Page 112 - 南京医科大学学报自然科学版
P. 112
第43卷第12期
·1728 · 南 京 医 科 大 学 学 报 2023年12月
结果显示羟考酮组中有 4 例患者(10%)术中 [8] 黄 媚,李 娟,杨成伟. 意识指数监测对脑微血管减
IoC2值>50持续2 min以上,为保证患者手术期间完 压术患者术后早期恢复质量的影响[J]. 临床麻醉学杂
善的麻醉及镇痛,加用了小剂量瑞芬太尼持续静脉 志,2020,36(6):555-558
泵注[0.05~0.10 μg/(kg·min)]维持麻醉及镇痛,取 [9] WODEHOUSE T,DEMOPOULOS M,PETTY R,et al. A
randomized pilot study to investigate the effect of opioids
得了满意的效果。这提示在乳腺癌保乳手术中单
on immunomarkers using gene expression profiling during
独应用羟考酮联合丙泊酚全凭静脉麻醉,仍有少部
surgery[J]. Pain,2019,160(12):2691-2698
分患者可能存在镇痛不足,需要加强术中监测,及
[10] FRANCHI S,MOSCHETTI G,AMODEO G,et al. Do all
时发现并进行补救处理。也可以通过联合区域神 opioid drugs share the same immunomodulatory proper⁃
经阻滞,如胸椎旁神经阻滞、胸部神经阻滞等,多模 ties? A review from animal and human studies[J]. Front
式镇痛途径减少阿片类药物的使用量,从而减少阿 Immunol,2019,10:2914
片类药物的不良反应。 [11] 何自静,陈 静,李 密,等. 羟考酮与舒芬太尼用于乳
综上所述,羟考酮联合丙泊酚全凭静脉麻醉可 腺癌手术全身麻醉的比较[J]. 临床麻醉学杂志,2017,
安全用于乳腺癌保乳手术中,患者围手术期镇痛效 33(3):269-272
[12] HAN L,SU Y,XIONG H,et al. Oxycodone versus sufent⁃
果确切、不良反应发生率低,恢复质量高。
anil in adult patient⁃controlled intravenous analgesia after
[参考文献] abdominal surgery[J]. Medicine,2018,97(31):e11552
[13] 王维嘉,任立英,龚亚红,等. 盐酸羟考酮注射液用于术
[1] SAGIROGLU J,OZEMIR I A,EREN T,et al. Comparison
后患者静脉自控镇痛的回顾性分析[J]. 中国医学科学
of oncoplastic breast surgery,non⁃oncoplastic breast con⁃
serving surgery and mastectomy in early breast cancer:a 院学报,2020,42(1):91-95
single center retrospective study[J]. Arch Iran Med, [14] KOCH S,AHLBURG P,SPANGSBERG N,et al. Oxyco⁃
2021,24(5):390-396 done vs. fentanyl in the treatment of early post⁃operative
[2] 邓 军,贾建光,高 愿,等. 保乳手术和改良根治术治 pain after laparoscopic cholecystectomy:a randomised
疗早期乳腺癌的临床对比研究[J]. 中华全科医学, double⁃blind study[J]. Acta Anaesthesiol Scand,2008,
2018,16(4):533-537 52(6):845-850
[3] WRUBEL E,NATWICK R,WRIGHT G P. Breast⁃con⁃ [15] JINDAL P,GUPTA P,KUMAR N. Role of pre⁃emptive
serving therapy is associated with improved survival com⁃ Huff’s manoeuvre and acupressure in reducing the inci⁃
dence of fentanyl induced cough;a risk factor for postop⁃
pared with mastectomy for early ⁃ stage breast cancer:a
propensity score matched comparison using the national erative nausea vomiting in female patients:a prospective
randomised controlled study[J]. Indian J Anaesth,2019,
cancer database[J]. Ann Sur Oncol,2020,28(2):914-
919 63(10):834
[4] RATOSA I,PLAVC G,PISLAR N,et al. Improved surviv⁃ [16] TAN W,LI S,LIU X,et al. Prophylactic intravenous lido⁃
al after breast⁃conserving therapy compared with mastec⁃ caine at different doses for fentanyl⁃induced cough(FIC):
tomy in stage Ⅰ⁃Ⅱ A breast cancer[J]. Cancers,2021, a meta⁃analysis[J]. Sci Rep,2018,8(1):9946
13(16):4044 [17] 郑 瑄,蒋益民. HPC联合深呼吸法可有效抑制芬太尼
[5] SUN Q,LI Z,WANG Z,et al. Immunosuppression by opi⁃ 诱发的咳嗽反应[J]. 基因组学与应用生物学,2018,37
oids:mechanisms of action on innate and adaptive immu⁃ (9):4062-4068
nity[J]. Biochem Pharmacol,2023,209:115417 [18] DAI B,CAO X. Comparing the different oxycodone doses
[6] FENG X,YANG P,LIAO Z,et al. Comparison of oxycodo⁃ of prevent oxycodone for prevention of preventing fentanyl
ne and sufentanil in patient⁃controlled intravenous analge⁃ ⁃ induced cough during induction of general anaesthesia
sia for postoperative patients:a meta⁃analysis of random⁃ [J]. Int J Clin Pract,2020,74(12):e13642
ized controlled trials[J]. Chin Med J,2023,136(1):45-52 [19] 朱文智,王东信. 羟考酮在全身麻醉诱导中的临床应用
[7] 左都坤,杨贵英,陈 凤,等. 意识指数监测腹腔镜手术 [J]. 临床麻醉学杂志,2016,32(4):341-343
中七氟醚麻醉深度的效果[J]. 临床麻醉学杂志,2023, [收稿日期] 2023-07-29
39(2):119-123 (本文编辑:唐 震)

