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利益冲突声明: [8] NOPORA A,WEIDLE U H. CircRNAs as new therapeu⁃
所有作者声明无利益冲突。 tic entities and tools for target identification in acute my⁃
Conflict of Interests: eloid leukemia[J]. Cancer Genomics Proteomics,2024,
The authors declare no competing interests. 21(2):118-136
作者贡献声明: [9] 杨 奕,欧阳松应,吴军军. 环状RNA在肿瘤诊疗中的
张鸽负责细胞实验以及论文撰写;陈昕负责RNA测序、 应用[J]. 中国生物化学与分子生物学报,2025,41(3):
验证实验和论文修订;顾婧瑶负责生信分析和论文修订;王 344-352
朝霞负责实验设计、论文修订及定稿和资金支持。 YANG Y,OUYANG S Y,WU J J. Application of crcular
Author’s Contribution: RNA in diagnosis and treatment of tumor[J]. Chinese
ZHANG Ge was responsible for cell experiments and paper Journal of Biochemistry and Molecular Biology,2025,41
writing;CHEN Xin was responsible for conducting RNA se⁃ (3):344-352
quencing,performing verification experiments,and revising the [10]ZHAO X,ZHONG Y X,WANG X D,et al. Advances in
manuscript;GU Jingyao was responsible for bioinformatics anal⁃ circular RNA and its applications[J]. Int J Med Sci,
ysis and thesis revision;WANG Zhaoxia was responsible for the 2022,19(6):975-985
experimental design,revision and finalization of the paper,as [11]LI H C,XU W,XIA Z H,et al. Hsa_circ_0000199 facili⁃
well as financial support. tates chemo⁃tolerance of triple⁃negative breast cancer by
interfering with miR ⁃ 206/613 ⁃ led PI3K/Akt/mTOR
[参考文献]
signaling[J]. Aging(Albany NY),2021,13(3):4522-
[1] 郑荣寿,陈 茹,韩冰峰,等. 2022 年中国恶性肿瘤流
4551
行情况分析[J]. 中华肿瘤杂志,2024,46(3):221-231
[12]TANG Y F,LIU Z H,ZHANG L Y,et al. circ_PPAP⁃
ZHENG R S,CHEN R,HAN B F,et al. Cancer incidence
DC1A promotes osimertinib resistance by sponging the
and mortality in China,2022[J]. Chinese Journal of On⁃
miR⁃30a⁃3p/ IGF1R pathway in non⁃small cell lung can⁃
cology,2024,46(3):221-231
cer(NSCLC)[J]. Mol Cancer,2024,23(1):91
[2] TESTA U,CASTELLI G,PELOSI E. Lung cancers:molec⁃ [13]ZHANG J,LUO Z,ZHENG Y,et al. CircRNA as an Achil⁃
ular characterization,clonal heterogeneity and evolution, les heel of cancer:characterization,biomarker and thera⁃
and cancer stem cells[J]. Cancers(Basel),2018,10(8): peutic modalities[J]. J Transl Med,2024,22(1):752
248
[14]CHEN X,GU J Y,HUANG J L,et al. Characterization of
[3] FUKUHARA T,IMAI K,NAKAGAWA T,et al. A pro⁃
circRNAs in established osimertinib⁃resistant non⁃small
spective cohort study assessing the relationship between
cell lung cancer cell lines[J]. Int J Mol Med,2023,52
plasma levels of osimertinib and treatment efficacy and (5):102
safety[J]. Biomedicines,2023,11(9):2501 [15]CHEN J B,YANG H C,TEO A S M,et al. Genomic land⁃
[4] LAMB Y N. Osimertinib:a review in previously untreated, scape of lung adenocarcinoma in East Asians[J]. Nat
EGFR mutation ⁃ positive,advanced NSCLC[J]. Target Genet,2020,52(2):177-186
Oncol,2021,16(5):687-695 [16]FU K,XIE F C,WANG F,et al. Therapeutic strategies for
[5] IBUSUKI R,IWAMA E,SHIMAUCHI A,et al. TP53 gain EGFR⁃mutated non⁃small cell lung cancer patients with
⁃of⁃function mutations promote osimertinib resistance via osimertinib resistance[J]. J Hematol Oncol,2022,15(1):
TNF⁃α⁃NF⁃κB signaling in EGFR⁃mutated lung cancer 173
[J]. NPJ Precis Oncol,2024,8(1):60 [17]ZENG Y,YU D L,TIAN W T,et al. Resistance mecha⁃
[6] BRONTE G,BELLONI A,CALABRÒ L,et al. The great nisms to osimertinib and emerging therapeutic strategies
need to overcome osimertinib resistance in advanced non⁃ in nonsmall cell lung cancer[J]. Curr Opin Oncol,2022,
small cell lung cancer:from combination strategies to 34(1):54-65
fourth⁃generation tyrosine kinase inhibitors[J]. Front On⁃ [18]杨贤苗,钱粉红. 环状 RNA 与支气管哮喘相关性研
col,2023,13:1308460 究[J]. 南京医科大学学报(自然科学版),2022,42(4):
[7] FERRO A,MARINATO G M,MULARGIU C,et al. The 595-599
study of primary and acquired resistance to first ⁃ line YANG X M,QIAN F H. Correlation between circRNA
osimertinib to improve the outcome of EGFR⁃mutated ad⁃ and bronchial asthma[J]. Journal of Nanjing Medical Uni⁃
vanced non⁃small cell lung cancer patients:the challenge versity(Natural Science),2022,42(4):595-599
is open for new therapeutic strategies[J]. Crit Rev Oncol [19]XU T W,WANG M W,JIANG L H,et al. CircRNAs in an⁃
Hematol,2024,196:104295 ticancer drug resistance:recent advances and future po⁃

