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表4 COPD患者动静状态下SpO2特点
Table 4 The characteristics of SpO 2 in COPD
Index control group(n=21)COPD⁃A group(n=23)COPD⁃B group(n=17)COPD⁃C group(n=18) Statistical value P
SpO2rest (%,x ± s) 97.05 ± 1.800 96.35 ± 1.61 0 96.47 ± 1.9700 97.11 ± 2.320 00.836 ## 0.478
0
Prest (bpm,x ± s) 80.33 ± 10.88 80.13 ± 12.24 0 91.24 ± 16.73 ab 81.33 ± 8.880 03.351 ## 0.023
SpO2min (%,x ± s) 94.10 ± 2.490 91.57 ± 3.95 0 90.59 ± 3.74 0 92.61 ± 3.890 03.470 ## 0.020
a
a
SpO2mean (%,x ± s) 96.26 ± 1.940 94.16 ± 2.93 0 93.62 ± 2.76 0 95.09 ± 3.080 03.600 ## 0.017
a
a
DA(min ,x ± s) 214.84 ± 115.47 350.08 ± 175.77 a 382.20 ± 165.27 a 294.67 ± 185.08 04.067 ## 0.010
-1
EID[n(%)] 0(0)0, 9(39.1)0 0 7(41.2)00 04(22.2) a 13.762 ## 0.002
a
a
T94 [%,M(P25,P75)] 10.83(0,48.54) 28.06(6.67,87.81) 63.16(11.24,94.80) 17.56(0,84.07) 06.512 ## 0.089
T92 [%,M(P25,P75)] 00.0(0,2.08) 4.17(0,51.25)0 0 4.99(0,74.37)00 000 0(0,61.25) 08.567 ## 0.036
a
T90 [%,M(P25,P75)] 0(0,0) 00(0,23.69) a 0(0,42.57) a 00 0(0,3.96) 10.842 ## 0.013
T88 [%,M(P25,P75)] 0(0,0) 0(0,0)00 0 0(0,8.45) 0(0,0) 08.726 ## 0.033
a
Pmax (bpm,x ± s) 119.67 ± 21.680 115.43 ± 28.460 0 122.24 ± 19.4700 119.44 ± 20.710 00.298 ## 0.827
SBPrest (mmHg,x ± s) 130.88 ± 21.780 129.93 ± 16.060 0 135.33 ± 28.1300 131.20 ± 14.900 00.167 ## 0.918
DBPrest (mmHg,x ± s) 79.00 ± 12.54 77.33 ± 7.500 0 79.20 ± 6.8400 79.20 ± 6.840 00.967 ## 0.416
without#:F value in ANOVA;#:H value in Kruskal⁃Wallis H test;##:statistic in Fisher’s exact test by used least significant difference for pair⁃
wise multiple comparisons;a:compared with the control group,P < 0.05,b:compared with COPD⁃A group,P < 0.05.
表5 COPD患者运动耐力特点
Table 5 The characteristics of exercise tolerance in COPD (x ± s)
Index Control group(n=21) COPD⁃A group(n=23) COPD⁃B group(n=17) COPD⁃C group(n=18) F P
6MWD(m) 541.62 ± 61.13 514.17 ± 79.65 498.35 ± 77.20 521.00 ± 77.53 1.127 0.344
6MWD%Pred(%) 104.25 ± 12.93 091.80 ± 13.24 0 92.83 ± 14.47 0 97.50 ± 16.10 3.370 0.020
METs 03.58 ± 0.29 03.45 ± 0.38 0 3.37 ± 0.37 0 3.48 ± 0.37 1.127 0.344
6MWW(m∙kg) 35 461 ± 6 537 31 625 ± 8 021 31 486 ± 6 886 35 820 ± 7 682 2.028 0.178
DDR(min ∙m ) 02.37 ± 1.23 04.25 ± 2.47 04.74 ± 2.28 0 3.46 ± 2.14 4.843 0.004
-1
-1
表6 总样本运动耐力、SpO2的相关性分析
Table 6 The correlation analysis of SpO 2 and exercise tolerance with other general COPD parameters in the total samples
DA DDR 6MWD%Pred
SpO2min SpO2mean
Index
r P r P r P r P r P
Age -0.052 0.651 -0.069 0.453 -0.068 0.552 -0.015 0.898 -0.312 0.005
BMI -0.160 0.159 -0.192 0.089 -0.187 0.098 -0.148 0.194 -0.205 0.069
Smoking index -0.005 * 0.967 -0.014 * 0.903 -0.033 * 0.770 -0.081 * 0.477 -0.283 * 0.011
mMRC -0.221 * 0.053 -0.245 * 0.031 -0.248 * 0.030 -0.341 * 0.002 -0.490 * <0.001
CAT -0.192 * 0.094 -0.159 * 0.167 -0.168 * 0.145 -0.244 * 0.033 -0.391 * <0.001
FEV1%Pred -0.373 0.001 -0.393 <0.001 -0.418 <0.001 -0.447 <0.001 -0.439 <0.001
FVC%Pred -0.350 0.002 -0.383 <0.001 -0.408 <0.001 -0.439 <0.001 -0.426 <0.001
DLCO%Pred -0.307 0.012 -0.191 0.124 -0.191 0.124 -0.268 0.029 -0.383 0.001
DLCO/VA%Pred -0.336 0.005 -0.225 0.064 -0.226 0.064 -0.295 0.015 -0.393 0.001
-0.506 * <0.001 -0.596 * <0.001 -0.594 * <0.001 -0.582 * <0.001 -0.005 * 0.963
SpO2rest
6MWD -0.114 0.317 -0.101 0.376 -0.113 0.321 - - - -
6MWD%Pred -0.046 0.687 -0.030 0.792 -0.051 0.656 - - - -
①
DDR = DDR to follow a normal distribution. without*:Pearson correlation coefficient. *:Spearman correlation coefficient.
统计学意义,这3个变量对DDR 贡献58.3%的变异 另外,对 COPD 组内进行运动耐力、SpO2 与
①
(表7)。 COPD 其 他 常 用 评 估 指 标 的 相 关 性 分 析 显 示 ,