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第46卷第3期 武有萍,李秀珍,龙明智. 铜稳态与铜死亡在心血管疾病中的研究进展[J].
2026年3月 南京医科大学学报(自然科学版),2026,46(3):466-474 ·473 ·
2010,107(6):787-799 biomarkers related to copper metabolism in patients with
[30] JIANG Y C,HUO Z Y,QI X L,et al. Copper⁃induced pulmonary arterial hypertension[J]. BMC Pulm Med,
tumor cell death mechanisms and antitumor theragnostic 2023,23(1):31
applications of copper complexes[J]. Nanomedicine, [43]CHEN Y F,QI R Q,SONG J W,et al. Sirtuin 7 amelio⁃
2022,17(5):303-324 rates cuproptosis ,myocardial remodeling and heart
[31]ZHANG L,JIANG Y H,FAN C D,et al. MCC950 attenu⁃ dysfunction in hypertension through the modulation of
ates doxorubicin⁃induced myocardial injury in vivo and in YAP/ATP7A signaling[J]. Apoptosis,2024,29(11):
vitro by inhibiting NLRP3 ⁃ mediated pyroptosis[J]. 2161-2182
Biomed Pharmacother,2021,143:112133 [44]QIN Z Y,KONANIAH E S,NELTNER B,et al. Participa⁃
[32]TSANG T,POSIMO J M,GUDIEL A A,et al. Copper is tion of ATP7A in macrophage mediated oxidation of
an essential regulator of the autophagic kinases ULK1/2 LDL[J]. J Lipid Res,2010,51(6):1471-1477
to drive lung adenocarcinoma[J]. Nat Cell Biol,2020,22 [45] KOHNO T,URAO N,ASHINO T,et al. Novel role of
(4):412-424 copper transport protein antioxidant ⁃ 1 in neointimal
[33]GUO H R,OUYANG Y J,YIN H,et al. Induction of formation after vascular injury[J]. Arterioscler Thromb
autophagy via the ROS⁃dependent AMPK⁃mTOR pathway Vasc Biol,2013,33(4):805-813
protects copper ⁃ induced spermatogenesis disorder[J]. [46] LI H L,ZHAO L J,WANG T,et al. Dietary cholesterol
Redox Biol,2022,49:102227 supplements disturb copper homeostasis in multiple organs
[34] XUE Q,YAN D,CHEN X,et al. Copper⁃dependent in rabbits:aorta copper concentrations negatively corre⁃
autophagic degradation of GPX4 drives ferroptosis[J]. late with the severity of atherosclerotic lesions[J]. Biol
Autophagy,2023,19(7):1982-1996 Trace Elem Res,2022,200(1):164-171
[35]LI D L,LIU X M,PI W H,et al. Fisetin attenuates doxoru⁃ [47]TASIC N,TASIC D,OTASEVIC P,et al. Copper and zinc
bicin ⁃ induced cardiomyopathy in vivo and in vitro by concentrations in atherosclerotic plaque and serum in
inhibiting ferroptosis through SIRT1/Nrf2 signaling relation to lipid metabolism in patients with carotid
pathway activation[J]. Front Pharmacol,2022,12:808480 atherosclerosis[J]. Mil Med Pharm J Serbia,2015,72
[36]GAO W,HUANG Z,DUAN J F,et al. Elesclomol induces (9):801-806
copper ⁃ dependent ferroptosis in colorectal cancer cells [48]WANG N,XU X W,LI H L,et al. Atherosclerotic lesion⁃
via degradation of ATP7A[J]. Mol Oncol,2021,15(12): specific copper delivery suppresses atherosclerosis in high⁃
3527-3544 cholesterol ⁃ fed rabbits[J]. Exp Biol Med(Maywood),
[37] YAO B D,WANG Y,XU L,et al. Associations between 2021,246(24):2671-2678
copper and zinc and high blood pressure in children and [49]SEFEROVIC P M,PAULUS W J,ROSANO G,et al. Dia⁃
adolescents aged 8-17 years:an exposure⁃response analy⁃ betic myocardial disorder. A clinical consensus statement
sis of NHANES 2007 ⁃ 2016[J]. Biol Trace Elem Res, of the Heart Failure Association of the ESC and the ESC
2020,198(2):423-429 Working Group on Myocardial & Pericardial Diseases[J].
[38]HE P P,LI H,LIU C Z,et al. U⁃shaped association European J Heart Fail,2024:ejhf.3347
between dietary copper intake and new⁃onset hyperten⁃ [50]DILLMANN W H. Diabetic cardiomyopathy[J]. Circ Res,
sion[J]. Clin Nutr,2022,41(2):536-542 2019,124(8):1160-1162
[39]LEWANDOWSKA M,SAJDAK S,MARCINIAK W,et al. [51]ZARGAR A H,SHAH N A,MASOODI S R,et al. Copper,
First trimester serum copper or zinc levels,and risk of zinc,and magnesium levels in non ⁃ insulin dependent
pregnancy⁃induced hypertension[J]. Nutrients,2019,11 diabetes mellitus[J]. Postgrad Med J,1998,74(877):
(10):2479 665-668
[40]MALEKAHMADI M,FIROUZI S,REZAYI M,et al. As⁃ [52]COOPER G J S,PHILLIPS A R J,CHOONG S Y,et al.
sociation of zinc and copper status with cardiovascular Regeneration of the heart in diabetes by selective copper
diseases and their assessment methods:a review study[J]. chelation[J]. Diabetes,2004,53(9):2501-2508
Mini Rev Med Chem,2020,20(19):2067-2078 [53]HUO S Q,WANG Q,SHI W,et al. ATF3/SPI1/SLC31A1
[41] LIU Y,MIAO J. An emerging role of defective copper signaling promotes cuproptosis induced by advanced gly⁃
metabolism in heart disease[J]. Nutrients,2022,14(3): cosylation end products in diabetic myocardial injury[J].
700 Int J Mol Sci,2023,24(2):1667
[42] WANG L,ZHANG W,LI C,et al. Identification of [54]HUANG L,SHEN R,HUANG L,et al. Association between

