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第45卷第8期 张逸悦,李孝媛,高 擎,等. F⁃FDG⁃PET/MR探究早期帕金森病脑代谢网络和功能网络改变特征[J].
2025年8月 南京医科大学学报(自然科学版),2025,45(8):1132-1139 ·1137 ·
A B L R
ITG.L ITG.R PreCG.L PreCG.R SFGdor.L SFGdor.R ORBsup.L ORBsup.R MFG.L MFG.R ORBmid.L ORBmid.R IFGoperc.R
TPOmid.R
TPOmid.L
MTG.R
MTG.L
IFGoperc.L
TPOsup.R
TPOsup.L
STG.R
IFGtriang.L
STG.L
HES.R
IFGtriang.R
HES.L
THA.R
ORBinl.L
THA.L
ORBinl.R
PAL.R
PAL.L
ROL.L
PUT.R
ROL.R
PUT.L
SMA.L
CAU.R
CAU.L SMA.R
OLF.L
PCL.R
PCL.L OLF.R
PCUN.R SFGmed.L
4.520 3 5.928 4
PCUN.L SFGmed.R
ANG.R ORBsupmed.L
ANG.L ORBsupmed.R
SMG.R REC.L
SMG.L REC.R
IPL.R INS.L
IPL.L INS.R
SPG.R ACG.L
SPG.L ACG.R
PoCG.R FFG.R FFG.L IOG.R IOG.L MOG.R PHG.L HIP.R HIP.L PCG.R DCG.R
PoCG.L
DCG.L
PCG.L
MOG.L
SOG.R
SOG.L
LING.R
CUN.L
LING.L
CUN.R
PHG.R
AMYG.L
CAL.L
CAL.R
AMYG.R
A:Fifteen inter⁃brain connections with significantly reduced metabolism in the PD group. 90 AAL ROIs are represented by squares made up of
coloured blocks,with significantly reduced metabolic connectivity indicated by a blue line. B:A three⁃dimensional display with the bars representing
T⁃value changes. L:left;R:right.
图3 显著降低的组间MC值
Figure 3 Significantly reduced intergroup MC values
表3 PD组显著降低的15个脑区间MC
Table 3 The 15 significantly reduced MC between brain regions in the PD group
Metabolic connectivity * Brain region 1 Brain region 2 P
01 CAU.L(Caudate nucleus) ITG.L(Inferior temporal gyrus) 0.001
02 FFG.L(Fusiform gyrus) CAU.L(Caudate nucleus) 0.001
03 CAU.R(Caudate nucleus) ITG.L(Inferior temporal gyrus) 0.001
04 PAL.R(Lenticular nucleus,pallidum) ITG.L(Inferior temporal gyrus) 0.001
05 LING.R(Lingual gyrus) CAU.L(Caudate nucleus) 0.001
06 PreCG.R(Precental gyrus) ROL.R(Rolandic operculum) 0.001
07 MOG.L(Middle occipital gyrus) CAU.L(Caudate nucleus) 0.001
08 ROL.L(Rolandic operculum) STG.L(Superior temporal gyrus) 0.001
09 ROL.R(Rolandic operculum) SMG.R(Supramarginal gyrus) 0.001
10 CAU.L(Caudate nucleus) MTG.L(Middle temporal gyrus) 0.001
11 ROL.L(Rolandic operculum) INS.L(Insula) 0.001
12 ORBinf.R(Inferior frontal gyrus,orbital part) ROL.L(Rolandic operculum) 0.001
13 SOG.L(Superior occipital gyrus) SPG.R(Superior parietal gyrus) 0.001
14 ORBinf.R(Inferior frontal gyrus,orbital part) FFG.R(Fusiform gyrus) 0.001
15 ORBinf.R(Inferior frontal gyrus,orbital part) CAL.R(Calcarine fissure and surrounding cortex) 0.001
*
The metabolic connectivity is between brain region 1 and brain region 2.
的节点)连接以维持基础功能 [22] ;而右侧梭状回作 枢纽退化并存的现象,揭示脑网络在病理压力下的
为高级视觉处理的关键枢纽,其度中心性降低可能 动态平衡——可能以牺牲特定认知功能为代价,来
导致面部识别效率下降,这与 PD 患者常见社会认 优先维持整体架构的完整性。
知障碍有直接关联。这种全局拓扑稳定性与局部 PD 患者脑网络也呈现出显著的 MC 异常,这些

