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EGF receptor family［M］. Amsterdam：Elsevier，2003： initiation［J］. Cancer Lett，2015，369（2）：336-343
33-55 ［115］CHEN Y，YE Z H，SEIDLER U，et al. Microenvironmen⁃
［100］SATO T，VAN ES J H，SNIPPERT H J，et al. Paneth cells tal regulation of intestinal stem cells in the inflamed intes⁃
constitute the niche for Lgr5 stem cells in intestinal crypts tine［J］. Life Sci，2021，273：119298
［J］. Nature，2011，469（7330）：415-418 ［116］SAHA S，ARANDA E，HAYAKAWA Y，et al. Macrophage
［101］DIGNASS A U，STURM A. Peptide growth factors in the ⁃ derived extracellular vesicle ⁃ packaged WNTs rescue
intestine［J］. Eur J Gastroenterol Hepatol，2001，13（7）： intestinal stem cells and enhance survival after radiation
763-770 injury［J］. Nat Commun，2016，7：13096
［102］PAN D. The hippo signaling pathway in development and ［117］LINDEMANS C A，CALAFIORE M，MERTELSMANN A
cancer［J］. Dev Cell，2010，19（4）：491-505 M，et al. Interleukin⁃22 promotes intestinal⁃stem⁃cell⁃me⁃
［103］CAI J，ZHANG N L，ZHENG Y G，et al. The Hippo signal⁃ diated epithelial regeneration［J］. Nature，2015，528
ing pathway restricts the oncogenic potential of an intesti⁃ （7583）：560-564
nal regeneration program［J］. Genes Dev，2010，24（21）： ［118］GRONKE K，HERNÁNDEZ P P，ZIMMERMANN J，et al.
2383-2388 Interleukin⁃22 protects intestinal stem cells against geno⁃
［104］BEUMER J，CLEVERS H. Regulation and plasticity of toxic stress［J］. Nature，2019，566（7743）：249-253
intestinal stem cells during homeostasis and regeneration ［119］BITON M，HABER A L，ROGEL N，et al. T helper cell
［J］. Development，2016，143（20）：3639-3649 cytokines modulate intestinal stem cell renewal and differ⁃
［105］GREGORIEFF A，LIU Y，INANLOU M R，et al. Yap⁃ entiation［J］. Cell，2018，175（5）：1307-1320
+
dependent reprogramming of Lgr5 stem cells drives intes⁃ ［120］SONNENBERG G F，ARTIS D. Innate lymphoid cells in
tinal regeneration and cancer［J］. Nature，2015，526 the initiation，regulation and resolution of inflammation
（7575）：715-718 ［J］. Nat Med，2015，21（7）：698-708
［106］SERRA D，MAYR U，BONI A，et al. Self⁃organization and ［121］COSÍN⁃ROGER J，ORTIZ⁃MASIÁ D，CALATAYUD S，et
symmetry breaking in intestinal organoid development al. The activation of Wnt signaling by a STAT6 ⁃ depen⁃
［J］. Nature，2019，569（7754）：66-72 dent macrophage phenotype promotes mucosal repair in
［107］LI V S W. Yap in regeneration and symmetry breaking murine IBD［J］. Mucosal Immunol，2016，9（4）：986-998
［J］. Nat Cell Biol，2019，21（6）：665-667 ［122］JONES L G，VAIDA A，THOMPSON L M，et al. NF⁃κB2
［108］CALIBASI ⁃ KOCAL G，MASHINCHIAN O，BASBINAR signalling in enteroids modulates enterocyte responses to
Y ，et al. Nutritional control of intestinal stem cells in secreted factors from bone marrow⁃derived dendritic cells
homeostasis and tumorigenesis［J］. Trends Endocrinol ［J］. Cell Death Dis，2019，10（12）：896
Metab，2021，32（1）：20-35 ［123］HOU Q H，HUANG J X，AYANSOLA H，et al. Intestinal
［109］MADEO F，CARMONA⁃GUTIERREZ D，HOFER S J，et stem cells and immune cell relationships：potential thera⁃
al. Caloric restriction mimetics against age ⁃ associated peutic targets for inflammatory bowel diseases［J］. Front
disease：targets，mechanisms，and therapeutic potential Immunol，2021，11：623691
［J］. Cell Metab，2019，29（3）：592-610 ［124］SMITH K，MCCOY K D，MACPHERSON A J. Use of
［110］YILMAZ Ö H，KATAJISTO P，LAMMING D W，et al. axenic animals in studying the adaptation of mammals to
mTORC1 in the Paneth cell niche couples intestinal stem⁃ their commensal intestinal microbiota［J］. Semin Immu⁃
cell function to calorie intake［J］. Nature，2012，486 nol，2007，19（2）：59-69
（7404）：490-495 ［125］NOWACKI M R. Cell proliferation in colonic crypts of
［111］IGARASHI M ，GUARENTE L. mTORC1 and SIRT1 germ⁃free and conventional mice⁃preliminary report［J］.
cooperate to foster expansion of gut adult stem cells dur⁃ Folia Histochem Cytobiol，1993，31（2）：77-81
ing calorie restriction［J］. Cell，2016，166（2）：436-450 ［126］CIORBA M A，RIEHL T E，RAO M S，et al. Lactobacillus
［112］TEODORO J S，VARELA A T，ROLO A P，et al. High⁃fat probiotic protects intestinal epithelium from radiation in⁃
and obesogenic diets：current and future strategies to fight jury in a TLR ⁃ 2/cyclo ⁃oxygenase ⁃ 2 ⁃dependent manner
obesity and diabetes［J］. Genes Nutr，2014，9（4）：1-15 ［J］. Gut，2012，61（6）：829-838
［113］BEYAZ S，MANA M D，ROPER J，et al. High⁃fat diet ［127］LEE Y S，KIM T Y，KIM Y，et al. Microbiota⁃derived lac⁃
enhances stemness and tumorigenicity of intestinal pro⁃ tate accelerates intestinal stem ⁃ cell ⁃ mediated epithelial
genitors［J］. Nature，2016，531（7592）：53-58 development［J］. Cell Host Microbe，2018，24（6）：833-846
［114］DECLERCQ V，MCMURRAY D N，CHAPKIN R S. Obe⁃ ［128］HOU Q H，YE L L，LIU H F，et al. Lactobacillus accele⁃
sity promotes colonic stem cell expansion during cancer rates ISCs regeneration to protect the integrity of intesti⁃