Page 109 - 南京医科大学学报自然科学版

第42卷第6期 南京医科大学学报（自然科学版）
2022年6月 Journal of Nanjing Medical University（Natural Sciences） ·861 ·

·临床研究·

涎腺杨氏模量值在干燥综合征诊断中的可靠性研究

许华宁 ，吴意赟 ，宋旭光 ，郁 佑 ，郭 峰 ，陈剑梅 2*
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1
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南京中医药大学附属医院超声医学科，风湿科，江苏 南京 210029
1 2
［摘 要］ 目的：评价涎腺超声杨氏模量（salivary gland Young’s modulus，SGYM）在干燥综合征（Sjogren’s syndrome，SS）诊断
中的可靠性。方法：观察45例SS患者及51例健康志愿者腮腺、颌下腺、舌下腺的SGYM，评价两组受试者双侧SGYM及两组之
间SGYM的差异；评价医师内部测量SGYM及医师间测量SGYM的一致性；观察受试者性别、年龄、身高、体重及腺体厚度对测
量SGYM的影响。结果：无论SS组与健康组，双侧SGYM的差异均无统计学意义（P＞0.05）；SS组与健康组之间SGYM的差异
均有统计学意义（P＜0.05）；医师内部及医师间测量的SGYM均具有良好的一致性，医师内部的组内相关系数为0.751~0.933，
医师间测量的平均值差值有96.43%~99.02%在一致性界限及其95%置信区间以内。SGYM不受性别、年龄、身高、体重及腺体
厚度的影响。结论：无论SS患者或健康志愿者，SGYM均不受检查医师和受试者自身因素影响，具有良好的可靠性。
［关键词］ 干燥综合征；涎腺；弹性超声；杨氏模量值；可靠性
［中图分类号］ R593.2 ［文献标志码］ A ［文章编号］ 1007⁃4368（2022）06⁃861⁃06
doi：10.7655/NYDXBNS20220615

Reliability of salivary gland Young’s modulus in the diagnosis of Sjogren’s syndrome

1 1 1 2 2 2*
XU Huaning ，WU Yiyun ，SONG Xuguang ，YU You ，GUO Feng ，CHEN Jianmei
1 Department of Ultrasound，Department of Rheumatology，the Affiliated Hospital of Nanjing University of Chinese
2
Medicine，Nanjing 210029，China

［Abstract］ Objective：This study aims to evaluate the reliability of salivary gland ultrasonic Young’s modulus（SGYM）in the
diagnosis of Sjogren’s syndrome（SS）. Methods：SGYM of parotid gland，submandibular gland and sublingual gland in 45 patients with
SS and 51 healthy volunteers were observed，and the differences of SGYM between the two groups were evaluated. To evaluate the
consistency of SGYM measured by physicians and between physicians，the effects of gender，age，height，weight and gland thickness on
the measurement of SGYM were observed. Results：There was no significant difference in bilateral SGYM between SS group and
healthy group（P > 0.05）. The differences of SGYM between SS group and healthy group were statistically significant（P < 0.05）. The
SGYM measured within and among doctors has good consistency. The intra group correlation coefficient within doctors is 0.751~0.933.
The differences of the average value measured between doctors were 96.43% ~99.02% within the consistency limit and its 95%
confidence interval. SGYM was not affected by gender，age，height，weight and gland thickness. Conclusion：Regardless of SS patients
or healthy volunteers，SGYM is not affected by the factors of examiners and subjects，and has good reliability.
［Key words］ Sjogren’s syndrome；salivary gland；elastoultrasound；Young’s modulus value；reliability
［J Nanjing Med Univ，2022，42（06）：861⁃866］

近年来，涎腺超声（salivary gland ultrasound，SGUS） 认可。随着超声新技术的不断更新，剪切波弹性成
已逐步应用到临床，半定量超声评分系统 对干燥 像技术（shear wave elastography，SWE）在 SS 诊断中
［1］
综合征（Sjogren’s syndrome，SS）的诊断价值逐步被 的应用亦有报道 ［2-3］ 。在利用SWE测量SS患者涎腺
杨氏模量值（salivary gland Young’s modulus，SGYM）
［基金项目］ 江苏省中医药科技发展基金计划（YB201909）
时，经常由一名或多名医师进行评估，因此，是否存
∗
通信作者（Corresponding author），E⁃mail：cjm19780102@163.
com 在影响评估结果的因素以及医师内部和医师之间