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第43卷第12期 王玉婷,秦亚娟,厉廷有. 髓过氧化物酶抑制剂的研究进展[J].
2023年12月 南京医科大学学报(自然科学版),2023,43(12):1756-1763 ·1761 ·
OH [6] NESSLER K,GRZYBCZAK R,NESSLER M,et al. Asso⁃
OH
ciations between myeloperoxidase and paraoxonase⁃1 and
N
HO type 2 diabetes in patients with ischemic heart disease
N + N [J]. BMC Cardiovasc Disord,2022,22(1):521
O
HO O O
O O [7] LEITGEB U,FURTMUELLER P G,HOFBAUER S,et al.
DMB 4⁃ME NMC The staphylococcal inhibitory protein SPIN binds to hu⁃
图6 作用机制不明的天然产物来源MPO抑制剂 man myeloperoxidase with picomolar affinity but only
Figure 6 MPO inhibitors representing a natural product dampens halide oxidation[J]. J Biol Chem,2022,298
source with an unclear mechanism of action (11):102514
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4 小结与展望 mation and oxidative stress with cardiovascular disease
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MPO 抑制剂的研究是药物研发的热点。目前
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MPO 不 可 逆 抑 制 剂 主 要 包 括 MPO⁃in⁃28 、4⁃
enzymatic and non⁃enzymatic function of myeloperoxidase
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与活性位点结合的化合物包括色胺、色氨酸及其类 glycosylation and binding of the antidepressant parox⁃
似物、吲哚及其类似物等;作用机制不明确的天然 etine in a low⁃resolution crystal structure of human myelo⁃
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活性化合物包括 DMB 、4⁃ME、NMC 等。这些抑
1099-1109
制剂由于抑制了各种损伤中MPO的催化活性,在各
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种炎症疾病中均能起到促进恢复的作用,如动脉粥
sign,synthesis,and biological activity studies on benz⁃
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