Page 107 - 南京医科大学学报自然科学版
P. 107
第44卷第1期 姜玉莹,杨 硕. 肠上皮发育稳态及其调节信号[J].
2024年1月 南京医科大学学报(自然科学版),2024,44(01):089-104 ·101 ·
[69] BARKER N,VAN ES J H,KUIPERS J,et al. Identifica⁃ lar inheritance of a Cre⁃activated reporter gene to deter⁃
tion of stem cells in small intestine and colon by marker mine paneth cell longevity in the murine small intestine
gene Lgr5[J]. Nature,2007,449(7165):1003-1007 [J]. Dev Dyn,2005,233(4):1332-1336
[70] CHENG H,LEBLOND C P. Origin,differentiation and re⁃ [85] METCALFE C ,KLJAVIN N M,YBARRA R,et al. Lgr5 +
newal of the four main epithelial cell types in the mouse stem cells are indispensable for radiation⁃induced intesti⁃
small intestine V. Unitarian theory of the origin of the four nal regeneration[J]. Stem Cell,2014,14(2):149-159
epithelial cell types[J]. Am J Anat,1974,141(4):537-561 [86] AYYAZ A,KUMAR S,SANGIORGI B,et al. Single⁃cell
[71] MIRON N,CRISTEA V. Enterocytes:active cells in tole⁃ transcriptomes of the regenerating intestine reveal a revival
rance to food and microbial antigens in the gut[J]. Clin stem cell[J]. Nature,2019,569(7754):121-125
Exp Immunol,2012,167(3):405-412 [87] JEON M K. Intestinal barrier:molecular pathways and
[72] RODRÍGUEZ⁃COLMAN M J,SCHEWE M,MEERLO M, modifiers[J]. World J Gastrointest Pathophysiol,2013,4
et al. Interplay between metabolic identities in the intesti⁃ (4):94
nal crypt supports stem cell function[J]. Nature,2017, [88] HONG S N,DUNN J C Y,STELZNER M,et al. Concise
543(7645):424-427 review:the potential use of intestinal stem cells to treat
[73] KIM Y S,HO S B. Intestinal goblet cells and mucins in patients with intestinal failure[J]. Stem Cells Transl Med,
health and disease:recent insights and progress[J]. Curr 2017,6(2):666-676
Gastroenterol Rep,2010,12(5):319-330 [89] PINTO D,GREGORIEFF A,BEGTHEL H,et al. Canoni⁃
[74] SPECIAN R D,OLIVER M G. Functional biology of intes⁃ cal Wnt signals are essential for homeostasis of the intesti⁃
tinal goblet cells[J]. Am J Physiol Cell Physiol,1991,260 nal epithelium[J]. Genes Dev,2003,17(14):1709-1713
(2):C183-C193 [90] GILES R H,VAN ES J H,CLEVERS H. Caught up in a
[75] GUSTAFSSON J K,JOHANSSON M E V. The role of gob⁃ Wnt storm:wnt signaling in cancer[J]. Biochim Biophys
let cells and mucus in intestinal homeostasis[J]. Nat Rev Acta,2003,1653(1):1-24
Gastroenterol Hepatol,2022,19(12):785-803 [91] CZERWINSKI M,SHROYER N F,SPENCE J R. WNT
[76] GRIBBLE F M,REIMANN F. Enteroendocrine cells:che⁃ physiology of the gastrointestinal tract[M]. Amsterdam:
mosensors in the intestinal epithelium[J]. Annu Rev Elsevier,2018:185-196
Physiol,2016,78:277-299 [92] GREGORIEFF A,PINTO D,BEGTHEL H,et al. Expres⁃
[77] MACE O J,TEHAN B,MARSHALL F. Pharmacology and sion pattern of Wnt signaling components in the adult in⁃
physiology of gastrointestinal enteroendocrine cells[J]. testine[J]. Gastroenterology,2005,129(2):626-638
Pharmacol Res Perspect,2015,3(4):1-26 [93] KWONG L N,DOVE W F. Advances in experimental medi⁃
[78] FURNESS J B,RIVERA L R,CHO H J,et al. The gut as cine and biology[M]. New York,NY:Springer New York,
a sensory organ[J]. Nat Rev Gastroenterol Hepatol,2013, 2009:85-106
10(12):729-740 [94] VAN ES J H,JAY P,GREGORIEFF A,et al. Wnt signal⁃
[79] HOWITT M R,LAVOIE S,MICHAUD M,et al. Tuft cells, ling induces maturation of Paneth cells in intestinal crypts
taste⁃chemosensory cells,orchestrate parasite type 2 im⁃ [J]. Nat Cell Biol,2005,7(4):381-386
munity in the gut[J]. Science,2016,351(6279):1329- [95] SANCHO R,CREMONA C A,BEHRENS A. Stem cell
1333 and progenitor fate in the mammalian intestine:Notch
[80] GERBE F,SIDOT E,SMYTH D J,et al. Intestinal epithe⁃ and lateral inhibition in homeostasis and disease[J].
lial tuft cells initiate type 2 mucosal immunity to helminth EMBO Rep,2015,16(5):571-581
parasites[J]. Nature,2016,529(7585):226-230 [96] KOCH U,LEHAL R,RADTKE F. Stem cells living with a
[81] HARRIS N. The enigmatic tuft cell in immunity[J]. Sci⁃ Notch[J]. Development,2013,140(4):689-704
ence,2016,351(6279):1264-1265 [97] HARAMIS A P G,BEGTHEL H,VAN DEN BORN M,et
[82] BEUMER J,CLEVERS H. Cell fate specification and al. De novo crypt formation and juvenile polyposis on
differentiation in the adult mammalian intestine[J]. Nat BMP inhibition in mouse intestine[J]. Science,2004,303
Rev Mol Cell Biol,2021,22(1):39-53 (5664):1684-1686
[83] WATSON A J M,HUGHES K R. TNF⁃α⁃induced intesti⁃ [98] SATO T,VRIES R G,SNIPPERT H J,et al. Single Lgr5
nal epithelial cell shedding:implications for intestinal stem cells build crypt⁃villus structures in vitro without a
barrier function[J]. Ann N Y Acad Sci,2012,1258(1): mesenchymal niche[J]. Nature,2009,459(7244):262-
1-8 265
[84] IRELAND H,HOUGHTON C,HOWARD L,et al. Cellu⁃ [99] JORISSEN R N,WALKER F,POULIOT N,et al. The

