Page 65 - 南京医科大学自然版

第44卷第12期 陈梦星，宗慧敏，张 洋. 糖基化基因构建的IgA肾病风险预测模型及免疫细胞浸润分析［J］.
2024年12月 南京医科大学学报（自然科学版），2024，44（12）：1671-1681 ·1679 ·

A
P=0.947 Control
0.5 IgAN
P=0.011
P=0.019
P=0.030
0.4
Fraction 0.3 P=0.137 P=0.017 P=0.255 P=0.571 P=0.438 P=0.007 P<0.001
P=0.038
P=0.422
P=0.800
P<0.001
P=0.107
P<0.001
P=0.006
P=0.444
0.2
P=0.649 P=0.215
0.1 P=0.257
0 +
（Tregs）
T cells follicular helper
NK cells activated
+ memory activated
Dendritic cells resting
Mast cells resting
Mast cells activated
Neutrophils
NK cells resting
B cells memory
Macrophages M0
Macrophages M2
B cells naive Plasma cells + memory resting T cells gamma delta Monocytes Macrophages M1 Dendritic cells activated Eosinophils
+ naive
T cells CD8
T cells CD4
T cells CD4 T cells regulatory
T cells CD4
B
***
P < 0.001
** P < 0.010
ST8SIA1 * ** * *** ** *** *** *** *** ** ** * **
*
P < 0.050
Correlation
PIGH ** ** * *** ** * *** * * ** *** ** * 0.50
0.25
0
-0.25
CHSY1 *** *** * *** *** *** *** *** ** *** *** *** -0.50
（Tregs）
+
T cells follicular helper
Macrophages M1
Macrophages M0
Mast cells resting
Mast cells activated
Dendritic cells activated
B cells memory Eosinophils Macrophages M2 Monocytes NK cells resting + memory resting + naive T cells gamma delta
Dendritic cells resting
B cells naive
NK cells activated
Plasma cells
+ memory activated
Neutrophils
T cells CD8
T cells CD4
T cells regulatory
T cells CD4
T cells CD4
A：Comparison of immunological microenvironments in IgAN and normal glomeruli samples. B：Differential study of the immunological micro⁃
environments caused by OFGs.
图5 免疫细胞浸润分析
Figure 5 Analysis of the immune cell infiltration

图6 IgAN的lncRNA⁃miRNA⁃mRNA网络
Figure 6 lncRNA⁃miRNA⁃mRNA network of IgAN