Page 117 - 南京医科大学学报自然科学版

第42卷第8期 南京医科大学学报（自然科学版）
2022年8月 Journal of Nanjing Medical University（Natural Sciences） ·1159 ·

·临床研究·

SonoVue与Sonazoid在肝脏局灶性病变中的应用价值对比研究

张 雨 ，袁 琳 ，丁 炎 ，汤群锋 ，顾澄宇 ，周锋盛 1*
1
2
1
3
1
3
1 南京医科大学附属无锡人民医院超声医学科，影像科，肝胆外科，江苏 无锡 214023
2
［摘 要］ 目的：探讨SonoVue和Sonazoid超声造影在肝脏局灶性病变中的应用价值。方法：回顾性分析肝脏局灶性病变患者
的临床及超声造影影像学资料，分析肝脏局灶性病变的灌注模式、动脉期、门脉期、延迟期以及血管后期（Kupffer期）的超声造
影增强特征。以病理检查结果为“金标准”，对两种检查方法的诊断效能进行对比分析。结果：以病理作为诊断“金标准”，Son⁃
oVue 和 Sonazoid 超声造影诊断肝脏局灶性病变的准确率、敏感度、特异度、阳性预测值、阴性预测值分别为 88.33%、90.48%、
83.33%、92.68%、78.95%和 93.33%、95.24%、88.89%、95.24%、88.89%。SonoVue 和 Sonazoid 超声造影的诊断结果一致性检验
Kappa值为0.73。两者诊断肝脏局灶性病变的一致性中等，其准确性无统计学意义（P=0.343）。结论：Sonazoid和SonoVue超声
造影对于肝脏局灶性病变的诊断准确性无明显统计学差异，但Sonazoid的图像质量更高，有更高的临床应用价值和广阔的应
用前景。
［关键词］ 超声造影；Sonazoid；SonoVue；肝脏局灶性病变
［中图分类号］ R445.1 ［文献标志码］ A ［文章编号］ 1007⁃4368（2022）08⁃1159⁃06
doi：10.7655/NYDXBNS20220817

The comparative study on the application value of SonoVue and Sonazoid in focal liver
lesions
1 1 1 2 3 1*
ZHANG Yu ，YUAN Lin ，DING Yan ，TANG Qunfeng ，GU Chengyu ，ZHOU Fengsheng
3
1 Department of Ultrasound Medicine，Medical Imaging Department，Department of Hepatobiliary Surgery，Wuxi
2
People's Hospital Affiliated to Nanjing Medical University，Wuxi 214023，China

［Abstract］ Objective：To explore the application value of SonoVue and Sonazoid contrast⁃enhanced ultrasonography in focal liver
lesions. Methods：The clinical and contrast⁃enhanced ultrasound imaging data of the patients with focal liver lesions in our hospital
from January 2020 to December 2021 were analyzed retrospectively. The perfusion pattern，enhancement characteristics of arterial
phase，portal phase，delayed phase and late vascular phase（Kupffer phase）of the contrast medium were analysed. Taking the
pathological examination results as the“gold standard”，the two examination methods were compared and analyzed. Results：Taking
the pathological examination results as the“gold standard”，the accuracy，sensitivity，specificity，positive predictive value and negative
predictive value of SonoVue and Sonazoid contrast⁃enhanced ultrasonography was 88.33%，90.48%，83.33%，92.68%，78.95% and
93.33%，95.24%，88.89%，95.24%，88.89% respectivelv. The kappa value of the consistency test between the two kinds of contrast⁃
enhanced ultrasonography was 0.73. The consistency was at a medium level and the accuracy of SonoVue and Sonazoid contrast ⁃
enhanced ultrasonography in the diagnosis of focal liver lesions was not statistically significant（P=0.373）. Conclusion：Sonazoid and
SonoVue contrast ⁃ enhanced ultrasonography have no significant difference in the diagnostic accuracy of focal liver lesions，but
compared with SonoVue，Sonozoid has a higher quality image，and has the ability to preliminarily judge the differentiation degree of
liver tumors，and can also provide a sufficient time for the scanning of other space occupying lesions of the whole liver. Therefore，
Sonazoid contrast⁃enhanced ultrasonography has higher clinical application value and broader application prospects.
［Key words］ contrast⁃enhanced ultrasound；Sonazoid；SonoVue；liver focal lesions
［J Nanjing Med Univ，2022，42（08）：1159⁃1164］

［基金项目］ 无锡市卫生健康委员会科研项目（Q202142）
∗
通信作者（Corresponding author），E⁃mail：zhoufengsheng1978@163.com