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抑制,但是这些方式还未通过临床验证。再者,铁 (1):43
死亡仍然缺乏特异性标志物,加上它在不同环境中 [9] BRENNAN M A,COOKSON B T. Salmonella induces
的复杂性,如p53或Ras突变癌细胞,是铁死亡投入 macrophage death by caspase⁃1⁃dependent necrosis[J].
临床应用的挑战。另外,焦亡和坏死性凋亡募集的 Mol Microbiol,2000,38(1):31-40
炎症细胞可能会促血管生成和癌症侵袭,产生免疫 [10] WANG W J,CHEN D,JIANG M Z,et al. Downregulation
of gasdermin D promotes gastric cancer proliferation by
抑制性肿瘤微环境,因此应尽量避免能导致癌症恶
regulating cell cycle⁃related proteins[J]. J Dig Dis,2018,
化的炎性反应。同样,在癌症进展早期,自噬可充
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当肿瘤抑制因子,而在后期阶段,它会促进肿瘤对
[11] WANG Y B,YIN B,LI D N,et al. GSDME mediates cas⁃
治疗的抵抗力,所以对抗化疗耐药依旧是治疗的重 pase⁃3⁃dependent pyroptosis in gastric cancer[J]. Bio⁃
中之重。最后,由于人体内不可直接区分细胞死亡 chem Biophys Res Commun,2018,495(1):1418-1425
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性死亡途径的药物可以广泛应用于癌症治疗。因 [13] REN N,JIANG T,WANG C,et al. LncRNA ADAMTS9⁃
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