Page 86 - 南京医科大学自然版

第45卷第1期
· 80 · 南 京 医 科 大 学 学 报 2025年1月

［57］FOURET G，TOLIKA E，LECOMTE J，et al. The mito⁃ ［69］DERBRÉ F，GOMEZ⁃CABRERA M C，NASCIMENTO A
chondrial ⁃ targeted antioxidant，MitoQ，increases liver L，et al. Age associated low mitochondrial biogenesis may
mitochondrial cardiolipin content in obesogenic diet⁃fed be explained by lack of response of PGC⁃1α to exercise
rats［J］. Biochim Biophys Acta，2015，1847（10）：1025-1035 training［J］. Age（Dordr），2012，34（3）：669-679
［58］LUMINI J A，MAGALHÃES J，OLIVEIRA P J，et al. Be⁃ ［70］ BAAR K. Involvement of PPAR gamma co⁃activator⁃1，
neficial effects of exercise on muscle mitochondrial func⁃ nuclear respiratory factors 1 and 2，and PPAR alpha in
tion in diabetes mellitus［J］. Sports Med，2008，38（9）： the adaptive response to endurance exercise［J］. Proc
735-750 Nutr Soc，2004，63（2）：269-273
［59］IEMITSU M，MIYAUCHI T，MAEDA S，et al. Aging⁃ ［71］ OSTOJIC O，O’LEARY M F N，SINGH K，et al. The
induced decrease in the PPAR ⁃ alpha level in hearts is effects of chronic muscle use and disuse on cardiolipin
improved by exercise training［J］. Am J Physiol Heart metabolism［J］. J Appl Physiol（1985），2013，114（4）：
Circ Physiol，2002，283（5）：H1750-H1760 444-452
［60］ MCMULLEN P D，BHATTACHARYA S，WOODS C G， ［72］WU F N，LI Z，CAI M X，et al. Aerobic exercise alleviates
et al. A map of the PPARα transcription regulatory network oxidative stress⁃induced apoptosis in kidneys of myocardial
for primary human hepatocytes［J］. Chem Biol Interact， infarction mice by inhibiting ALCAT1 and activating
2014，209：14-24 FNDC5/Irisin signaling pathway［J］. Free Radic Biol
［61］BRANDT J M，DJOUADI F，KELLY D P. Fatty acids acti⁃ Med，2020，158：171-180
vate transcription of the muscle carnitine palmitoyltrans⁃ ［73］REN W J，XU Z J，PAN S，et al. Irisin and ALCAT1 me⁃
feraseⅠgene in cardiac myocytes via the peroxisome pro⁃ diated aerobic exercise ⁃ alleviated oxidative stress and
liferator⁃activated receptor alpha［J］. J Biol Chem，1998， apoptosis in skeletal muscle of mice with myocardial
273（37）：23786-23792 infarction［J］. Free Radic Biol Med，2022，193（Pt 2）：
［62］JIANG Y J，LU B，XU F Y，et al. Stimulation of cardiac 526-537
cardiolipin biosynthesis by PPARalpha activation［J］. J ［74］ JÄGER S，HANDSCHIN C，ST⁃PIERRE J，et al. AMP⁃
Lipid Res，2004，45（2）：244-252 activated protein kinase（AMPK）action in skeletal muscle
［63］GIGUÈRE V. Transcriptional control of energy homeosta⁃ via direct phosphorylation of PGC⁃1alpha［J］. Proc Natl
sis by the estrogen ⁃ related receptors［J］. Endocr Rev， Acad Sci USA，2007，104（29）：12017-12022
2008，29（6）：677-696 ［75］CANTÓ C，GERHART ⁃ HINES Z，FEIGE J N，et al.
［64］DUFOUR C R，WILSON B J，HUSS J M，et al. Genome⁃ AMPK regulates energy expenditure by modulating NAD +
wide orchestration of cardiac functions by the orphan metabolism and SIRT1 activity［J］. Nature，2009，458：
nuclear receptors ERRalpha and gamma［J］. Cell Metab， 1056-1060
2007，5（5）：345-356 ［76］LI M T，HOU T Y，GAO T，et al. p53 cooperates with
［65］HUSS J M，TORRA I P，STAELS B，et al. Estrogen⁃related SIRT6 to regulate cardiolipin de novo biosynthesis［J］.
receptor alpha directs peroxisome proliferator ⁃ activated Cell Death Dis，2018，9（10）：941
receptor alpha signaling in the transcriptional control of ［77］SALEEM A，ADHIHETTY P J，HOOD D A. Role of p53
energy metabolism in cardiac and skeletal muscle［J］. in mitochondrial biogenesis and apoptosis in skeletal mus⁃
Mol Cell Biol，2004，24（20）：9079-9091 cle［J］. Physiol Genomics，2009，37（1）：58-66
［66］MITRA M S，SCHILLING J D，WANG X W，et al. Cardiac ［78］CAI Y，LIU H，SONG E F，et al. Deficiency of telomere⁃
lipin 1 expression is regulated by the peroxisome prolife⁃ associated repressor activator protein 1 precipitates cardiac
rator activated receptor γ coactivator 1α/estrogen related aging in mice via p53/PPARα signaling［J］. Theranostics，
receptor axis［J］. J Mol Cell Cardiol，2011，51（1）：120- 2021，11（10）：4710-4727
128 ［79］ FRITZEN A M，ANDERSEN S P，QADRI K A N，et al.
［67］LAI L，WANG M，MARTIN O J，et al. A role for peroxi⁃ Effect of aerobic exercise training and deconditioning on
someproliferator⁃activatedreceptor γcoactivator1（PGC⁃1） oxidative capacity and muscle mitochondrial enzyme ma⁃
in the regulation of cardiac mitochondrial phospholipid chinery in young and elderly individuals［J］. J Clin Med，
biosynthesis［J］. J Biol Chem，2014，289（4）：2250-2259 2020，9（10）：3113
［68］LEMOINE C M R，LOUGHEED S C，MOYES C D. Modu⁃ ［80］KONOPKA A R，SUER M K，WOLFF C A，et al. Markers
lar evolution of PGC ⁃ 1alpha in vertebrates［J］. J Mol ofhumanskeletalmusclemitochondrialbiogenesisandqual⁃
Evol，2010，70（5）：492-505 ity control：effects of age and aerobic exercise training［J］.