Page 61 - 南京医科大学自然版

第45卷第5期 孙书凝，龚予希，杨野梵，等. CYB5R2在弥漫大B细胞淋巴瘤中的表达及其临床意义［J］.
2025年5月 南京医科大学学报（自然科学版），2025，45（5）：644-651 ·647 ·

HE IHC HE IHC

DLBCL

A B C D

FL

E F G H

MALT

I J K L

MCL

M N O P

SLL/CLL

Q P S T
A：HE staining of DLBCL tissue. B：Corresponding area showing strong positive expression（high expression group）of CYB5R2 by immunohisto⁃
chemical（IHC）staining. C：HE staining of another DLBCL tissue. D：Corresponding area showing weak positive expression（zero or low expression
group）of CYB5R2 by IHC staining. E：HE staining of FL tissue. F：Corresponding area showing strong positive expression（high expression group）of
CYB5R2 by IHC staining. G：HE staining of another FL tissue. H：Corresponding area showing weak positive expression（zero or low expression group）
of CYB5R2 by IHC staining. I：HE staining of MALT tissue. J：Corresponding area showing strong positive expression（high expression group）of
CYB5R2 by IHE staining. K：HE staining of another MALT tissue. L：Corresponding area showing weak positive expression（zero or low expression
group）of CYB5R2 by IHC staining. M：HE staining of MCL tissue. N：Corresponding area showing strong positive expression（high expression group）of
CYB5R2 by IHC staining. O：HE staining of another MCL tissue. P：Corresponding area showing weak positive expression（zero or low expression group）
of CYB5R2 by IHC staining. Q：HE siaining of SLL/CLL tissue. R：Corresponding area showing strong positive expression（high expression group）of
CYB5R2 by IHC staining. S：HE staining of another SLL/CLL tissue. T：Corresponding area showing weak positive expression（zero or low expression
group）of CYB5R2 by IHC staining. Scale bar=25μm.
图2 CYB5R2在DLBCL和小B细胞淋巴瘤中的性表达
Figture 2 Expression of CYB5R2 in DLBCL and small B⁃cell lymphoma tissues

37.3%），BCL⁃6 阳性 53 例（53/59，89.8%），BCL⁃2 阳 （47/59，79.7%），CD5 阳性 5 例（5/59，8.5%），CD30

性 46 例（46/59，78.0%），MUM⁃1 阳性有 47 例（47/ 阳性 5 例（5/59，8.5%），c⁃Myc 阳性（40%以上）16 例
59，79.7%），Ki⁃67 高增殖表达（75%以上）47 例 （16/59，27.1%）。