Page 68 - 南京医科大学学报自然科学版

南京医科大学学报（自然科学版） 第42卷第4期
·518 · Journal of Nanjing Medical University（Natural Sciences） 2022年4月

·临床研究·

VCAM1 基因 rs2392221 单核苷酸多态性与肾移植术后急性排

异发生的相关性

刘小华 ，魏继福 2*
1
南京医科大学第一附属医院药学部，江苏 南京 210029；南京医科大学附属肿瘤医院药学部，江苏 南京 210000
1 2

［摘 要］ 目的：阐述血管细胞黏附分子 1（vascular cell adhesion molecule 1，VCAM1）基因 rs2392221 单核苷酸多态性（single
nucleotide polymorphism，SNP）与肾移植后急性排异（acute rejection，AR）发生的相关性。方法：回顾性分析南京医科大学第
一附属医院 200 例肾移植患者，根据肾移植术后是否发生急性排异分为急性排异（acute rejection，AR）组 69 例和非 AR 组
131 例。通过二代测序对VCAM1 rs2392221基因型进行检测。采用5个遗传模型分析VCAM1 rs2392221对AR的影响。结合
临床和人口统计学数据，评估 VCAM1 rs2392221 基因多态性与肾移植术后急性排异的关联。结果：5 个遗传模型研究显示
VCAM1 rs2392221 与肾移植术后急性排异显著相关，共显性模型 CC vs. CT：OR=3.71，95%CI：1.82~7.58；CC vs. TT：OR=5.41，
95%CI：1.14~25.75，P < 0.001；显性模型 OR=3.90，95%CI：1.97~7.72，P < 0.001；隐性模型 OR=3.57，95%CI：0.77~16.54，P = 0.357；
超显性模型OR=3.31，95%CI：1.65~6.65，P=0.002；加性模型 OR=3.04，95%CI：1.70~5.43，P=0.034。结论：VCAM1 rs2392221与
肾移植术后急性排异的发生显著相关，检测VCAM1 rs2392221可能有助于早期诊断急性排异的发生。
［关键词］ 肾移植；单核苷酸多态性；急性排异
［中图分类号］ R699.2 ［文献标志码］ A ［文章编号］ 1007⁃4368（2022）04⁃518⁃04
doi：10.7655/NYDXBNS20220409

Single nucleotide polymorphisms of vascular cell adhesion molecule 1（rs2392221）
contributes to the risk of acute rejection in Chinese transplant recipients
1
LIU Xiaohua ，WEI Jifu 2*
2
1 Department of Pharmacy，the First Affiliated Hospital of Nanjing Medical University，Nanjing 210029；Department
of Pharmacy，the Affiliated Cancer Hospital of Nanjing Medical University，Nanjing 210000，China

［Abstract］ Objective：Our study aims to investigate the correlations between single nucleotide polymorphism rs2392221 in vascular
cell adhesion molecule 1（VCAM1）and the risk of acute rejection（AR）in renal transplant recipients. Methods：A total of 200
Chinese renal transplant recipients who underwent kidney transplantation at our center of the First Affiliated Hospital of Nanjing
Medical University，were enrolled and divided into non⁃AR group（n=131）and AR group（n=69）. The VCAM1 rs2392221 genotypes
were detected by next generation sequencing. Five adjusted inheritance models were utilized to investigate the influence of VCAM1
rs2392221 on AR. Combining clinical and demographic data，the association between VCAM1 rs2392221 gene polymorphisms and AR
in renal transplant recipients was evaluated. Results：The SNP rs2392221 on VCAM1 gene exhibited significant correlation with the
occurrence of AR in four of the five models as P < 0.001 in codominant model（CC vs. CT：OR=3.71，95%CI：1.82~7.58；CC vs. TT：
OR=5.41，95%CI：1.14~25.75），P < 0.001 in dominant model（OR=3.90，95% CI：1.97~7.72），P=0.357 in recessive model（OR=3.57，
95% CI：0.77~16.54），P=0.002 in over⁃dominant model（OR=3.31，95% CI：1.65~6.65），P=0.034 in log⁃additive model（OR=3.04，
95% CI：1.70~5.43）. Conclusion：In this study，we observed that SNP rs2392221 was significantly related to the occurrence of AR in
Chinese renal transplant recipients，thereby indicating a potential target for the early diagnosis of AR.
［Key words］ kidney transplantation；single nucleotide polymorphisms；acute rejection
［J Nanjing Med Univ，2022，42（04）：518⁃521］

［基金项目］ 江苏省药学会⁃奥赛康医院药学基金（2021）
∗
通信作者（Corresponding author），E⁃mail：weijifu@hotmail.com