Page 71 - 南京医科大学学报自然科学版

第41卷第8期 南京医科大学学报（自然科学版）
2021年8月 Journal of Nanjing Medical University（Natural Sciences） ·1173 ·

·临床医学·

半乳糖凝集素⁃3对中老年人群颈动脉粥样硬化的预测价值

邱雪婷 ，胡羽杰 ，张紫晨 ，王 敏 ，孙 敏 1*
1
1，2
1
1
南京医科大学第一附属医院内分泌科，江苏 南京 210029；无锡市梁溪区南禅寺街道社区卫生服务中心全科，江苏 无
1 2
锡 214000

［摘 要］ 目的：探索人血清半乳糖凝集素⁃3（galectin⁃3，Gal⁃3）水平对中老年人群颈动脉粥样硬化（carotid atherosclerosis，
CAS）的预测价值。方法：收集2017年9月—2018年3月在无锡市南禅寺卫生服务中心体检人群95例受试者的一般资料及临
床生化指标，检测其 Gal⁃3 水平。并于 2020 年 12 月利用颈动脉超声评估受试者颈动脉内膜中层厚度（carotid intima⁃media
thickness，cIMT）。以Gal⁃3水平的四分位数法将受试者分为4组，分析不同组别的临床资料特点，分别探索所有受试者和其中
诊断为2型糖尿病（type 2 diabetes，T2DM）患者cIMT 与临床资料的相关性，最后使用多元线性回归分析探索T2DM 患者cIMT
的影响因素。结果：Gal⁃3 水平低的受试者，其相应的空腹血糖（fasting blood glucose，FBG）和糖化血红蛋白（glycated hemoglo⁃
bin，HbA1c）较低，cIMT也较低。T2DM患者的双侧cIMT和Gal⁃3正相关（P＜0.05），其Gal⁃3是CAS的影响因素（P＜0.05）。结
论：T2DM患者的Gal⁃3与cIMT相关，对CAS的发展有一定预测价值。
［关键词］ 半乳糖凝集素⁃3；颈动脉粥样硬化；颈动脉内膜中层厚度；2型糖尿病
［中图分类号］ R541.4 ［文献标志码］ A ［文章编号］ 1007⁃4368（2021）08⁃1173⁃05
doi：10.7655/NYDXBNS20210810

Predictive value of galectin ⁃ 3 on carotid atherosclerosis in middle ⁃ aged and elderly

population
1 1，2 1 1 1*
QIU Xueting ，HU Yujie ，ZHANG Zichen ，WANG Min ，SUN Min
1 Department of Endocrinology，the First Affiliated Hospital of Nanjing Medical University，Nanjing 210029；
2 Department of General Medicine，Community Health Service Center of Nanchan Temple Street in Liangxi District of
Wuxi City，Wuxi 214000，China

［Abstract］ Objective： To investigate the predictive value of galectin⁃3（Gal⁃3）on carotid atherosclerosis（CAS）in middle⁃aged and
elderly people. Methods：The general data and clinical biochemical indexes of 95 subjects who underwent physical examination in the
community health service center of Nanchan temple in Wuxi from September 2017 to March 2018 were collected，and their Gal⁃3 level
was detected. In December 2020，carotid artery ultrasound was used to assess carotid intima media thickness（cIMT）. The subjects
were divided into 4 groups by the quartile method of Gal ⁃ 3 level，and the characteristics of different groups were analyzed. The
correlation between cIMT and clinical characteristics in all subjects and then particularly in patients who diagnosed with type 2
diabetes（T2DM）was explored，respectively. Finally，multiple linear regression analysis was used to explore the affecting factors of
cIMT in T2DM patients. Results：Subjects with low Gal⁃3 level had corresponding lower fasting blood glucose（FBG）and glycated
hemoglobin（HbA1c），as well as lower cIMT. Gal⁃3 was related with bilateral cIMT and found as affecting factor of CAS in patients with
T2DM（P < 0.05）. Conclusion：Gal⁃3 is correlated with cIMT and has predictive value for the development of CAS in patients with
T2DM.
［Key words］ galectin⁃3；carotid atherosclerosis；carotid intima⁃media thickness；type 2 diabetes
［J Nanjing Med Univ，2021，41（08）：1173⁃1177］

［基金项目］ 国家重点研发计划课题（2018YFC1314800，2018YFC1314805）
∗
通信作者（Corresponding author），E⁃mail： drsunm@njmu.edu.cn