical
                 0.2            Perfectiy calibrated              0.2            Perfectiy calibrated
                                Clinical
                                Intra & Peri⁃                                    Intra & Peri⁃
                  0             Nomogram                           0             Nomogram
                    00   0.2  0.4  0.6  0.8  1.0                     00  0.2  0.4  0.6  0.8  1.0
                        Mean predicted probability                       Mean predicted probability
              E                                               F
                  0.5                          Clinical            0.5                          Clinical
                                               Intra & Peri⁃model                               Intra & Peri⁃model
                  0.4                          Nomogram            0.4                          Nomogram
                                               Treal all           0.3                          Treal all
                  0.3
                                                                                                Treat none
                Net Benefit  0.2                                 Net Benefit  0.2
                                               Treat none
                  0.1
                                                                   0.1
                   0                                                0
                 -0.1                                             -0.1

                    00   0.2  0.4  0.6  0.8  1.0                    00   0.2  0.4  0.6  0.8  1.0
                           Threshold probability                            Threshold probability
                 A,B:ROC curves of training(A)and validation(B)sets;C,D:Calibration curves of training(C)and validation(D)sets;E,F:Decision curves of
              training(E)and validation(F)sets. The X⁃axis indicates the threshold probability. The Y⁃axis represents the net benefit.
                                                     图4  模型的评价和比较
                                      Figure 4  Evaluation and comparison of the developed models
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