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南京医科大学学报(自然科学版)                                  第44卷第8期
               ·1146 ·                    Journal of Nanjing Medical University(Natural Sciences)   2024年8月


             ·流行病学研究·

              江苏省2004—2022年传染病突发公共卫生事件趋势分析



              陈紫颖 ,刘 鑫 ,刘文东 ,沈文琪 ,吴                  莹 ,时影影     2,3* ,胡建利  1,2,3,4*
                             1
                                              2,3
                                     2,3
                                                       2,3
                     1
               南京医科大学公共卫生学院,江苏 南京 211166;江苏省疾病预防控制中心急性传染病防制所,国家卫生健康委员会肠道病
              1                                       2                                  3
                               4
              原微生物重点实验室,江苏省卫生应急工程研究中心,江苏 南京 210009
             [摘    要] 目的:分析江苏省传染病突发公共卫生事件的流行特征,为防控工作开展提供科学依据。方法:采用joinpoint回归
              模型分析时间维度变化趋势,采用时空重排扫描探测时空聚集性。结果:2004—2022年累计报告传染病突发事件3 641起,累
              计报告发病 131 880 例,死亡 73 例,涉及 25 种法定传染病突发事件 1 868 起,其中甲类 76 起、乙类 391 起、丙类 1 401 起;涉及
              8 种其他传染病突发事件 1 773 起。Joinpoint 回归分析显示全省事件数呈增加趋势[平均年度变化百分比(average APC,
              AAPC)=16.28,P < 0.05)],甲类自2006年呈下降趋势(AAPC=-18.23,P < 0.05),乙类、丙类、其他均呈增加趋势(AAPC>0,P <
              0.05),苏南、苏中、苏北各区域事件数全局均呈增加趋势(AAPC>0,P < 0.05),苏南分为“快速增加—慢速增加—快速增加—减
              少”4个阶段,苏中事件数单调增加,苏北分为“增加—慢速减少—快速增加—减少”4个阶段。2006年、2015年、2018年为主要
              转折点。时空重排扫描共探测出8个时空聚集区,按发生顺序分别分布在苏中+苏南—苏北—苏南—苏南+苏北。结论:江苏
              省传染病突发事件总体呈现增加趋势,苏南和苏北聚集,苏中相对分散,重点地区需做好水痘、流行性感冒、手足口病等重点传
              染病的疫情监测和防控。
             [关键词] 传染病;突发公共卫生事件;joinpoint回归模型;时空重排扫描;趋势分析
             [中图分类号] R181.2                    [文献标志码] A                     [文章编号] 1007⁃4368(2024)08⁃1146⁃09
              doi:10.7655/NYDXBNSN231105


              Analysis of the trend of public health emergencies of infectious diseases in Jiangsu
              Province from 2004 to 2022

                         1        1            2,3           2,3       2,3           2,3*       1,2,3,4*
              CHEN Ziying ,LIU Xin ,LIU Wendong ,SHEN Wenqi ,WU Ying ,SHI Yingying     ,HU Jianli
              1 School of Public Health,Nanjing Medical University,Nanjing 211166;Acute Infectious Disease Prevention and
                                                                            2
                                                                                                       4
              Control Institute,National Health Commission(NHC)Key Laboratory of Enteric Pathogenic Microbiology,Jiangsu
                             3
              Provincial Health Emergency Engineering Research Center,Jiangsu Provincial Center for Disease Control and
              Prevention,Nanjing 210009,China


             [Abstract] Objective:To analyze the epidemic characteristics of public health emergencies of infectious disease in Jiangsu
              Province,and to provide scientific basis for prevention and control efforts. Methods:Joinpoint regression model was used to analyze the
              temporal trends,and space⁃time permutation scan was employed for spatiotemporal cluster detection and exploration. Results:From
              2004 to 2022,a total of 3 641 emergencies were reported,with 131 880 cases and 73 deaths. There were 1 868 emergencies involving
              25 notifiable infectious diseases,including 76 Class A,391 Class B,and 1 401 Class C diseases. Additionally,1 773 emergencies of 8
              other non⁃notifiable infectious diseases were involved. Joinpoint regression analysis revealed that the number of emergencies in Jiangsu
              Province showed an increasing trend[average APC(AAPC)=16.28,P < 0.05)]. Class A showed a declining trend since 2006
             (AAPC =-18.23,P < 0.05),while Class B,Class C,and others exhibited increasing trends(AAPC>0,P < 0.05). Emergencies in
              Southern of Jiangsu,Middle of jiangsu,and Northern of Jiangsu all showed increasing trend(AAPC>0,P < 0.05). In Southern of
              Jiangsu,the trend was characterized by 4 stages:rapid increase,slow increase,rapid increase,and decrease. In Middle of Jiangsu,
              Emergencies showed a monotonic increase. In Northern of Jiangsu,the trend was characterized by 4 stages:increase,slow decrease,

             [基金项目] 十四五江苏省科教能力提升工程—江苏省流行病学重点学科(ZDXK202250);2023年江苏省卫健委定向委托研
              究重点项目—“新冠高强度流行后再感染风险和影响因素研究”(DX202302)
              ∗
              通信作者(Corresponding author),E⁃mail:episyy@163.com;jshjl@jscdc.cn
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