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               ·1086 ·                           南 京    医 科 大 学 学         报                        2024年8月


                                               表4 COPD患者动静状态下SpO2特点
                                            Table 4 The characteristics of SpO 2 in COPD

                    Index     control group(n=21)COPD⁃A group(n=23)COPD⁃B group(n=17)COPD⁃C group(n=18) Statistical value  P
              SpO2rest (%,x ± s)  97.05 ± 1.800  96.35 ± 1.61 0  96.47 ± 1.9700  97.11 ± 2.320   00.836 ##  0.478
                                                         0
              Prest (bpm,x ± s)  80.33 ± 10.88  80.13 ± 12.24 0  91.24 ± 16.73 ab  81.33 ± 8.880  03.351 ##  0.023
              SpO2min (%,x ± s)  94.10 ± 2.490  91.57 ± 3.95 0  90.59 ± 3.74 0   92.61 ± 3.890   03.470 ##  0.020
                                                                         a
                                                         a
              SpO2mean (%,x ± s)  96.26 ± 1.940  94.16 ± 2.93 0  93.62 ± 2.76 0  95.09 ± 3.080   03.600 ##  0.017
                                                                         a
                                                         a
              DA(min ,x ± s)   214.84 ± 115.47  350.08 ± 175.77 a  382.20 ± 165.27 a  294.67 ± 185.08  04.067 ##  0.010
                    -1
              EID[n(%)]            0(0)0,        9(39.1)0 0      7(41.2)00         04(22.2) a    13.762 ##  0.002
                                                                       a
                                                       a
              T94 [%,M(P25,P75)]  10.83(0,48.54)  28.06(6.67,87.81) 63.16(11.24,94.80)  17.56(0,84.07)  06.512 ##  0.089
              T92 [%,M(P25,P75)]  00.0(0,2.08)  4.17(0,51.25)0 0  4.99(0,74.37)00  000 0(0,61.25)  08.567 ##  0.036
                                                                          a
              T90 [%,M(P25,P75)]   0(0,0)       00(0,23.69) a    0(0,42.57) a    00 0(0,3.96)    10.842 ##  0.013
              T88 [%,M(P25,P75)]   0(0,0)        0(0,0)00 0      0(0,8.45)         0(0,0)        08.726 ##  0.033
                                                                         a
              Pmax (bpm,x ± s)  119.67 ± 21.680  115.43 ± 28.460 0  122.24 ± 19.4700  119.44 ± 20.710  00.298 ##  0.827
              SBPrest (mmHg,x ± s) 130.88 ± 21.780  129.93 ± 16.060 0  135.33 ± 28.1300  131.20 ± 14.900  00.167 ##  0.918
              DBPrest (mmHg,x ± s)  79.00 ± 12.54  77.33 ± 7.500 0  79.20 ± 6.8400  79.20 ± 6.840  00.967 ##  0.416
                 without#:F value in ANOVA;#:H value in Kruskal⁃Wallis H test;##:statistic in Fisher’s exact test by used least significant difference for pair⁃
              wise multiple comparisons;a:compared with the control group,P < 0.05,b:compared with COPD⁃A group,P < 0.05.

                                                  表5   COPD患者运动耐力特点
                                       Table 5 The characteristics of exercise tolerance in COPD       (x ± s)

                    Index     Control group(n=21) COPD⁃A group(n=23) COPD⁃B group(n=17) COPD⁃C group(n=18)  F  P
                6MWD(m)         541.62 ± 61.13   514.17 ± 79.65    498.35 ± 77.20   521.00 ± 77.53  1.127  0.344
                6MWD%Pred(%)    104.25 ± 12.93   091.80 ± 13.24   0 92.83 ± 14.47   0 97.50 ± 16.10  3.370  0.020
                METs             03.58 ± 0.29     03.45 ± 0.38     0 3.37 ± 0.37     0 3.48 ± 0.37  1.127  0.344
                6MWW(m∙kg)      35 461 ± 6 537   31 625 ± 8 021    31 486 ± 6 886   35 820 ± 7 682  2.028  0.178
                DDR(min ∙m )     02.37 ± 1.23     04.25 ± 2.47      04.74 ± 2.28     0 3.46 ± 2.14  4.843  0.004
                       -1
                          -1
                                              表6 总样本运动耐力、SpO2的相关性分析
               Table 6 The correlation analysis of SpO 2 and exercise tolerance with other general COPD parameters in the total samples
                                                                    DA              DDR          6MWD%Pred
                                  SpO2min         SpO2mean
                   Index
                                r       P       r       P        r       P       r       P        r       P
               Age            -0.052   0.651  -0.069   0.453   -0.068   0.552  -0.015   0.898   -0.312   0.005
               BMI            -0.160   0.159  -0.192   0.089   -0.187   0.098  -0.148   0.194   -0.205   0.069
               Smoking index  -0.005 *  0.967  -0.014 *  0.903  -0.033 *  0.770  -0.081 *  0.477  -0.283 *  0.011
               mMRC           -0.221 *  0.053  -0.245 *  0.031  -0.248 *  0.030  -0.341 *  0.002  -0.490 *  <0.001
               CAT            -0.192 *  0.094  -0.159 *  0.167  -0.168 *  0.145  -0.244 *  0.033  -0.391 *  <0.001
               FEV1%Pred      -0.373   0.001  -0.393  <0.001   -0.418  <0.001  -0.447  <0.001   -0.439  <0.001
               FVC%Pred       -0.350   0.002  -0.383  <0.001   -0.408  <0.001  -0.439  <0.001   -0.426  <0.001
               DLCO%Pred      -0.307   0.012  -0.191   0.124   -0.191   0.124  -0.268   0.029   -0.383   0.001
               DLCO/VA%Pred   -0.336   0.005  -0.225   0.064   -0.226   0.064  -0.295   0.015   -0.393   0.001
                              -0.506 *  <0.001  -0.596 *  <0.001  -0.594 *  <0.001  -0.582 *  <0.001  -0.005 *  0.963
               SpO2rest
               6MWD           -0.114   0.317  -0.101   0.376   -0.113   0.321    -        -       -       -
               6MWD%Pred      -0.046   0.687  -0.030   0.792   -0.051   0.656    -        -       -       -
                    ①
                 DDR = DDR to follow a normal distribution. without*:Pearson correlation coefficient. *:Spearman correlation coefficient.
              统计学意义,这3个变量对DDR 贡献58.3%的变异                             另外,对 COPD 组内进行运动耐力、SpO2 与
                                           ①
             (表7)。                                              COPD 其 他 常 用 评 估 指 标 的 相 关 性 分 析 显 示 ,
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