Page 90 - 南京医科大学学报自然科学版

南京医科大学学报（自然科学版） 第43卷第3期
·380 · Journal of Nanjing Medical University（Natural Sciences） 2023年3月

·临床研究·

美学区种植同期引导骨再生术骨替代材料留存率的相关因素

分析

周和阳 1，2，3 ，吕佳欣 1，2，3 ，刘栋宇 1，2，3 ，汤春波 1，2，3* ，王瑞霞 1，2，3*

南京医科大学附属口腔医院口腔种植科，南京医科大学口腔疾病研究江苏省重点实验室，江苏省口腔转化医学工程研究中
1 2 3
心，江苏 南京 210029

［摘 要］ 目的：探究美学区引导骨再生术后骨替代材料留存率的相关性因素。方法：收集2019年1月—2021年12月在南京
医科大学附属口腔医院种植科行美学区种植同期行引导骨再生术的 50 例患者术前、术后即刻及术后 6 个月的锥形束 CT 数
据。在mimics19.0软件中重建患者上颌的三维模型，配准计算骨替代材料留存率，并将其与其他临床资料进行相关性分析。
结果：术后6个月的骨替代材料留存率与使用浓缩生长因子、骨劈开及患者凝血酶时间存在统计学相关性（P < 0.05），且患者
凝血酶时间与骨替代材料留存率呈线性负相关（P < 0.01）。结论：进行浓缩生长因子和骨劈开治疗均与术后6个月骨替代材
料留存率提高相关，而凝血酶时间长则骨替代材料留存率低。
［关键词］ 浓缩生长因子；骨替代材料；锥形束CT；引导骨再生术
［中图分类号］ R783.4 ［文献标志码］ A ［文章编号］ 1007⁃4368（2023）03⁃380⁃06
doi：10.7655/NYDXBNS20230312

Analysis of related factors of the retention rate of bone substitute materials in aesthetic
zone implantation with guided bone regeneration

1，2，3 1，2，3 1，2，3 1，2，3* 1，2，3*
ZHOU Heyang ，LÜ Jiaxin ，LIU Dongyu ，TANG Chunbo ，WANG Ruixia
1 Department of Dental Implant and Prosthodontics，the Affiliated Stomatological Hospital of Nanjing Medical
2
3
University；Jiangsu Province Key Laboratory of Oral Diseases，Nanjing Medical University；Jiangsu Province
Engineering Research Center of Stomatological Translational Medicine，Nanjing 210029，China

［Abstract］ Objective：This study aims to investigate the relevant factors of bone substitute materials retention rate after implant
surgery with guided bone regeneration in the aesthetic zone. Methods：From January 2019 to December 2021，the cone beam CT data
of 50 patients who received implant surgery in the aesthetic zone with guided bone regeneration in the implant department of the
Affiliated Stomatological Hospital of Nanjing Medical University were collected before the operation，immediately after the operation
and six months after the operation. Three⁃dimensional model reconstruction of the patient’s maxilla is performed in mimics19.0，along
with registering three reconstructed models and calculating the retention rate of bone substitute materials，and its correlation with other
clinical data was analyzed. Results：The retention rate of bone substitute materials in six months after the operation is statistically
correlated with the use of concentrated growth factor，alveolar ridge splitting technique and thrombin time（P < 0.05）. There is a linear
negative correlation between thrombin time and the retention rate of bone substitute materials（P < 0.01）. Conclusion：Both
concentrated growth factor and alveolar ridge splitting technique are associated with the increase of bone substitute materials’retention
rate in six months after the implant surgery，while long thrombin time is correlated with low bone substitute materials’retention rate.
［Key words］ concentrated growth factor；bone substitute materials；cone beam computed tomography；guided bone regeneration
［J Nanjing Med Univ，2023，43（03）：380⁃385］

［基金项目］ 国家自然科学基金（82170993）；政府间国际科技创新合作重点专项（2018YFE0194100）；南京市科技发展基金
（201605011）
∗
通信作者（Corresponding author），E⁃mail：cbtang@njmu.edu.cn；riebett@sina.com