Page 170 - 南京医科大学自然版
P. 170

第46卷第8期
               ·1276 ·                           南 京    医 科 大 学 学         报                        2026年8月


                   controlling autophagosome maturation[J]. Immunity,  [43] TAPIA P J,MARTINA J A,CONTRERAS P S,et al.
                   2012,37(2):223-234                                TFEB and TFE3 regulate STING1 ⁃ dependent immune
             [32]LU Y Y,LI Z J,ZHANG S Q,et al. Cellular mitophagy:  responses by controlling type Ⅰ interferon signaling[J].
                   mechanism,roles in diseases and small molecule pharma⁃  Autophagy,2025,21(9):2028-2045
                   cological regulation[J]. Theranostics,2023,13(2):736-  [44] WANG J L,LI Z,SONG Z X,et al. The effect of spinal
                   766                                               cord STING/ATG5⁃mediated autophagy activation on the
             [33] RICHTER B,SLITER D A,HERHAUS L,et al. Phos⁃        development of diabetic neuropathic pain in rats[J].
                   phorylation of OPTN by TBK1 enhances its binding to Ub  Biochem Biophys Res Commun,2025,760:151686
                   chains and promotes selective autophagy of damaged  [45]KONG L Q,XU P F,SHEN N,et al. STING orchestrates
                   mitochondria[J]. Proc Natl Acad Sci USA,2016,113  microglia polarization via interaction with LC3 in autophagy
                  (15):4039-4044                                     after ischemia[J]. Cell Death Dis,2024,15(11):824
             [34]RAVENHILL B J,BOYLE K B,VON MUHLINEN N,et      [46] SUN J D,YU M Q,DU W Z,et al. The cGAS⁃STING
                   al. The cargo receptor NDP52 initiates selective autophagy  pathway promotes the development of preeclampsia by up⁃
                   by recruiting the ULK complex to cytosol⁃invading bacte⁃  regulating autophagy:mechanisms and implications[J].
                   ria[J]. Mol Cell,2019,74(2):320-329               Int Immunopharmacol,2024,128:111531
             [35]VARGAS J N S,WANG C X,BUNKER E,et al. Spatio⁃  [47]ZHU S N,CHEN Q Y,SUN J D,et al. The cGAS⁃STING
                   temporal control of ULK1 activation by NDP52 and TBK1  pathway promotes endometriosis by up⁃regulating autopha⁃
                   during selective autophagy[J]. Mol Cell,2019,74(2):  gy[J]. Int Immunopharmacol,2023,117:109644
                   347-362                                      [48]ABDULLAH A,MOBILIO F,CRACK P J,et al. STING⁃
             [36]HEO J M,ORDUREAU A,SWARUP S,et al. RAB7A            mediated autophagy is protective against H 2O2 ⁃ induced
                  phosphorylation by TBK1 promotes mitophagy via the  cell death[J]. Int J Mol Sci,2020,21(19):7059
                  PINK ⁃ PARKIN pathway[J]. Sci Adv,2018,4(11):  [49] KHAN S,MENTRUP H L,NOVAK E A,et al. Cyclic
                  eaav0443                                           GMP⁃AMP synthase contributes to epithelial homeostasis
             [37]WILD P,FARHAN H,MCEWAN D G,et al. Phosphoryla⁃      in intestinal inflammation via Beclin⁃1⁃mediated autopha⁃
                   tion of the autophagy receptor optineurin restricts salmo⁃  gy[J]. FASEB J,2022,36(5):e22282
                   nella growth[J]. Science,2011,333(6039):228-233  [50] ZHANG H,LIANG T,DUAN W L,et al. STING modu⁃
             [38]LI J,YANG Y,GE Y,et al. Restricting intracellular   lates HBV⁃related acute⁃on⁃chronic liver failure by media⁃
                   salmonella proliferation by coordinating p⁃TBK1 mediated  ting autophagy and macrophage polarization[J]. Immu⁃
                   mitophagy and xenophagy[J]. Autophagy,2026,22(3):  nobiology,2025,230(1):152860
                   445-467                                      [51] SCHMID M,FISCHER P,ENGL M,et al. The interplay
             [39] GABIG⁃CIMINSKA M. Dysregulated TFEB⁃autophagy⁃     between autophagy and cGAS ⁃ STING signaling and its
                   lysosome pathway links acute COVID⁃19 immunopathology  implications for cancer[J]. Front Immunol,2024,15:
                   to long COVID sequelae[J]. Front Immunol,2025,16:  1356369

                   1708364                                      [52]LI Y J,YANG Q,CHEN H,et al. TFAM downregulation
             [40] RUOLO I,NAPOLITANO S,POSTIGLIONE L,et al.          promotes autophagy and ESCC survival through mtDNA
                   Investigation of dynamic regulation of TFEB nuclear shut⁃  stress⁃mediated STING pathway[J]. Oncogene,2022,41
                   tling by microfluidics and quantitative modelling[J].  (30):3735-3746
                   Commun Biol,2025,8:443                       [53]XU G S,SHU Y N,JIANG M H,et al. Intervention in the
             [41] XU Y F,WAN W. Induction of lysosome biogenesis is a  crosstalk between the cGAS⁃STING pathway and autophagy
                   novel function of the CGAS⁃STING1 pathway[J]. Auto⁃  using an oligonucleotide⁃based bioorthogonal platform for
                   phagy,2025,21(5):1163-1164                        amplifying immunotherapy[J]. Nano Lett,2025,25(24):
             [42]LV B,DION W A,YANG H X,et al. A TBK1⁃independent    9834-9844
                   primordial function of STING in lysosomal biogenesis[J].  (收稿:2026-03-23;修回:2026-04-15;录用:2026-04-26)
                   Mol Cell,2024,84(20):3979-3996                                             (本文编辑:蒋       莉)
   165   166   167   168   169   170   171   172