Page 130 - 南京医科大学学报自然科学版

南京医科大学学报（自然科学版） 第41卷第6期
·908 · Journal of Nanjing Medical University（Natural Sciences） 2021年6月

·临床医学·

APOE基因多态性和晚期糖基化终产物与老年冠心病的相关性

分析

曹雅茹，陈秀梅，王向明，查志敏，刘 欢，郭 妍 *
南京医科大学第一附属医院老年心血管科，江苏 南京 210029

［摘 要］ 目的：对老年冠心病患者载脂蛋白E（apolipoprotein E，APOE）基因多态性与晚期糖基化终产物等相关危险因素进
行分析。方法：在46例老年冠心病患者（冠心病组）和44例非冠心病患者（对照组）中观察APOE基因多态性的分布并用ELISA
法测定血浆羧甲基赖氨酸（carboxy methyl lysine，CML）、可溶性晚期糖基化终末产物受体（soluble receptor for advanced glyca⁃
tion end products，sRAGE）的水平。结果：冠心病组APOEε4等位基因频率明显高于对照组（P＜0.05），冠心病组患者血浆CML、
sRAGE水平高于对照组，但差异无统计学意义。冠心病组APOEε4携带者的血浆CML、sRAGE水平与对照组APOEε4携带者
无显著差异。老年人冠心病危险因素分析得到 APOEε4 携带者患冠心病的风险是非携带者的 3.511 倍（P＜0.05），而 CML、
sRAGE水平与冠心病风险增加无显著相关性。结论：随着年龄增长，APOEε4等位基因仍然是老年冠心病患者的独立危险因
素，而晚期糖基化终产物水平与老年人冠心病之间无显著相关性。
［关键词］ 老年人；冠心病；APOE基因多态性；晚期糖基化终产物

［中图分类号］ R541.4 ［文献标志码］ A ［文章编号］ 1007⁃4368（2021）06⁃908⁃05
doi：10.7655/NYDXBNS20210620

Correlation of APOE gene polymorphism and advanced glycation end products with
coronary heart disease in elderly patients

CAO Yaru，CHEN Xiumei，WANG Xiangming，ZHA Zhimin，LIU Huan，GUO Yan *
Department of Geriatric Cardiology，the First Affiliated Hospital of Nanjing Medical University，Nanjing 210029，
China

［Abstract］ Objective：This study aims to analyze the risk factors related to apolipoprotein E（APOE）gene polymorphism and
advanced glycation end products in elderly patients with coronary heart disease. Methods：The distribution of APOE gene
polymorphism in 46 elderly patients with coronary heart disease and 44 non ⁃ coronary heart disease patients（control group）was
observed，and the plasma levels of carboxy methyl lysine（CML）and soluble receptor for advanced glycation end products（sRAGE）
were determined by ELISA. Results：The allele frequency of ApoE ε4 in coronary heart disease group was significantly higher than
that of the control group（P < 0.05），and the level of plasma CML and sRAGE in coronary heart disease group was higher than that of
the control group，with no statistically significant difference. The plasma CML and sRAGE levels of APOE ε4 carriers in the coronary
heart disease group were not significantly different from those in the control group.The risk factors of coronary heart disease in elderly
patients with APOE ε4 carriers were 3.511 times that of non⁃carriers（P < 0.05），but CMLand sRAGE levels were not significantly
associated with an increased risk of coronary heart disease. Conclusion：With age，APOE ε4 allele remained an independent risk
factor for coronary heart disease in elderly patients，and there was no significant correlation between advanced glycation end products
level and coronary heart disease in elderly patients.
［Key words］ aged；coronary heart disease；APOE gene polymorphism；advanced glycation end products
［J Nanjing Med Univ，2021，41（06）：908⁃912］

［基金项目］ 江苏省干部保健科研课题（BJ18017）
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通信作者（Corresponding author），E⁃mail：guoyan51@hotmail.com