Page 66 - 南京医科大学学报自然科学版

南京医科大学学报（自然科学版） 第41卷第2期
·216 · Journal of Nanjing Medical University（Natural Sciences） 2021年2月

·临床研究·

富血小板血浆治疗膝骨关节炎的疗效分析

李祖希，范卫民，顾晓园 *
南京医科大学第一附属医院骨科，江苏 南京 210029

［摘 要］ 目的：探讨富血小板血浆（PRP）治疗膝骨关节炎的临床疗效。方法：选取2017年10月—2019年6月因膝骨关节炎
于本院接受住院治疗的患者，根据性别和年龄进行病例配对分组，分为PRP组和对照组各43例，根据Kellgren⁃Lawrence（K⁃L）
分级评估膝骨关节炎严重程度。所有患者均行关节镜清理术，PRP组患者在关节镜手术结束前向关节腔内注射PRP，对照组
仅行单纯关节镜清理术治疗，两组患者治疗后均采取相同的康复锻炼计划。评估并记录治疗前、治疗后1、3、6和12个月时患
者的视觉模拟疼痛评分（VAS）和西安大略和麦克马斯特大学骨关节炎指数（WOMAC），分析临床疗效，观察并记录随访过程中
的不良反应发生情况。结果：所有患者均完成了至少12个月的随访。PRP 组和对照组治疗后各个时间点的VAS及WOMAC
评分均显著低于治疗前（P＜0.05）。PRP组的VAS及WOMAC评分在治疗后1、3个月时显著低于对照组（P＜0.05），而在治疗
后6、12个月时两组患者疗效无显著差异。K⁃L 分级2级的患者使用PRP 后6个月内的VAS 及WOMAC 评分显著低于对照组
（P＜0.05），而在12个月时与对照组疗效无显著差异。K⁃L分级3级的患者仅在治疗后1个月时VAS及WOMAC评分显著低于
对照组（P＜0.05），而在3个月后与对照组疗效无显著差异。结论：使用PRP可以改善膝骨关节炎患者的疼痛症状，恢复膝关
节功能，但持续时间有限。低K⁃L分级的膝骨关节炎患者疗效持续时间更长。
［关键词］ 富血小板血浆；骨关节炎；膝
［中图分类号］ R684.3 ［文献标志码］ A ［文章编号］ 1007⁃4368（2021）02⁃216⁃05
doi：10.7655/NYDXBNS20210212

Clinical effects of platelet⁃rich plasma on knee osteoarthritis：a matched case control study

LI Zuxi，FAN Weimin，GU Xiaoyuan *
Departure of Orthopedic，the First Affiliated Hospital of Nanjing Medical University，Nanjing 210029，China

［Abstract］ Objective：We aimed to identify the clinical effects of platelet⁃rich plasma（PRP）on knee osteoarthritis.Methods：We
performed a matched case control research for patients with osteoarthritis in our hospital from October 2017 to June 2019，according to
gender and age. Both PRP group and the control group enrolled 43 cases. All the patients were evaluated by the severity of
osteoarthritis according to Keligren ⁃ Lawrence classification. The PRP group received an intra ⁃ articularly PRP injection
intraoperatively，while the control group received arthroscopic treatment only. Both groups had the same rehabilitation plan after
surgery. The pain and knee function were assessed by the VAS score and WOMAC score at baseline，1，3，6 and 12 months after the
treatment. The PRP⁃related complications were recorded during the follow⁃up.Results：All enrolled patients were available for 12
months follow⁃up. No serious complication was found in both groups. The VAS and WOMAC scores of both PRP group and the control
group after the treatment were significantly lower than those at the baseline. The VAS and WOMAC scores of PRP group were
significantly lower than those of the control group at 1 and 3 months but not at postoperative 6 and 12 months after the treatment. For
paitents with K⁃L grade 2，the VAS and WOMAC scores of PRP group were significantly lower than those of the control group at 1，3
and 6 months，but not at 12 months after the treatment. Meanwhile，for paitents with K⁃L grade 3，the VAS and WOMAC scores of PRP
group were significantly lower than those of the control group only at 1 months，but not at 3，6 and 12 months after the treatment.
Conclusion：For patients with osteoarthritis，PRP treatment could relieve pain symptoms and restore knee joint function with limited
course. PRP has longer duration of efficacy in patients with lower K⁃L grade.
［Key words］ platelet⁃rich plasma；osteoarthritis；knee
［J Nanjing Med Univ，2021，41（02）：216⁃220］
［基金项目］ 国家自然科学基金面上项目（81974332）
∗
通信作者（Corresponding author），E⁃mail：guxiaoyuan88@sina.com