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第44卷第7期                           南京医科大学学报(自然科学版)
                  2024年7月                   Journal of Nanjing Medical University(Natural Sciences)     ·1025 ·


               ·综     述·

                MRI定量技术在前列腺癌中的研究进展



                高钟秀,顾莹莹,唐立钧           *

                南京医科大学第一附属医院核医学科,江苏 南京 210029



               [摘   要] 多参数磁共振(multiple parameter MRI,mpMRI)是目前前列腺癌无创性检出、定位和分期的首选影像学方法。然
                而,mpMRI图像解读基于阅片者的经验和主观判断,往往会造成诊断偏差。MRI定量技术能够对前列腺病灶的病理生理学特
                性进行更加客观、精准地分析,传统的定量技术包括扩散张量成像、扩散峰度成像、体内非相干运动成像及T2 mapping等,但它
                们各自的局限性使之不能广泛应用于临床。合成磁共振序列是一种新型定量扫描方法,单次扫描后可获得多组基于组织病理
                生理特性的绝对测量值,具有高效率和高容错率,在前列腺癌的诊断中有良好的临床前景。本文对传统及新型MRI定量扫描
                方法在前列腺癌中的临床应用展开综述。
               [关键词] 前列腺癌;磁共振定量技术;扩散张量成像;扩散峰度成像;体内非相干运动成像;合成磁共振成像
               [中图分类号] R445.2                    [文献标志码] A                     [文章编号] 1007⁃4368(2024)07⁃1025⁃06
                doi:10.7655/NYDXBNSN231087


                Research progress of quantitative MRI technologies in prostate cancer

                GAO Zhongxiu,GU Yingying,TANG Lijun *
                Department of Nuclear Medcine,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China

               [Abstract] Currently,multiple parameter MRI(mpMRI)is the preferred imaging modality for the non⁃invasive detection,localization,

                and staging of prostate cancer. However,the interpretation of mpMRI images relies on the experience and subjective judgment of the
                reader,leading to potential diagnostic bias. Quantitative MRI techniques can provide a more objective and precise interpretation for the
                pathophysiological characteristics of prostate lesions. Traditional quantitative techniques include DTI,DKI,IVIM and T2 mapping,but
                their limitations restrict their widespread clinical utility. Nevertheless,synthetic MRI has emerged as a novel quantitative technique
                that enables the acquisition of multiple sets of absolute measurements based on histopathophysiological properties in a single scan.
                With its high scanning efficiency and error tolerance rate,synthetic MRI holds promising clinical prospects in prostate cancer. This
                review discusses the clinical applications of both traditional and novel quantitative MRI techniques in prostate cancer.
               [Key words] prostate cancer;quantitative MRI technology;DTI;DKI;IVIM;synthetic MRI
                                                                            [J Nanjing Med Univ,2024,44(07):1025⁃1030]







                    前列腺癌(prostate cancer,PCA)是男性常见的               各种国际指南推荐为临床可疑 PCA 患者的一线检
                                                                        [1]
                恶性肿瘤,随着血清前列腺特异性抗原(prostate                        查方法 。前列腺成像⁃报告和评分系统(prostate
                specific antigen,PSA)筛查在人群中的广泛开展及                 imaging reporting and data system,PI⁃RADS)依据 T2
                MRI 技术的不断进步,PCA 的检出率大幅度提高。                        加权成像(T2 weighted imaging,T2WI)、扩散加权成
                多参数磁共振(multiple parameter MRI,mpMRI)的             像(diffusion weighted imaging,DWI)和动态对比增
                引入使得医生能更准确地评估和取检可疑病灶,被                            强扫描(dynamic contrast enhancement,DCE)序列将
                                                                  病灶可能为 PCA 的概率进行 1~5 分的评分,并建议
                                                                                           [2]
               [基金项目] 江苏省医学重点人才基金项目(ZDRCB2016003)                 3~5分的病灶接受靶向活检 。但是前列腺mpMRI
                ∗                                                 评估病灶的结果可能会因放射科医生的经验、检查
                通信作者(Corresponding author),E⁃mail:tanglijun@njmu.edu.cn
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