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第45卷第9期 杨继辰，邱 玲，林建国. 监测免疫治疗反应的颗粒酶B靶向分子影像探针研究进展［J］.
2025年9月 南京医科大学学报（自然科学版），2025，45（9）：1267-1275 ·1275 ·

Imaging，2023，50（2）：275-286 immunotherapy［J］. Sci Adv，2020，6（40）：eabc2777
［34］FU J Y，XI H J，CAI S Y，et al. Development of granzyme ［44］HE S S，LI J C，LYU Y，et al. Near⁃infrared fluorescent
B⁃targeted smart positron emission tomography probes for macromolecular reporters for real ⁃ time imaging and
monitoring tumor early response to immunotherapy［J］. urinalysis of cancer immunotherapy［J］. J Am Chem Soc，
ACS Nano，2024，18（29）：18910-18921 2020，142（15）：7075-7082
［35］ LIANG G L，REN H J，RAO J H. A biocompatible con⁃ ［45］XIE J H，EL RAMI F，ZHOU K X，et al. Multiparameter
densation reaction for controlled assembly of nanostruc⁃ longitudinal imaging of immune cell activity in chimeric
tures in living cells［J］. Nat Chem，2010，2（1）：54-60 antigen receptor T cell and checkpoint blockade therapies
［36］ YANG Y，LIU X Y，WU X F，et al. Enzyme⁃instructed ［J］. ACS Cent Sci，2022，8（5）：590-602
CBT ⁃ cys ⁃ like click cyclization reactions for bioimaging ［46］ SCOTT J I，MENDIVE⁃TAPIA L，GORDON D，et al. A
［J］. Chem Biomed Imaging，2023，2（2）：98-116 fluorogenic probe for granzyme B enables in⁃biopsy evalua⁃
［37］LIN J G，GAO D Y，WANG S J，et al. Stimuli⁃responsive tion and screening of response to anticancer immunothera⁃
macrocyclization scaffold allows In situ self ⁃assembly of pies［J］. Nat Commun，2022，13（1）：2366
radioactive tracers for positron emission tomography imag⁃ ［47］HARRIS J L，PETERSON E P，HUDIG D，et al. Defini⁃
ing of enzyme activity［J］. J Am Chem Soc，2022，144 tion and redesign of the extended substrate specificity of
（17）：7667-7675 granzyme B［J］. J Biol Chem，1998，273（42）：27364-
18
［38］ARCHIBALD S J，ALLOTT L. The aluminium⁃［ F］fluo⁃ 27373
ride revolution：simple radiochemistry with a big impact ［48］SCOTT J I，GUTKIN S，GREEN O，et al. A functional che⁃
for radiolabelled biomolecules［J］. EJNMMI Radiopharm miluminescent probe for in vivo imaging of natural killer
Chem，2021，6（1）：30 cell activity against tumours［J］. Angew Chem Int Ed，
［39］GOGGI J L，RAMASAMY B，TAN Y X，et al. Granzyme 2021，60（11）：5699-5703
B PET imaging stratifies immune checkpoint inhibitor ［49］JANISZEWSKI T，KOŁT S，KAISERMAN D，et al. Nonin⁃
response in hepatocellular carcinoma［J］. Mol Imaging， vasive optical detection of granzyme B from natural killer
2021，2021：9305277 cells with enzyme⁃activated fluorogenic probes［J］. J Biol
［40］GOGGI J L，HARTIMATH S V，XUAN T Y，et al. Gran⁃ Chem，2020，295（28）：9567-9582
zyme B PET imaging of combined chemotherapy and ［50］ZAMBITO G，CHAWDA C，MEZZANOTTE L. Emerging
immune checkpoint inhibitor therapy in colon cancer［J］. tools for bioluminescence imaging［J］. Curr Opin Chem
Mol Imaging Biol，2021，23（5）：714-723 Biol，2021，63：86-94
［41］ GOGGI J L，TAN Y X，HARTIMATH S V，et al. Gran⁃ ［51］CHEN M，ZHOU K X，DAI S Y，et al. In vivo biolumines⁃
zyme B PET imaging of immune checkpoint inhibitor cence imaging of granzyme B activity in tumor response to
combinations in colon cancer phenotypes［J］. Mol Imag⁃ cancer immunotherapy［J］. Cell Chem Biol，2022，29
ing Biol，2020，22（5）：1392-1402 （10）：1556-1567.e6
［42］ ZHAO N，BARDINE C，LOURENÇO A L，et al. In vivo ［52］ZHANG Y，HE S S，CHEN W，et al. Activatable polymeric
measurement of granzyme proteolysis from activated nanoprobe for near ⁃ infrared fluorescence and photo⁃
immune cells with PET［J］. ACS Cent Sci，2021，7（10）： acoustic imaging of T lymphocytes［J］. Angew Chem Int
1638-1649 Ed，2021，60（11）：5921-5927
［43］NGUYEN A，RAMESH A，KUMAR S，et al. Granzyme B ［收稿日期］ 2025-04-09
nanoreporter for early monitoring of tumor response to （本文编辑：蒋 莉）