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[30]DICHTL S,LINDENTHAL L,ZEITLER L,et al. Lactate rence[J]. FEBS J,2021,288(21):6286-6303
and IL6 define separable paths of inflammatory metabolic [42]WU Y,SONG Y,WANG R,et al. Molecular mechanisms
adaptation[J]. Sci Adv,2021,7(26):eabg3505 of tumor resistance to radiotherapy[J]. Mol Cancer,2023,
[31]JIN M,CAO W,CHEN B,et al. Tumor⁃derived lactate cre⁃ 22(1):96
ates a favorable niche for tumor via supplying energy [43]AMRUTKAR M,BERG K,BALTO A,et al. Pancreatic
source for tumor and modulating the tumor microenviron⁃ stellate cell⁃induced gemcitabine resistance in pancreatic
ment[J]. Front Cell Dev Biol,2022,10:808859 cancer is associated with LDHA⁃ and MCT4⁃mediated en⁃
[32]ABAZA M,LUQMANI Y A. The influence of pH and hy⁃ hanced glycolysis[J]. Cancer Cell Int,2023,23(1):9
poxia on tumor metastasis[J]. Expert Rev Anticancer [44]YANG X,LU Y,HANG J,et al. Lactate⁃modulated immu⁃
Ther,2013,13(10):1229-1242 nosuppression of myeloid ⁃ derived suppressor cells con⁃
[33]COLEGIO O R,CHU N,SZABO A L,et al. Functional po⁃ tributes to the radioresistance of pancreatic cancer[J].
larization of tumour⁃associated macrophages by tumour⁃ Cancer Immunol Res,2020,8(11):1440-1451
derived lactic acid[J]. Nature,2014,513(7519):559-563 [45]GAN J,WANG W,YANG Z,et al. Prognostic value of pre⁃
[34]WANG Z,PENG W,ZHANG P,et al. Lactate in the tu⁃ treatment serum lactate dehydrogenase level in pancreatic
mour microenvironment:from immune modulation to ther⁃ cancer patients:a meta⁃analysis of 18 observational stud⁃
apy[J]. EBioMedicine,2021,73:103627 ies[J]. Medicine(Baltimore),2018,97(46):e13151
[35]JIANG M,WANG Y,ZHAO X,et al. From metabolic by⁃ [46]YU S,XU L,QI Q,et al. Serum lactate dehydrogenase pre⁃
product to immune modulator:the role of lactate in tumor dicts prognosis and correlates with systemic inflammatory
immune escape[J]. Front Immunol,2024,15:1492050 response in patients with advanced pancreatic cancer after
[36]KANEMARU H,MIZUKAMI Y,KANEKO A,et al. A gemcitabine⁃based chemotherapy[J]. Sci Rep,2017,7:
mechanism of cooling hot tumors:lactate attenuates in⁃ 45194
flammation in dendritic cells[J]. iScience,2021,24(9): [47]KERSLAKE R,PANFILOV S,MUSTAFA N,et al. Elevat⁃
103067 ed circulating lactate levels and widespread expression of
[37]HE Z,ZHANG S. Tumor ⁃ associated macrophages and its cognate receptor,hydroxycarboxylic acid receptor 1
their functional transformation in the hypoxic tumor micro⁃ (HCAR1),in ovarian cancer[J]. J Clin Med,2022,12
environment[J]. Front Immunol,2021,12:741305 (1):217
[38]SAFFI G T,TO L,KLEINE N,et al. INPP4B promotes [48]WANG X,WANG C,ZHANG H. Improvement of diagnos⁃
PDAC aggressiveness via PIKfyve and TRPML⁃1⁃mediat⁃ tic accuracy for pancreatic cancer with serum lactate de⁃
ed lysosomal exocytosis[J]. J Cell Biol,2024,223(11): hydrogenase[J]. Cancer Manag Res,2021,13:4879-
e202401012 4886
[39]GU X,YANG J,LAI R,et al. Impact of lactate on immune [49]BABL N,DECKING S,VOLL F,et al. MCT4 blockade in⁃
cell function in the tumor microenvironment:mechanisms creases the efficacy of immune checkpoint blockade[J]. J
and therapeutic perspectives[J]. Front Immunol,2025, Immunother Cancer,2023,11(10):e007349
16:1563303 [50]HALFORD S,VEAL G J,WEDGE S R,et al. A phase Ⅰ
[40]BOGDANOV A,BOGDANOV A,CHUBENKO V,et al. dose⁃escalation study of AZD3965,an oral monocarboxyl⁃
Tumor acidity:from hallmark of cancer to target of treat⁃ ate transporter 1 inhibitor,in patients with advanced can⁃
ment[J]. Front Oncol,2022,12:979154 cer[J]. Clin Cancer Res,2023,29(8):1429-1439
[41]DAMEN M P F,VAN RHEENEN J,SCHEELE C L G J. [收稿日期] 2025-05-19
Targeting dormant tumor cells to prevent cancer recur⁃ (本文编辑:唐 震)

