Page 41 - 南京医科大学自然版

第45卷第7期 陶子凡，刘一纬，吴晓峰，等. Wnt/PCP通路和细胞外基质力学信号共同调控CNN2促进肝癌
2025年7月 细胞群体性迁移［J］. 南京医科大学学报（自然科学版），2025，45（7）：936-944 ·939 ·

A B 250 Consensus dataset
RNA expression （nTPM） 150
200
100
RNA expression Protein expression 50
Brain 0
Cerebral cortex Basal ganglia Hypothalamus Choroid plexus Thyroid gland Adrenal gland pituitary gland Salivary gland Small intestine Seminal vesicle Fallopian tube Endometrium Heart muscle Smooth muscle Skeletal muscle Adipose tissue Lymph node Bone marrow
Eye Cerebellum Midbrain Amygdala Spinal cord Retina Lung Esophagus Tongue Stomach Duodenum Colon Rectum Liver Gallbladder Pancreas Kidney Testis Epididymis Prostate Vagina Ovary Cervix Placenta Breast Skin Appendix Spleen Tonsil Thymus
Endocrine Parathyroid gland Urinary bladder
tissues Hippocampal formation
Respiratory
system
Proximal
digestive tract
250
Gastrointestinal HPA dataset
tract 200
Liver & 150
gallbladder RNA expression （nTPM） 100
Pancreas 50
Kidney & 0
Cerebral cortex Choroid plexus Parathyroid gland Urinary bladder Seminal vesicle Smooth muscle Skeletal muscle
urinary bladder Lung Tongue Stomach Colon Rectum Liver Pancreas Kidney Testis Prostate Ovary Cervix Placenta Breast Skin Spleen Tonsil Thymus
Male tissues Thyroid gland Adrenal gland Salivary gland Esophagus Duodenum Small intestine Gallbladder Epididymis Fallopian tube Endometrium Heart muscle Adipose tissue Appendix Lymph node Bone marrow
Female tissues
Muscle tissues
GTEx dataset
Connective & 200
soft tissue 150
Skin RNA expression （nTPM） 100
Bone marrow & 50
lymphoid
tissues 0 Lung Liver Ovary Skin
Skeletal muscle
Midbrain
Hypothalamus
Cerebellum
Fallopian tube
Cerebral cortex Basal ganglia Hippocampal formation Thyroid gland pituitary gland Salivary gland Small intestine Colon Pancreas Kidney Testis Prostate Vagina Endometrium Cervix Heart muscle Adipose tissue Spleen
Spinal cord
Amygdala
Retina
Breast
Urinary bladder
Stomach
Adrenal gland
Esophagus
C
700
600
RNA expression （nTPM） 400
500
300
200
100
0
5637
U⁃87MG
BxPC⁃3 Huh⁃28 786⁃O MDA⁃MB⁃435 RT⁃4 T98G Ramos A⁃431 CACO⁃2 HT⁃29 A2780 CAL⁃27 DU145 THP⁃1 HaCaT SiHa TE⁃1 HeLa HL⁃60 PANC⁃1 FaDu U⁃251MG BEWO ACHN U2OS RPMI⁃8226 RL95⁃2 SNU⁃308 Rh30 Calu⁃3 A⁃549 SK⁃N⁃SH MG⁃63 ML⁃1 PC⁃3 MCF⁃7 HEK293 LP⁃1
SK⁃OV⁃3
HCC1576
SK⁃BR⁃3
RD
SuSa
OE33
AGS
SCaBER
Hep 3B2.1⁃7
Raji
SH⁃SY5Y
A⁃204
HT⁃1080
Hep⁃G2
D
500
RNA expression （nTPM） 300
400
200
100
0
SNU⁃423 Huh⁃7 Hep 3B2.1⁃7 JHH⁃2 SNU⁃886 SNU⁃398 SNU⁃475 HLF SNU⁃761 SNU⁃449 SNU⁃387 Huh⁃1 PLC/PRF/5 Hep⁃G2 SNU⁃182 JHH⁃5 SK⁃HEP⁃1 JHH⁃6 Huh⁃6 JHH⁃4 Li⁃7 JHH⁃7 SNU⁃878 JHH⁃1
A，B：CNN2 RNA and protein expression in human tissues from the HPA database. nTPM（normalized transcripts per million）. C：The expression
of CNN2 in different cell lines. D：The expression of CNN2 in liver cancer cell lines.
图1 CNN2在肝癌组织中高表达
Figure 1 High expression of CNN2 in liver cancer tissues