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第45卷第12期 印芷睿,崔 畅. 扩张型心肌病性别差异的机制与精准治疗研究进展[J].
2025年12月 南京医科大学学报(自然科学版),2025,45(12):1845-1852 ·1851 ·
[参考文献] son of X⁃chromosome inactivation in Duchenne muscle/
myocardium⁃manifesting carriers,non⁃manifesting carriers
[1] TSAO C W,ADAY A W,ALMARZOOQ Z I,et al. Heart
and related daughters[J]. Clin Genet,2013,84(3):265-
disease and stroke statistics⁃ 2022 update:a report from
270
the American heart association[J]. Circulation,2022,145
[15] TROGISCH F A,ABOUISSA A,KELES M,et al. Endo⁃
(8):e153-e639
thelial cells drive organ fibrosis in mice by inducing
[2] SCHULTHEISS H P,FAIRWEATHER D,CAFORIO A L
expression of the transcription factor SOX9[J]. Sci
P,et al. Dilated cardiomyopathy[J]. Nat Rev Dis Primers,
Transl Med,2024,16(736):eabq4581
2019,5:32
[16]LIU C F,NI Y,THACHIL V,et al. Differential expression
[3] ARGIRÒ A,HO C,DAY S M,et al. Sex⁃related differences
of members of SOX family of transcription factors in
in genetic cardiomyopathies[J]. J Am Heart Assoc,2022,
failing human hearts[J]. Transl Res,2022,242:66-78
11(9):e024947
[17]LIU Y F,JIANG B,CAO Y D,et al. High expression levels
[4] CODD M B,SUGRUE D D,GERSH B J,et al. Epidemiology
and localization of Sox5 in dilated cardiomyopathy[J].
of idiopathic dilated and hypertrophic cardiomyopathy:a
Mol Med Rep,2020,22(2):948-956
population ⁃ based study in Olmsted County,Minnesota,
[18] VISSING C R,RASMUSSEN T B,DYBRO A M,et al.
1975-1984[J]. Circulation,1989,80(3):564-572
Dilated cardiomyopathy caused by truncating titin variants:
[5] BERGAN N,PRACHEE I,CURRAN L,et al. Systematic
long ⁃ term outcomes,arrhythmias,response to treatment
review,meta⁃analysis,and population study to determine
and sex differences[J]. J Med Genet,2021,58(12):
the biologic sex ratio in dilated cardiomyopathy[J]. Circu⁃
832-841
lation,2025,151(7):442-459
[19]HEY T M,RASMUSSEN T B,MADSEN T,et al. Pathogenic
[6] LONG C Y,LIU X,XIONG Q M,et al. Sex differences in
RBM20 ⁃ variants are associated with a severe disease
dilated cardiomyopathy prognosis[J]. Int Heart J,2022,
expression in male patients with dilated cardiomyopathy[J].
63(1):36-42
Circ Heart Fail,2019,12(3):e005700
[7] MCNAMARA D M,STARLING R C,COOPER L T,et al.
[20]VAN RIJSINGEN I A W,NANNENBERG E A,ARBUS⁃
Clinical and demographic predictors of outcomes in recent
TINI E,et al. Gender⁃specific differences in major cardiac
onset dilated cardiomyopathy:results of the IMAC(Inter⁃
events and mortality in lamin A/C mutation carriers[J].
vention in Myocarditis and Acute Cardiomyopathy)⁃ 2
Eur J Heart Fail,2013,15(4):376-384
study[J]. J Am Coll Cardiol,2011,58(11):1112-1118
[8] YOKOUCHI⁃KONISHI T,KAMIYA C A,SHIONOIRI T, [21]WOLF C M,WANG L B,ALCALAI R,et al. Lamin A/C
haploinsufficiency causes dilated cardiomyopathy and
et al. Pregnancy outcomes in women with dilated cardio⁃
apoptosis⁃triggered cardiac conduction system disease[J].
myopathy:peripartum cardiovascular events predict post
J Mol Cell Cardiol,2008,44(2):293-303
delivery prognosis[J]. J Cardiol,2021,77(3):217-223
[22] PEI H,WANG W,ZHAO D,et al. G protein⁃coupled
[9] BANGI E F,MAIKAWA N,KAUR A,et al. Pregnancy in
women with dilated cardiomyopathy[J]. Future Cardiol, estrogen receptor 1 inhibits angiotensin II⁃induced cardio⁃
2022,18(8):661-667 myocyte hypertrophy via the regulation of PI3K⁃Akt⁃mTOR
signalling and autophagy[J]. Int J Biol Sci,2019,15(1):
[10]HERSHBERGER R E,COWAN J,JORDAN E,et al. The
complex and diverse genetic architecture of dilated cardio⁃ 81-92
myopathy[J]. Circ Res,2021,128(10):1514-1532 [23]WANG M J,WANG Y,WEIL B,et al. Estrogen receptor
[11] KAYVANPOUR E,SEDAGHAT ⁃ HAMEDANI F,AMR beta mediates increased activation of PI3K/Akt signaling
A,et al. Genotype ⁃ phenotype associations in dilated and improved myocardial function in female hearts follow⁃
cardiomyopathy:meta⁃analysis on more than 8000 indi⁃ ing acute ischemia[J]. Am J Physiol Regul Integr Comp
viduals[J]. Clin Res Cardiol,2017,106(2):127-139 Physiol,2009,296(4):R972-R978
[12]KELLERMAYER D,SMITH J E 3rd,GRANZIER H. Titin [24] YU H P,HSIEH Y C,SUZUKI T,et al. The PI3K/Akt
mutations and muscle disease[J]. Pflugers Arch,2019, pathway mediates the nongenomic cardioprotective effects
471(5):673-682 of estrogen following trauma⁃hemorrhage[J]. Ann Surg,
[13]FLORCZYK⁃SOLUCH U,POLAK K,DULAK J. The mul⁃ 2007,245(6):971-977
tifaceted view of heart problem in Duchenne muscular [25]IORGA A,CUNNINGHAM C M,MOAZENI S,et al. The
dystrophy[J]. Cell Mol Life Sci,2021,78(14):5447-5468 protective role of estrogen and estrogen receptors in
[14] VIGGIANO E,PICILLO E,CIRILLO A,et al. Compari⁃ cardiovascular disease and the controversial use of estro⁃

