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第45卷第1期 张宸恺，王壮志，李方晖. 运动通过调节心磷脂合成及重塑干预衰老相关疾病［J］.
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Ups2p antagonistically regulate cardiolipin metabolism adipose tissue metabolomics and inflammation，cardiolipin
in mitochondria［J］. J Cell Biol，2009，185（6）：1029- metabolism，and ferroptosis markers in female aged rat
1045 model［J］. Biochem Biophys Res Commun，2023，671：
［34］ROMANELLO V. The interplay between mitochondrial 292-300
morphology and myomitokines in aging sarcopenia［J］. Int ［46］COLE L K，MEJIA E M，SPARAGNA G C，et al. Cardio⁃
J Mol Sci，2020，22（1）：91 lipin deficiency elevates susceptibility to a lipotoxic
［35］LEENDERS M，VERDIJK L B，VAN DER HOEVEN L， hypertrophic cardiomyopathy［J］. J Mol Cell Cardiol，
et al. Patients with type 2 diabetes show a greater decline 2020，144：24-34
in muscle mass，muscle strength，and functional capacity ［47］KAUTZKY⁃WILLER A，HARREITER J，PACINI G. Sex
with aging［J］. J Am Med Dir Assoc，2013，14（8）：585- and gender differences in risk，pathophysiology and com⁃
592 plications of type 2 diabetes mellitus［J］. Endocr Rev，
［36］ SEMBA R D，MOADDEL R，ZHANG P B，et al. Tetra⁃ 2016，37（3）：278-316
linoleoyl cardiolipin depletion plays a major role in the ［48］HSU P，SHI Y G. Regulation of autophagy by mitochondrial
pathogenesis of sarcopenia［J］. Med Hypotheses，2019， phospholipids in health and diseases［J］. Biochim Biophys
127：142-149 Acta Mol Cell Biol Lipids，2017，1862（1）：114-129
［37］MONTEIRO⁃CARDOSO V F，OLIVEIRA M M，MELO T， ［49］WANG D，JI D C，YU C Y，et al. Research progress on
et al. Cardiolipin profile changes are associated to the early the mitochondrial mechanism of age⁃related non⁃alcoholic
synaptic mitochondrial dysfunction in Alzheimer’s dis⁃ fatty liver［J］. World J Gastroenterol，2023，29（13）：
ease［J］. J Alzheimers Dis，2015，43（4）：1375-1392 1982-1993
［38］ CHICCO A J ，SPARAGNA G C. Role of cardiolipin ［50］SHIMOMURA Y，WADA K，FUKUYAMA K，et al. The
alterations in mitochondrial dysfunction and disease［J］. asymmetric trimeric architecture of［2Fe⁃2S］IscU：impli⁃
Am J Physiol Cell Physiol，2007，292（1）：C33-C44 cations for its scaffolding during iron⁃sulfur cluster bio⁃
［39］DEHGHANI Z，MERATAN A A，SABOURY A A，et al. synthesis［J］. J Mol Biol，2008，383（1）：133-143
α ⁃ synuclein fibrillation products trigger the release of ［51］PATIL V A，FOX J L，GOHIL V M，et al. Loss of cardio⁃
hexokinase I from mitochondria：protection by curcumin， lipin leads to perturbation of mitochondrial and cellular
and possible role in pathogenesis of Parkinson’s disease［J］. iron homeostasis［J］. J Biol Chem，2013，288（3）：1696-
Biochim Biophys Acta Biomembr，2020，1862（6）：183251 1705
［40］ SMITH W W，JIANG H B，PEI Z，et al. Endoplasmic ［52］STOCKWELL B R，ANGELI J P F，BAYIR H，et al. Fer⁃
reticulum stress and mitochondrial cell death pathways roptosis：a regulated cell death nexus linking metabolism，
mediateA53Tmutantalpha⁃synuclein⁃inducedtoxicity［J］. redox biology，and disease［J］. Cell，2017，171（2）：273-
Hum Mol Genet，2005，14（24）：3801-3811 285
［41］BAYIR H，KAPRALOV A A，JIANG J，et al. Peroxidase ［53］PATIL V A，LI Y R，JI J J，et al. Loss of the mitochondrial
mechanism of lipid⁃dependent cross⁃linking of synuclein lipid cardiolipin leads to decreased glutathione synthe⁃
with cytochrome C：protection against apoptosis versus sis［J］. Biochim Biophys Acta Mol Cell Biol Lipids，2020，
delayed oxidative stress in Parkinson disease［J］. J Biol 1865（2）：158542
Chem，2009，284（23）：15951-15969 ［54］SHIMOJI M，IMAIZUMI N，ANIYA Y. Modulation of
［42］ FORMAN M S，SCHMIDT M L，KASTURI S，et al. Tau membrane⁃bound glutathione transferase activity by phos⁃
and alpha ⁃ synuclein pathology in amygdala of Parkin⁃ pholipids including cardiolipin［J］. Biol Pharm Bull，
sonism ⁃ dementia complex patients of Guam［J］. Am J 2011，34（2）：209-213
Pathol，2002，160（5）：1725-1731 ［55］BIRK A V，LIU S Y，SOONG Y，et al. The mitochondrial⁃
［43］SONG C J，ZHANG J，QI S S，et al. Cardiolipin remode⁃ targeted compound SS⁃31 re⁃energizes ischemic mitochon⁃
ling by ALCAT1 links mitochondrial dysfunction to Par⁃ dria by interacting with cardiolipin［J］. J Am Soc Nephrol，
kinson’s diseases［J］. Aging Cell，2019，18（3）：e12941 2013，24（8）：1250-1261
［44］HANNUKAINEN J C，KALLIOKOSKI K K，BORRA R J， ［56］NG L F，GRUBER J，CHEAH I K，et al. The mitochondria⁃
et al. Higher free fatty acid uptake in visceral than in targeted antioxidant MitoQ extends lifespan and improves
abdominal subcutaneous fat tissue in men［J］. Obesity， healthspan of a transgenic Caenorhabditis elegans model
2010，18（2）：261-265 of Alzheimer disease［J］. Free Radic Biol Med，2014，71：
［45］WANG Z Z，LI F H，NI P S，et al. Age⁃related changes in 390-401