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第44卷第5期       吴春培,孙正霞,刘 辉,等. 全身麻醉下胸横肌平面⁃胸神经阻滞在乳腺癌手术患者中的价值[J].
                  2024年5月                     南京医科大学学报(自然科学版),2024,44(5):666-671                        ·669 ·


                                            表2 两组患者不同时间点SBP、DBP和HR的比较
                          Table 2 Comparison of SBP,DBP,HR at different time points between the two groups of patients  (x ± s)

                   Indicator    Group       T0          T1         T2          T3          T4        F      P
                 SBP(mmHg)    GA(n=30)   130.0 ± 11.6  099.4 ± 7.2 a  123.5 ± 7.1 a  124.5 ± 9.0 a  111.4 ± 11.2 a  63.718  <0.001
                              TO(n=30)   132.9 ± 13.7  102.5 ± 8.6 a  126.3 ± 14.1 a  127.2 ± 15.5 a  110.7 ± 13.3 a  48.090  <0.001
                                  t        -0.884     -1.529     -0.963      -0.822      -0.220
                                 P         -0.380     -0.132     -0.340      -0.414      -0.826
                 DBP(mmHg)    GA(n=30)   77.1 ± 6.8  060.7 ± 4.9 a  069.5 ± 5.6 a  073.6 ± 6.6 a  068.7 ± 7.2 a  40.076  <0.001
                              TO(n=30)   78.3 ± 7.1  063.1 ± 6.3 a  071.2 ± 8.7 a  075.3 ± 9.0 a  066.5 ± 7.7 a  33.976  <0.001
                                  t        -0.668     -1.653     -0.886      -0.816      -1.104
                                 P         -0.507     -0.104     -0.379      -0.418      -0.274
                 HR(beats/min) GA(n=30)  77.5 ± 7.5  060.7 ± 6.2 a  072.1 ± 7.3 a  071.1 ± 8.0 a  067.0 ± 6.4 a  43.203  <0.001
                              TO(n=30)   79.4 ± 7.6  063.6 ± 5.6 a  073.5 ± 6.2 a  073.8 ± 7.4 a  069.9 ± 5.6 a  34.587  <0.001
                                  t        -0.980     -1.864     -0.804      -1.354      -1.845
                                 P         -0.331     -0.067     -0.425      -0.181      -0.070
                               a
                   Compared with T0,P < 0.05.
                                          表3 两组患者不同时点安静、运动状态VAS评分的比较
                Table 3 Comparison of NRS scores at rest and during movement at different time points between the two groups of patients
                                                                                                        (x ± s)
                     Variable      Group   Postoperative 2 h Postoperative 6 h Postoperative12 h Postoperative 24 h Postoperative 48 h
                VAS at rest       GA(n=30)    2.4 ± 0.5 a  2.8 ± 0.7 a   2.9 ± 0.7     2.5 ± 0.5      2.0 ± 0.4
                                  TO(n=30)    2.0 ± 0.2 a  2.4 ± 0.5 a   2.4 ± 0.5     2.2 ± 0.4      1.9 ± 0.3
                                     t         3.491         2.862        <2.675         1.921         1.439
                                     P         0.001         0.009        <0.010         0.060         0.155
                VAS during movement GA(n=30)  2.9 ± 0.6 a  3.6 ± 0.9 a   3.7 ± 1.0     3.0 ± 0.7      2.5 ± 0.6
                                  TO(n=30)    2.5 ± 0.6 a  2.7 ± 0.8 a   2.8 ± 0.7     2.7 ± 0.6      2.3 ± 0.5
                                     t         2.373         3.517        <4.019         1.942         0.793
                                     P         0.021         0.001        <0.001         0.057         0.431


                                              表4 两组患者术后24 h QoR⁃40 评分的比较
                          Table 4 Comparison of QoR⁃40 scores 24 h postoperatively between the two groups of patients[M(P25,P75)]
                     Group                 Total scores              Emotional state           physical comfort
                    GA(n=30)           183.50(176.00,188.25)       41.00(40.00,43.00)        54.00(51.75,55.25)
                    TO(n=30)           189.00(185.50,192.00)       43.00(42.00,43.25)        56.00(54.00,57.00)
                    Z                        -3.179                     -2.735                    -3.347
                    P                        -0.001                     -0.006                    -0.001
                     Group             Physical independence       Psychological support           Pain
                    GA(n=30)            24.00(23.00,24.25)         31.50(31.00,33.25)        32.00(30.00,33.00)
                    TO(n=30)            24.00(24.00,25.00)         34.00(31.75,34.00)        33.00(32.00,34.00)
                    Z                        -1.848                     -2.722                    -3.069
                    P                        -0.065                     -0.006                    -0.002

                                                                                       [6]
                共识指出了围术期区域神经阻滞联合低剂量阿片                             促进患者术后早期恢复 。羟考酮能同时激动μ、κ
                全麻和多模式镇痛的重要性 。最新的国外乳房整                            受体,对切口痛和内脏痛均具有良好的镇痛作用,
                                         [5]
                形手术ERAS指南更新亦证实术中联合区域神经阻                           多项研究证实羟考酮能提供优于舒芬太尼的镇痛
                                                                                    [7]
                滞,术后多模式、少阿片药物疼痛管理方案能显著                            效果,且患者苏醒快 ,恶心呕吐、皮肤瘙痒                    [8-9] 、免
                减轻疼痛,降低阿片类药物消耗量,缩短住院时间,                           疫抑制   [2,10] 和术后认知功能障碍       [11] 等不良反应发生
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